BPS2026 Program Book

501-Pos Board B313 THE EXTRACELLULAR TURRET IS ESSENTIAL FOR GATING IN BOTH HCN AND KV CHANNELS. Kaei Ryu , Go Kasuya, Koichi Nakajo 502-Pos Board B314 COMPUTATIONAL SCANNING OF PORE-LINING RESIDUES IN CLAUDIN-15 ION CHANNELS AND THEIR EFFECT ON CHANNEL SELECTIVITY. Sarah McGuinness , Maryam Mohebbi, Amir Shariat Gonabadi, Fatemeh Khalili-Araghi 503-Pos Board B315 NUCLEAR PORE TRANSPORT: WHICH IMPORTIN-Β BINDING SITES GOVERN FG-NUP TRAVERSAL? Abdullah Mansour , Atsushi Matsuda, Mohammad Mofrad 504-Pos Board B316 Travel Award Winner THE FLUORESCENT NONCANONICAL AMINO ACID ACRIDONYLALANINE REPORTED CONFORMATIONAL CHANGES IN THE HUMAN VOLTAGE GATED PROTON CHANNEL (H V 1). Emerson M. Carmona , Charlie DeFre est, William N. Zagotta, Sharona E. Gordon 505-Pos Board B317 Travel Award Winner A TRAP-AND-RELEASE MECHANISM DRIVES VOLTAGE-DEPENDENT TRANSPORT IN A LARGE-PORE CHANNEL. Pablo S. Gaete , Cynthia I. Fernandez, Deepak Kumar, Yun Lyna Luo, Jorge E. Contreras 506-Pos Board B318 MATHEMATICAL MODELING OF GAP JUNCTION CHANNEL VOLTAGE GATING: FROM SINGLE CHANNELS TO EXCITABLE TISSUES. Mindaugas Snipas , Tadas Kraujalis, Lukas Gudaitis, Orestas Makniusevicius, Kestutis Maciunas, Lina Kraujaliene, Vytas Verselis Cardiac Muscle Mechanics and Structure (Boards B319 - B337) 507-Pos Board B319 CRYO ELECTRON MICROSCOPY REVEALS THE INTERACTION OF THE CARDIAC MYOSIN BINDING PROTEIN C N-TERMINAL DOMAINS WITH THE NATIVE CARDIAC THIN FILAMENT. Cristina M. Risi, Tyler Nguyen, Thomas. A Bunch, Victoria C Lepak, Julian Stelzer, Brett A Colson, Vitold Board B320 THE ROLE OF MIDDLE DOMAINS OF MYBP-C IN THE RELAXATION KINET ICS OF SINGLE CARDIAC MYOFIBRILS. Alexey V. Dvornikov , Samantha P. Harris 509-Pos Board B321 DEEP LEARNING MODEL OF CARDIAC MUSCLE CONTRACTION. Yasser Aboelkassem 510-Pos Board B322 MODELING MYOSIN’S DEPARTURE FROM THE IHM WITH MOLECULAR SIMULATION. Matthew C. Childers , Michael A. Geeves, Michael Regnier 511-Pos Board B323 STABILITY OF THE PROXIMAL S2 DIMER AND ITS INTERACTION WITH S1 IN HUMAN Β-CARDIAC MYOSIN. Aarushi Naskar , Yuri Nesmelov 512-Pos Board B324 PROGRESSIVE CHRONIC STRETCH PROVOKES HYPO-CONTRACTILITY IN DESMOPLAKIN-DEFICIENT ENGINEERED HEART TISSUE. Xianmu Li , Ilhan Gokhan, Xia Li, Fadi Akar, Stuart G. Campbell 513-Pos Board B325 REDUCED POWER IN AFTERLOADED TWITCH CONTRACTIONS REFLECTS INCOMPLETE ACTIVATION OF MYOFILAMENTS. Kenneth S. Campbell , Kerry S. McDonald E. Galkin 508-Pos

514-Pos Board B326 Y261 TROPOMYOSIN VARIANTS ALTER CALCIUM SENSITIVITY AND RE LAXATION KINETICS VIA DISRUPTED TROPONIN T INTERACTIONS. Sanjana U. Nistala , Alfredo Bongiorno, Michael J. Rynkiewicz, William Lehman, Jeffrey R. Moore, Stuart G. Campbell 515-Pos Board B327 BIOPHYSICAL MECHANISMS OF DYSFUNCTION FOR THE CARDIAC TROPONIN C G34R AND G34S VARIANTS. Vinay Jani , Kristina B. Kooiker, Stephanie Neys, Anthony Asencio, An-Yue Tu, Michael Regnier, Farid Moussavi-Harami 516-Pos Board B328 SCREENING SINGLE NUCLEOTIDE CHANGES TO TROPONIN T TO IDEN TIFY CARDIOMYOPATHY MUTANTS. Hana Hamid, William Lehman, Michael J. Rynkiewicz 517-Pos Board B329 PENICILLIN-STREPTOMYCIN DECREASES FORCE OUTPUT OF HIPSC DERIVED CARDIOMYOCYTES. Anthony Asencio , Kristina B. Kooiker, Tim McMillen, Andrew P. Wescott, Michael Regnier, Farid Moussavi-Harami 518-Pos Board B330 Travel Award Winner ADIPONECTIN DEFICIENCY ACCELERATES CROSSBRIDGE KINETICS AND REDUCES FORCE IN CARDIAC MUSCLE FIBERS, LIMITING EXERCISE ADAPTATIONS IN MICE. Steven Medarev , Maicon Landim-Vieira, Ronnie Chastain, Flair Paradine, Christopher N. Toepfer, Judy Delp, J. Renato D. Pinto 519-Pos Board B331 THE DILATED CARDIOMYOPATHY-ASSOCIATED MYH7 MUTATION R369Q EXHIBITS VARIED CONTRACTILE PHENOTYPES IN A MULTISCALE STUDY OF STEM CELL-DERIVED CARDIOMYOCYTES. Aditi M. Prabhala , Tim Mc Millen, Kristina B. Kooiker, Kerry Y. Kao, Farid Moussavi-Harami, Michael Regnier 520-Pos Board B332 TARGETED CORRECTION OF A MYOSIN DCM MUTATION WITH 2’-DEOXY ATP. Tristan W. Wasley , Matthew C. Childers, Kerry Y. Kao, Michael Regnier 521-Pos Board B333 THE G256E HCM MUTATION PROLONGS RELAXATION VIA ALTERED NUCLEOTIDE HANDLING. Kerry Y. Kao , Matthew C. Childers, Divya Pathak, Rama Reddy Goluguri, Tim S. McMillen, Kathleen M. Ruppel, James A. Spudich, Michael Regnier 522-Pos Board B334 THE HYPERTROPHIC CARDIOMYOPATHY MUTATION G768R MAKES CARDIAC MYOSIN A HIGH DUTY RATIO MOTOR. Divya Pathak, Tugba N. Ozturk, Matthew C. Childers, Michael Regnier, Chao Liu , James A. Spudich, Kathleen Ruppel 523-Pos Board B335 THE EFFECT OF SINGLE MYOSIN-HEADS ON THE POSITION OF TROPO MYOSIN ON ACTIN. Olga E. Karpicheva , Michael J. Rynkiewicz, William Board B336 DECODING THE MOLECULAR AND FUNCTIONAL CONSEQUENCES OF INTRINSIC DISORDER IN CARDIAC TROPONIN T. Ella I. Mozier , Jasmine Cubuk, Lina Greenberg, Melissa D. Stuchell-Brereton, Andrea Soranno, Michael J. Greenberg 525-Pos Board B337 SPATIALLY EXPLICIT MCMC MODEL OF COMBINED THIN AND THICK FILAMENT COOPERATIVITY. Joy Pajarla , Stuart G. Campbell Lehman 524-Pos

F R I D A Y

S U N D A Y

38