BPS2026 Program Book

Graduate Student Breakfast 7:30 am - 8:30 am, Esplanade, Room 155

662-SympSelect 9:30 am INSOLUBLE PROTEINS COMPETE FOR RNA BINDING TO ASSEMBLE MUL TILAYERED CONDENSATES. Wilton T. Snead , Mary K. Skillicorn, Krishna Shrinivas, Amy S. Gladfelter 663-Symp 9:50 am VARIABLE 1D SEQUENCES AND CONSERVED 2D/3D STRUCTURES OF DNA-PACKAGING ATPASE-DRIVING NCRNA NANOSTRUCTURES FOR TRACKING THE EVOLUTION AND ORIGIN OF ORGANISMS---DISCOVERY OF 12 NEW NCRNA-NANOSTRUCTURES FOR DEVELOPING AND DELIV ERING POTENT THERAPEUTICS. Kai Jin, Margaret Bohmer, Peixuan Guo Platform Protein Structure Prediction and Design 8:15 am - 10:15 am, Room 201/202/203 Co-Chairs Kathryn Shelley, University of Washington, USA Lee A. Solomon, George Mason University, USA 664-Plat 8:15 am LARGE-SCALE PREDICTIONS OF ALTERNATIVE PROTEIN CONFORMA TIONS. Myeongsang Lee , Joseph W. Schafer, Jeshuwin D. Prabakaran, Devlina Chakravarty, Madeleine F. Clore, Lauren L. Porter 665-Plat 8:30 am AF2CHI: PREDICTING PROTEIN SIDE-CHAIN ROTAMER DISTRIBUTIONS WITH ALPHAFOLD2. Matteo Cagiada, Emil Thomasen, Sergey Ovchin nikov, Charlotte M. Deane, Kresten Lindorff-Larsen 666-Plat 8:45 am ALPHAFOLD CAN BE USED TO PREDICT THE OLIGOMERIC STATES OF PROTEINS. Yiechang Lin, Ciara Wallis , Ben Corry 667-Plat 9:00 am DE NOVO DESIGN OF LIGHT-DRIVEN PROTEIN MOTOR DOMAINS. Kathryn Shelley , Cullen Demakis, David Baker 668-Plat 9:15 am PROBABILISTIC DEEP LEARNING ENABLES THE DATA-DRIVEN DESIGN OF DISORDERED PROTEINS. Jeffrey M. Lotthammer , Borna Novak, Alex S. Holehouse 669-Plat 9:30 am DE NOVO DESIGN OF PROTEIN BINDERS FOR PROGRAMMABLE CON TROL OF BIOMOLECULAR CONDENSATES. Duc Duy Vu , Marie-Aude Plamont, Enzo Rakotomalala-lo, Sadek Amhaz, Zoher Gueroui, Massimil iano Bonomi 670-Plat 9:45 am A MODEL FOR THE SEQUENCE SPACE OF A PROTEIN FAMILY. Emily C. Hinds , Yaakov Kleeorin, Michael Socolich, Rama Ranganathan 671-FlashTalk 10:00 am FROM UBIQUITIN TO BARREL: COMPUTATIONAL DESIGN OF A DE NOVO PROTEIN FOLD-SWITCH. Lisa Schmidt , Bert L. de Groot 672-FlashTalk 10:05 am DECONSTRUCTING THE COMPLEXITY: UNDERSTANDING ATP BINDING WITH DE NOVO DESIGN AND COMPONENT PARTS. Lee A. Solomon , Robert Spaine, Kenneth Foreman, Qinyi Zhong, Amber Middleton 673-FlashTalk 10:10 am DMCLOUD: LOCAL MODEL-MAP FITTING FOR LARGE MACROMO LECULAR STRUCTURE IN CRYO-EM MAPS. Genki Terashi , Xiao Wang, Yuanyuan Zhang, Han Zhu, Daisuke Kihara

M O N D A Y

This breakfast presents an opportunity for graduate student Annual Meeting attendees to meet and discuss the issues they face in their cur rent career stage. Limited to the first 100 attendees. Moderators Angela Greenman, The University of Arizona, USA Charlotte Smith, University of California, Davis, USA Speakers Sarah Smaga, BPS Congressional Fellow, Office of Representative Mad eleine Dean (D-PA-04), USA Kerry McDonald, University of Missouri, USA Diego Lopez Mateos, University of California, Davis, USA Registration/Exhibitor Registration 7:30 am - 5:00 pm, South Lobby Poster Viewing 8:00 am - 10:00 pm, Exhibit Halls ABC Symposium Future of Biophysics Burroughs Wellcome Fund 8:15 am - 10:15 am, Room 301/302 Co-Chairs Ariane Briegel, Institut Pasteur, France Ilya Levental, University of Virginia, USA No Abstract 8:15 am INTEGRATIVE STRUCTURAL MODELING OF HETEROGENEOUS LIPOPRO TEIN ASSEMBLIES. Keith Cassidy No Abstract 8:45 am DECODING RNA PROOFREADING MECHANISM IN LARGE RNA GENOME VIRUSES. Chang Liu No Abstract 9:15 am DATA-DRIVEN MODELING OF INTRINSICALLY DISORDERED REGIONS IN PHASE SEPARATION. Giulio Tesei No Abstract 9:45 am QUANTITATIVELY MODELING THE ENSEMBLE-FUNCTION RELATIONSHIP OF THE HIV 5’-LEADER RNA IN CELLS. Megan Ken Symposium RNA Dynamics and Phase Transitions 8:15 am - 10:15 am, Room 303/304 Chair Peixuan Guo, The Ohio State University, USA No Abstract 8:15 am PROGRAMMABLE ARTIFICIAL RNA CONDENSATES IN MAMMALIAN CELLS. Elisa Franco 660-Symp 8:40 am UNTANGLING THE FOLDING AND AGGREGATION OF TRIPLET REPEAT RNA. Brett O’Brien, Christian M. Kaiser, Sarah Woodson 661-Symp 9:05 am SYNTHETIC CELLS FROM PHASE-SEGREGATED NUCLEIC ACIDS. Andreas Walther

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