BPS2026 Program Book

Exhibitor Presentation Nanion Technologies 10:30 am - 12:00 pm, Esplanade, Room 158 Electrophysiological Tools for Advancing Ion Channel and Transporter Drug Discovery Speaker: Tim Strassmaier, Director of Scientific Operations, Nanion Technologies For over 2 decades, Nanion Technologies has been providing diverse solutions for electrophysiologists worldwide. We aim to implement in novative technologies for ion channel research, automated patch clamp (APC) electrophysiology, cell viability and contractility monitoring, and electrogenic transporter studies, across various throughput formats. Our symposium will start with an introduction by Tim Strassmaier who will describe the latest advances in Nanion’s assays and product portfolio, followed by our speakers, whose work focuses on ion channel and trans porter research. Ion Channels in Drug Discovery: Current Landscape and Future Directions Speaker: Marc Rogers, Ion Channel Drug Discovery Consultant, Albion Drug Discovery Services Ltd 2025 was a stand-out year for ion channel drug approvals, with two novel ligands making it to market as well as a re-purposed drug ap proved for rare disease. The momentum continues into 2026 with a large number of preclinical and clinical programs using small molecule, gene therapy, antibody and protein degradation modalities to modulate ion channel expression and function across a wide range of common and rare disease indications. Alongside popular targets such as Nav1.8, Kv7.x, GABA-A and GluR channels and receptors, commercial and academic drug discovery groups are using in vitro and in silico screening methods to develop novel ligands for a wide range of new transmem brane transport proteins in organelles (TMEM175, TRPML1, TPC, RyR), on the plasma membrane (K2P, KNa, Kv3.x, ASIC, SLCs, KCC2) and in cilia (TRPP1/2). Introducing the Next Generation of Automated Patch Clamp for Ion Channel Drug Discovery Speaker: Alison Obergrussberger, Director of Scientific Sales and Cus tomer Engagement, Nanion Technologies Twenty years ago, the Patchliner set a new benchmark as a fully auto mated patch clamp system capable of recording from up to eight cells simultaneously. Since then, it has become a trusted workhorse across academia and industry - supporting everything from routine cardiac safety assays to complex biophysical investigations of voltage-gated ion channels and heat activation of TRP channels. Now, two decades later, the Patchliner is undergoing a major transformation. With significant im provements in assay versatility, hardware design, and software perfor mance, the next-generation Patchliner sets a new standard for precision, efficiency, and ease of use in automated electrophysiology. Interrogating Transporter Oligomerization and Function Using SURFE2R N1 Speaker: Janice Robertson, Associate Professor, Department of Bio chemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis Transporters often assemble as oligomers even when each subunit appears to contain its own transport pathway. This raises the question of whether oligomerization is a mechanism for modulating transport activity. Here, we investigate this by studying two homodimer systems: the CLC-ec1 chloride/proton antiporter and the AdiC arginine/agmatine antiporter. Monomer-dimer populations of fluorophore conjugated

proteins are examined in membranes using TIRF microscopy and single molecule photobleaching. In parallel, transport is assessed using the SURFE2R N1 which provides a versatile functional assay to compare different transporter types and substrates under a wide variety of envi ronmental conditions. Symposium Novel Protein Machines 10:45 am - 12:45 pm, Room 301/302 Chair Cees Dekker, Delft University of Technology, The Netherlands No Abstract 10:45 am PROTEIN DESIGN FOR THE DEVELOPMENT OF NEW ANTIVIRALS AND VACCINES. Eva-Maria Strauch No Abstract 11:10 am LOOP EXTRUSION: FROM GENOME FOLDING TO GENE REGULATION. Leonid Mirny 714-Symp 11:35 am DNA LOOP EXTRUSION AND OBSTACLE BYPASS BY THE WADJET SMC MOTOR. Stephan Gruber 715-SympSelect 12:00 pm SINGLE-MOLECULE DISSECTION OF THE PAR POLARITY MACHINERY. Sheng-Ping Hsu, Lars Deutz, Daniel J. Dickinson 716-Symp 12:20 pm SINGLE-MOLECULE BIOPHYSICS STUDIES OF DNA LOOP EXTRUSION BY SMC MOTOR PROTEINS. Cees Dekker Symposium Membrane Contacts and Lipid Transfer Across and Between Membranes 10:45 am - 12:45 pm, Room 303/304 Chair Yongli Zhang, Yale University, USA No Abstract 10:45 am IMAGING LIPIDS. Andre Nadler 717-Symp 11:10 am MECHANISMS OF PHOSPHOLIPID ASYMMETRY IN THE PLASMA vMEMBRANE. Katsumori Segawa 718-Symp 11:35 am SHAPING THE MEMBRANE PROTEOME WITH RHOMBOID-LIKE PROTE ASES AND PSEUDOPROTEASES. Matthew Freeman 719-SympSelect 12:00 pm MEMBRANE THINNING: A SHARED MECHANISM BY SCRAMBLASES, INSERTASES, AND TRANSLOCASES. Robert Vacha , Ladislav Bartoš 720-Symp 12:20 pm DRIVING FORCES UNDERLYING MEMBRANE FUSION AND BULK LIPID TRANSPORT. Yongli Zhang

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