BPS2026 Program Book

Platform Membrane Receptors, Signal Transduction and Mechanosensation 8:15 am - 10:15 am, Room 204/205/206 Co-Chairs Maria Falzone, University of Texas Health Science Centre, USA Danielle R. Latham, Clemson University, USA 674-Plat 8:15 am STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF SCUBE3 PROTEIN - A NOVEL ONCOGENIC LIGAND FOR EGFR. Rahul M. Mojidra , Deepika Singh, Manjeet Rao, Maria E. Falzone 675-Plat 8:30 am DEEP MUTATIONAL PHARMACOLOGY REVEALS THE MOLECULAR BASIS OF OPIOID AGONISM. Matthew Howard , Jerome Freudenberg, Zara Weinberg, Harold Pimentel, Justin English, Aashish Manglik, Willow Coyote-Maestas 676-Plat 8:45 am COMPARATIVE PROXIMITY BIOTINYLATION MAPPING REVEALS THE ROLE OF ENDOLYSOSOMAL RETROFUSION IN INTRACELLULAR TRAF FICKING OF MONOCYTIC GPCRS. Alexis Lona , Thomas Shroka, Siyi Gu, Huaping Qin, Luya Wei, Sofia Endzhievskaya, Tony Ngo, Thy Nguyen, Mian Huang, Willow Carretero Chavez, JoAnn Trejo, Tracy M. Handel, Irina Kufareva 677-Plat 9:00 am Travel Award Winner IN SILICO HIERARCHICAL AND CALCIUM-DEPENDENT MECHANICS OF INNER-EAR TIP LINKS UNDER RESTING TENSION. Haosheng Wen , Carter T. Wheat, Jasanvir S. Sandhu, Elakkiya Tamilselvan, Pedro De-la-Torre, Joseph C. Sudar, Travis Harrison-Rawn, Marissa Boyer, Qurat Ashraf, Marcos M. Sotomayor 678-Plat 9:15 am THE 3D STRUCTURE OF THE AUDITORY SYSTEM’S MECHANOSENSITIVE HAIR BUNDLE INCREASES ITS DEFLECTION SENSITIVITY AND DYNAMIC RANGE. Zenghao Zhu, Wisam Reid, Shefin Sam George, Victoria Ou, Daibhid O Maoileidigh 679-Plat 9:30 am Travel Award Winner CHIMERIC ANTIGEN RECEPTORS TRANSMIT COSTIMULATORY DOMAIN DEPENDENT PICONEWTON FORCES TO THEIR TARGET. Hemakshi Mishra , Lauren Mahoney, Dominique Smith, Luke Kalcheim, Monica Umesh, Kartikey Kansal, Nat Murren, Myrna Chang, Rebecca Richards, Joshua Brockman 680-Plat 9:45 am SEX- AND AGE-DEPENDENT MECHANISMS OF THE MECHANO-CHRONO TROPIC RESPONSE IN THE SINOATRIAL NODE. Jenson D. Aaron , Aleksei Averin, Isabella Doherty, Thomas Schrauth, Roman Y. Medvedev, Conor J. Neill, Stefano Morotti, Eleonora Grandi, Alexey V. Glukhov 681-FlashTalk 10:00 am ACTIN CONTRACTILITY AND CLATHRIN-COATED PITS ESTABLISH MID PLANE-PEAKED APICO-BASAL TENSION PROFILES IN HELA CELLS. Tan moy Ghosh , Anisha Majhi, Avijit Kundu, Ayan Banerjee, Bidisha Sinha 682-FlashTalk 10:05 am LIVE-CELL COMPATIBLE EXPANSION VIA HYDROGELS ON A TENSILE IRIS-STRETCHER. Danielle R. Latham , Vignesh Venkataramani, Marouen Zammali, Ramita Arampongpun, Tejasvin Shrikanth, Roberto C. Andre sen Eguiluz, Laura C. Caba Sanchez, Lydia Kisley

683-FlashTalk 10:10 am SPATIAL RESTRICTION OF EGFR ACTIVATION FACILITATES THE SUPPRES SION AND EXTENSION OF CELL SIGNALING. Nicholas Duong , Aidan Brown Platform Membrane Structure and Organization II 8:15 am - 10:15 am, Room 207/208 Co-Chairs Sekou A. Koisiah, Indiana University, USA Van A. Ngo, Oak Ridge National Laboratory, USA 684-Plat 8:15 am THERMAL ACTUATION DRIVES HEXAGONAL PEPTIDE DOMAIN FORMA TION IN PEPTIDE POLYMER AMPHIPHILE-LIPID HYBRID MEMBRANES. Bengu S. Sengul , Nurila Kambar, Yingying Chen, Yoo Kyung Go, Chris Evans, Cecilia Leal 685-Plat 8:30 am CONDENSATE SIZE REGULATION BY MEMBRANES REVEALED THROUGH SYNTHETIC CELL ASSEMBLY. Karthika S Nair 686-Plat 8:45 am CONSTITUTIVE PLASMA MEMBRANE RAFT FORMATION IN SACCHARO MYCES CEREVISIAE AND OTHER FUNGI. Betty B. Du , Erwin London 687-Plat 9:00 am AMPHIPHILIC CO-SOLVENTS ALTER LATERAL MEMBRANE ORGANIZA TION. Luoxi Tan , Haden L. Scott, Micholas Dean Smith, Sai Venkatesh Pingali, Xiaolin Cheng, Hugh M. O’Neill, John Katsaras, Jeremy C. Smith, Brian H. Davison, Jonathan D. Nickels 688-Plat 9:15 am ALL-ATOM MODELS OF CYTOPLASMIC VERSUS EXOPLASMIC NANOME TER ASYMMETRIC VESICLES. Van A. Ngo 689-Plat 9:30 am ASYMMETRY AND HETEROGENEITY IN THE PLASMA MEMBRANE. Teppei Yamada , Wataru Shinoda 690-Plat 9:45 am TWO-STAGE MECHANICAL RESPONSE OF LIPID MEMBRANES TO ASYM METRY. Emad Pirhadi , Xin Yong 691-FlashTalk 10:00 am THE FUNCTIONAL ROLE OF LOCALIZED PLASMA MEMBRANE SCRAM BLING IN IMMUNE CELL ACTIVATION. Daryna Sputay , Sze Ham Chan, Kandice R. Levental, Ilya Levental 692-FlashTalk 10:05 am MEMBRANE STRUCTURE AND CHIRAL LIPID-CHOLESTEROL INTERAC TIONS. Ethan Kimelheim , Edward R. Lyman 693-FlashTalk 10:10 am INTERACTION OF PERFLUOROALKYL SUBSTANCES WITH LIPID MEM BRANES. Sekou A. Koisiah , Emmanuel O. Osei, Andres T. Cavazos, Stephen R. Wassall, Horia I. Petrache

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