BPS2026 Program Book

Membrane Pumps, Transporters, and Exchangers (Boards LB72 - LB81) L2533-Pos Board LB72 INVESTIGATING THE PHYSIOLOGICAL SUBSTRATES OF A PUTATIVE BACTERIAL SEROTONIN TRANSPORTER. Antoniya A. Aleksandrova , Jonathan B. Lynch, Lucy R. Forrest L2534-Pos Board LB73 FROM SEQUENCE TO MECHANISM: INSIGHTS INTO PROTON COUPLING IN CYSTINOSIN FROM MULTISCALE MOLECULAR SIMULATIONS. Jona than D. Colburn, Philip C. Biggin L2535-Pos Board LB74 DIRECT DETECTION OF POLYAMINE TRANSPORT ACROSS MEM BRANES. Sean R. Cleary , Cristina Moreno Vadillo, Shubhra Srivastava, Pablo Miranda, Miguel Holmgren L2536-Pos Board LB75 A STEROIDAL NA/K-ATPASE INHIBITOR MARINOBUFAGENIN IS AN EXTRACELLULAR VESICLE CARGO IN OBESITY-ASSOCIATED CHRONIC KIDNEY DISEASE. Beianka Tomlinson , Carla Rocha Dos Santos, Wen Wei, Christopher H. Morrell, Edward G. Lakatta, Olga V. Fedorova L2537-Pos Board LB76 NEW DISEASE-INDUCING MUTATIONS OF THE CLC-7 LYSOSOMAL TRANSPORTER IN MUTANT HOMODIMERS AND HETERODIMERS. Paolo Zuccolini , Jacob K. Hilton, Joseph A. Mindell L2538-Pos Board LB77 STRUCTURAL DETERMINANTS OF CLC-7 VOLTAGE DEPENDENCE, GAT ING, AND CHLORIDE/PROTON COUPLING. Jacob K. Hilton , Yifei Lin, Eric Sefah, Justin Deme, Jo L. Parker, Matthew Langton, Michael Grabe, Susan Lea, Simon Newstead, Joseph A. Mindell L2539-Pos Board LB78 STRUCTURES OF THE TWIN-ARGININE TRANSLOCATION PATHWAY CORE COMPLEX FROM GRAM-POSITIVE AND GRAM-NEGATIVE BACTE RIA. Owain J. Bryant , Justin Deme, Ben C. Berks, Susan M. Lea L2540-Pos Board LB79 PROTONATION-DEPENDENT ENGAGEMENT OF ACIDIC RESIDUES DISTINGUISHES SUBSTRATES FROM INHIBITORS IN VESICULAR AMINE TRANSPORTERS. Wutong Zhou , Jing Li L2541-Pos Board LB80 UNCOVERING VULNERABILITIES IN MYCOBACTERIUM TUBERCULOSIS EFFLUX PROTEIN A. Nitesh K. Khandelwal , Meghna Gupta, Deborah T. Hung, Robert M. Stroud L2542-Pos Board LB81 MOLECULAR AND STRUCTURAL INSIGHTS INTO CDR1-MEDIATED DRUG RESISTANCE IN CANDIDA AURIS. Darpan Raghav , Md Shamiul Islam Rasel, Thomas Tomasiak Other Channels (Boards LB82 - LB83) L2543-Pos Board LB82 COMBINED SINGLE-MOLECULE OPTICAL AND ELECTRICAL STRATEGIES FOR MEASURING DIFFUSION AND THE RATIO OF OPEN-TO-CLOSED ION CHANNELS IN FREESTANDING LIPID BILAYERS. Kayla R. Sennese , Madi son A. Handyside, Joseph S. Harvey, SeeEun Lee, Kathryn A. Michael, Lisa M.K. Burden, Daniel L. Burden

L2544-Pos Board LB83 LOSS OF VOLTAGE-SENSING PHOSPHATASE DISRUPTS RENAL SOLUTE HOMEOSTASIS IN MICE. Tiffany Chan , Victoria C. Young, Susy C. Kohout Cardiac Muscle Mechanics and Structure (Boards LB84 - LB84) L2545-Pos Board LB84 STRUCTURAL POLYMORPHISM OF THE CARDIAC ACTIN Y166C AS A MOLECULAR BASIS FOR HYPERTROPHIC CARDIOMYOPATHY. Hsiang Ling Huang , Andrejus Suchenko, Mohan K. Balasubramanian, Sarah M. Heissler, Krishna Chinthalapudi Kinesins, Dyneins, and Other Microtubule-based Motors (Boards LB85 - LB89) L2546-Pos Board LB85 STRUCTURAL BASIS OF AUTOINHIBITION AND ACTIVATION OF HETERO TRIMERIC KINESIN-2, KIF3A/B/KAP3 COMPLEX. Md Ashaduzzaman , Aryan Taheri, Yuqi Tang, Stephen D. Fried, Jawdat Al-Bassam L2547-Pos Board LB86 ATP-DEPENDENT MICROTUBULE RIBBON SLIDING EXTENDS THE HELI CAL PITCH OF SPIROSTOMUM AMBIGUUM DURING ELONGATION. Ko suke Nakamura, Seiji Sonobe, Kazuhiro Oiwa L2548-Pos Board LB87 ROLES OF MICROTUBULES AND LIS1 IN THE ASSEMBLY OF DYNEIN TRANSPORT MACHINERY. Kai Zhang L2549-Pos Board LB88 TUBULIN GLUTAMYLATION INCREASES TAU CONDENSATE DIFFUSIVITY AND ENABLES KINESIN-3 MOTILITY. Ilia Zhernov , Antonina Roll-Mecak L2550-Pos Board LB89 DOUBLE-STRANDED DNA SPRING TO INVESTIGATE THE LOAD-DEPEN DENCE OF THE DYNEIN OFF-RATE. Nathan L. Wolfe , William Hancock Myosins (Boards LB90 - LB93) L2551-Pos Board LB90 QUANTITATIVE IN VITRO IMAGING OF NON-MUSCLE MYOSIN 2A SINGLE FILAMENTS VIA SIM MICROSCOPY. Joseph A. Cirilo , James R. Sellers L2552-Pos Board LB91 SINGLE MOLECULE STUDIES OF THE UNIQUE MECHANICAL STATE OF HUMAN MYOSIN-6 USING NEGATIVE-STAIN EM AND MINFLUX NANOS COPY. Philip Bleicher , Yasuharu Takagi, Neil Billington, Jan Otto Wirth, Jessica Matthias, James R. Sellers L2553-Pos Board LB92 ISOFORM-SPECIFIC FINE TUNING OF NONMUSCLE MYOSIN-2A BY THE ESSENTIAL LIGHT CHAIN. Isabella M. Kolodny , Charlotte Rose, Angelina Ramirez-Navarro, Giovanna Grandinetti, Krishna Chinthalapudi, Sarah Board LB93 BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE C. ELEGANS NONMUSCLE MYOSIN-2 MOTOR DOMAIN. Meghan Novotny , Julia Rose, Giovanna Grandinetti, Krishna Chinthalapudi, Sarah M. Heissler M. Heissler L2554-Pos

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