Biophysical Society 2020 Annual Meeting

Exhibitor Presentation LUMICKS 5:30 pm - 7:00 pm, Room 33A Breaking the Barriers: Providing the Full Workflow for Dynamic Single-Molecule Research from Sample to Publication Here, we present our newest developments to further support dis- coveries in the fields of biology and biophysics. Our aim is to enable faster, easier, and more reliable than ever single-molecule research – from sample to publication – by extending the full experimental workflow with new services and open-access initiatives. To decipher complex molecular interactions, you need to be able to observe the same biological process from multiple points of view. Using LUMICKS’ groundbreaking C-Trap™ Optical Tweezers –Fluo- rescence & Label-free Microscopy, you can simultaneously visualize individual molecules in real time and measure biological processes in greater detail. The combination of live-imaging and measure- ments has proven to be a research game changer. With the ever-increasing pressure to perform breakthrough discov- eries in the least amount of time, LUMICKS brings you an instru- ment with unprecedented high precision, accuracy, reliability, and the shortest time to result. The C-Trap gives you access to three key features: stable and precise sample manipulation and mea- surements, a wide variety of visualization capabilities, and a high throughput experimental workflow. With the technology in hand, the major barriers that still remain in dynamic single-molecule experimentation are caused by tedious sample preparation and non-standardized data analysis methods. With ready-to-use kits, tailored sample preparation support, and easy-to-use data analysis, scientists can now focus more on their biological questions and generate the next wave of scientific discov- eries in the least amount of time. Join our presentation to learn about our new single-molecule bio- chemistry services and our open-access user community for experi- ment automation and data analysis in single-molecule research. Speakers Olivier Heyning, Chief Executive Officer & Founder, LUMICKS Emmanuel Lissek, Application Scientist, LUMICKS Ali Raja, Director Americas, LUMICKS Dinner Meet-Ups 6:00 pm - 6:30 pm, Society Booth/Lobby G Interested in making new acquaintances and experiencing the cuisine of San Diego? Meet at the Society Booth Monday and Tuesday at 6:00 Pm, where a BPS member will coordinate dinner at a local restaurant. Awards and 2020 Biophysical Society Lecture 8:00 pm - 9:00 pm, Ballroom 20ABCD PRESENTATION OF AWARDS 8:00 pm 932.01-bpsl 8:15 pm FROM SINGLE MOLECULE BIOPHYSICS TO SINGLE CELL GENOMICS: WHEN STOCHASTICITY MEETS PRECISION Xiaoliang Sunney Xie Reception and Dance

928-plat 4:45 pm A LIPID RECOGNITION SITE AT A TRANSMEMBRANE HELIX KINK SHAPES THE AGONIST RESPONSE OF A PENTAMERIC LIGAND-GATED ION CHAN- NEL.  John E. Baenziger , Camille M. Henault, Cedric Govaerts, Argel Estrada, Joseph Lynch, Daniel Bertrand, Els Pardon, Genevieve Evans, Kris- ten N. Woods, Benjamin W. Elberson, Luis G. Cuello, Grace H. Brannigan, Hugues Nury, Jan Steyaert, Chris Ulens 929-plat 5:00 pm THE MOLECULAR MECHANISMS OF CHOLESTEROL REGULATION OF KIR CHANNELS REVEALED BY DIRECT AND QUANTITATIVE APPROACHES.  Sun Joo Lee , Zi-Wei Chen, Melissa Budelier, Kathiresan Krishnan, Douglas F. Covey, Alex S. Evers, Colin G. Nichols 930-plat 5:15 pm MECHANISM OF MODULATION OF AMPA RECEPTORS BY TARP-Γ8.  Elisa Carrillo , Sana A. Shaikh, Vladmir Berka, Linda M. Nowak, Vasanthi Jayaraman 931-plat 5:30 pm MECHANISMS OF ACTIVATION AND DESENSITIZATION OF FULL-LENGTH GLYCINE RECEPTOR IN MEMBRANES.  Arvind Kumar , Sandip Basak, Shanlin Rao, Yvonne W. Gicheru, Megan Mayer, Mark S. Sansom, Sudha Chakrapani 932-plat 5:45 pm MAPPING PH-DEPENDENT STATE TRANSITIONS OF A PENTAMERIC LIGAND-GATED ION CHANNEL THROUGH MARKOV STATE MODELING.  Cathrine Bergh , Laura Orellana, Stephanie A. Heusser, Rebecca J. Howard, Erik Lindahl Career development and networking is important in science, but can be a big time commitment. Here we offer refreshments and the chance to speed network, an exciting way to connect with a large number of bio- physicists (including Biophysical Society committee members) in a short amount of time. Mid-career and more experienced scientists can learn how to get more involved in the Society or network for open positions in their labs. Early career scientists can discuss career goals and challenges, get advice on tenure or grant writing, or find out how to gain recognition for their work. Graduate students and postdocs can make contacts to find their next position. After introductions, each person will have short 3-5 minute meetings with consecutive new contacts. During this time you can exchange information and ask questions. When time is up, you select the next person to talk to. By the end of the event, each participant will have had meaningful interactions with over half a dozen colleagues and the opportunity to meet many more. It’s that simple! Speed Networking 4:30 pm - 6:00 pm, Lobby H

M O N D A Y

Exhibitor Presentation Molecular Devices 4:30 pm - 6:00 pm, Room 33C

Empower Your Electrophysiology Studies Using New Axon pCLAMP 11 Software and HumSilencer Adaptive Noise Cancellation Technology The patch-clamp technique remains the best method for examining ion channel physiology and membrane biophysics. Axon Instruments and pCLAMP software continue to push the envelope with new innovations with best-in-class systems and software. In this user meeting we learn how to design protocols easier, analyze data faster, and achieve better data quality. Speaker Jeffrey Tang, Senior Global Axon Electrophysiological Application Scientist, Molecular Devices

9:30 pm - 12:00 am, Hilton, Sapphire Reception and Quiet Room 9:30 pm - 12:00 am, Hilton, Indigo AE

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