BPS2026 Program Book

475-Pos Board B287 SELECTIVE ELIMINATION OF NA+ BINDING IN KLEBSIELLA PNEUMONIAE MELB. Souptik Ghosh , Hariharan Parameswaran, Lan Guan 476-Pos Board B288 ION TRANSLOCATION MECHANISM OF NA + -PUMPING NADH-QUINONE OXIDOREDUCTASE FROM MOLECULAR DYNAMICS SIMULATIONS. Takehito Seki , Jun Ohnuki, Kei-ichi Okazaki 477-Pos Board B289 EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION OF THE MECHA NISM OF CHLORIDE DEPENDENCE IN SYSTEM X C − . Gabriel D. Seaver , Leah A. Chase, Brent P. Krueger 478-Pos Board B290 MODIFICATION OF BETA-BARREL NANOPORES AND RECONSTITUTION VIA MEMBRANE FUSION BETWEEN NANODISCS AND LIPID VESI CLES. Toshiyuki Tosaka , Koki Kamiya 479-Pos Board B291 BREAKING THE ICE ON MNEP: TOWARD THE STRUCTURAL AND FUNC TIONAL CHARACTERIZATION OF A BACTERIAL MANGANESE TRANS PORTER. Paul-Pierre Boutet , Keiki V. Miller, Oliver Nicholson, Luisa Morgan, Shivani Ahuja 480-Pos Board B292 USING DIMENSIONALITY REDUCTION TO FIND CAUSES OF CONFORMA TIONAL TRANSITIONS IN TRANSPORTERS. Joshua Raphael Uy , Oliver Beckstein 481-Pos Board B293 PARADOXICAL SERCA DYSREGULATION PROMOTES ATRIAL FIBRILLATION IN A DIET-INDUCED OBESITY MODEL. Carlos Cruz Cortes 482-Pos Board B294 FLUORESCENCE LIFETIME SPECTROSCOPY REVEALS MICROPEPTIDE REGULATION OF SERCA HOMODIMERS. Hannah E. Kersemeier , Caroline Erpelding, Alexis Mazzenga, Ellen Cho, Jacob Cunningham, Jordan Beach, Seth L. Robia 483-Pos Board B295 PHOSPHOLAMBAN AND SARCOLIPIN SHARE SIMILARTRANSMEM BRANE ZIPPER MOTIFS THAT CONTROL SELF-ASSOCIATION AFFINITY AND HOMO-OLIGOMER STOICHIOMETRY. Bengt Svensson , Nicholas R. DesLauriers, John E. Rubin, Joseph M. Autry, Razvan L. Cornea, Robyn T. Rebbeck, David D. Thomas 484-Pos Board B296 FUNCTIONAL EVALUATION OF ATP1A1 MISSENSE VARIANTS: GLY903ARG, SER207PHE, GLY877SER, GLY864ARG. Navya Kavuri , Nicolas G. Colmano, Pablo Artigas 485-Pos Board B297 MEASURING CONFORMATIONAL CHANGES OF ABCB10 DURING THE BASAL AND SUBSTRATE-STIMULATED ATPASE CYCLE USING LRET. Alex L. Hernandez , Maria E. Zoghbi 486-Pos Board B298 A HINGE-GUIDED SINGLE-DOMAIN SIGNAL IN AN ABC EXPORT ER. Zohreh Rostami , Po-Chao Wen, Victor Hugo Perez Carrillo, Ute A. Hellmich, Emad Tajkhorshid 487-Pos Board B299 FUNCTIONAL IMPLICATIONS OF THE CONFORMATIONAL LANDSCAPE OF A MULTIDRUG TRANSPORTER REVEALED BY STRUCTURES OF ZEBRAFISH ABCB4. Jingyu Zhan , Chao-Ming Hsieh, Lothar Esser, Zabrina C. Lang, Abraham J. Morton, Robert Robey, Fei Zhou, Suresh V. Ambudkar, Rick K. Huang, Michael M. Gottesman, Di Xia

488-Pos Board B300 COMPUTATIONAL INVESTIGATION REVEALS THE AUTOINHIBITORY MECHANISM OF THE HUMAN SERCA2B C-TERMINAL EXTENSION. Rulong Ma , James M. Briggs 489-Pos Board B301 Travel Award Winner TMEM65 FUNCTIONS AS THE MITOCHONDRIAL NA + /CA 2+ EXCHANG ER. Po-Hsuan Lai , Ming-Feng Tsai 490-Pos Board B302 TMEM65 RECONSTITUTES MITOCHONDRIAL NA + /CA 2+ EXCHANGE. Jim L. Zhang , Yu-Chen Chang, Liang Feng, Ming-Feng Tsai 491-Pos Board B303 INVESTIGATING THE STRUCTURAL DYNAMICS OF SUBSTRATE AND ION BINDING IN NACT. Noah Trebesch , Emad Tajkhorshid 492-Pos Board B304 EXPLORING ADEC VARIANT DYNAMICS TO UNDERSTAND EFFLUX-ME DIATED RESISTANCE IN ACINETOBACTER BAUMANNII . Isik Kantarcioglu Mazmanoglu , Ata Göktug Çim, Ali Rana Atilgan, Canan Atilgan 493-Pos Board B305 NOVEL LIPID RECOGNITION AND ACTIVATION MECHANISM OF A P4-ATPASE ELUCIDATED VIA CRYO-EM. Harsh Dutta , Nikhil Bharambe, Sandip Basak 494-Pos Board B306 ENGINEERING NOVEL MUTANT PROTEINS OF THE NA + - I - SYMPORTER (NIS) TO BROADEN RADIOIODIDE THERAPY BEYOND THYROID CAN CER. Alejandro Llorente-Esteban , Haswitha Sabbineni, Kendra Hoff smith, Rían Manville, David López-González, Andrea Reyna-Neyra, Alfonso Leyva, Geoffrey Abbott, Mario A. Bianchet, Nancy Carrasco 495-Pos Board B307 MOLECULAR SIMULATIONS OF PROTON-COUPLED NEUROTRANSMIT TER TRANSPORT BY VMAT2. Carl-Mikael Suomivuori 496-Pos Board B308 MOLECULAR BASIS OF SUBSTRATE SPECIFICITY EVOLUTION IN ABCG2. Ever O’Donnell , Xujia Zhou, Sook Wah Yee, Kathy Giacomini, Robert Stroud, Willow Coyote-Maestas 497-Pos Board B309 STRUCTURAL BASIS OF UNCOUPLING IN A CLC TRANSPORTER. Sangyun Lee , Olga Boudker, Alessio Accardi Other Channels (Boards B310 - B318) 498-Pos Board B310 HIGH THROUGHPUT CHARACTERIZATION OF CHANNELRHODOPSIN-2 USING AN AUTOMATED PATCH CLAMP SYSTEM. Timothy Strassmaier , Tom Goetze, Søren Friis, Alison Obergrussberger, Irene Lu, Aviv Korman, Ki Pyo, Florian Hintermaier, Fridolin Kutterer, Stephan Holzhauser, Mi chael George, Niels Fertig 499-Pos Board B311 A HIGH-THROUGHPUT SCREENING METHOD IDENTIFIES MARINE DERIVED SMALL MOLECULE INHIBITORS OF HV1 CHANNELS. Punyanuch Hua , Ruiming Zhao, Jehad Almaliti, William Gerwick, Steve A. Goldstein 500-Pos Board B312 EVALUATING THREE MODELS OF THE HHV1 DIMER INTERFACE. Thi Huong Quynh Nguyen , J. Alfredo Freites, Douglas J. Tobias, Francesco Tombola

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