Biophysical Society 2020 Annual Meeting

1302-Pos Board B370 USING ONSET-OF-BLOCK KINETIC ANALYSIS OF HERG1 CURRENT WITH A MARKOV MODEL TO IMPROVE IN SILICO PROARRHYTHMOGENIC RISK PREDICTION. Bogdan P. Amuzescu , Thomas Knott, Stefan A. Mann, Juliane Knuepling, Razvan Airini, Florin Bogdan Epureanu, Beatrice Mihaela Radu 1303-Pos Board B371 KV1.3 REGULATES THE DRIVING FORCE FOR CALCIUM ENTRY THROUGH P2X4 IN MICROGLIA. Hai M. Nguyen , Yi-Je Chen, Jacopo Di Lucente, Lee-Way Jin, Izumi Maezawa, Heike Wulff 1304-Pos Board B372 IDENTIFICATION OF SODIUM SENSITIVE SITE AND CHLORIDE SENSITIVE SITE ON THE C-TERMINUS OF RAT KCNT1 CHANNEL. Jie Xu, Xiao-Yun Zhao, Yan-Tian Lv, Yun Xu, Jing-Jing Wang, Qiong-Yao Tang, Zhe Zhang 1305-Pos Board B373 SLC7A5 ALTERS THE FUNCTIONAL INTERACTION BETWEEN KV1.2 AND KVΒ. Shawn M. Lamothe , Harley T. Kurata 1306-Pos Board B374 IDENTIFICATION OF EXTRACELLULAR PH-SENSING RESIDUES IN THE VOLTAGE-GATED PROTON CHANNEL HV1. Ashley L. Bennett, Guiliano Melki, I. Scott Ramsey Ion Channel Regulatory Mechanisms I (Boards B375 - B394) 1307-Pos Board B375 RELATIONSHIP BETWEEN AMINO ACID SEQUENCE MUTATIONS AND HUMAN DISEASES REVEALED BY PIEZO 1 ION CHANNEL STURCTURAL ANALYSIS. Zikai Zhou 1308-Pos Board B376 ACID-SENSING ION CHANNEL CURRENTS OF THE HYPOTHALAMUS ARE INCREASED BY HYDROGEN SULFIDE. Zhong Peng , Stephan Kellenberger 1309-Pos Board B377 MECHANISMS OF DOMINANCE OF MLC2B MUTATIONS IN GLIALCAM, A REGULATORY SUBUNIT OF THE CLC-2 CHLORIDE CHANNEL. Raul Estevez 1310-Pos Board B378 THE ROAD NOT TAKEN - LIPID/ION CONDUCTION PATHWAYS IN TMEM16 PROTEIN FAMILY. ZhiGuang Jia , Pengfei Liang, Trieu Le, Huanghe Yang, Jianhan Chen 1311-Pos Board B379 COMPUTATIONAL INSIGHTS INTO VOLTAGE DEPENDENCE OF POLY- AMINE BLOCK IN INWARDLY RECTIFYING K + CHANNELS. Michael Bründl , Xingyu Chen, Anna Stary-Weinzinger 1312-Pos Board B380 ATRIAL MYOCYTES MAINTAIN LOW [NA + ]I THROUGH SPECIALIZED NA + / K + ATPASE MICRODOMAIN. Humberto C. Joca, Libet Garber, Andrew Coleman, Liron Boyman, Mariusz Karbowski, Christopher W. Ward, W. Jonathan Lederer, Maura Greiser 1313-Pos Board B381 ENERGETICS OF CALMODULIN RECOGNITION OF A SKELETAL MUSCLE RYANODINE RECEPTOR SITE. Adina M. Kilpatrick , Ryan W. Mahling, Madeline A. Shea 1314-Pos Board B382 HOW DO KCNQ1 AND KCNE1 ASSEMBLE TO FORM THE SLOW- DE- LAYED-RECTIFIER (I KS ) CHANNELS IN ADULT VENTRICULAR MOCYTES (AVMS)? Sukhleen Kaur, Tytus Bernas, Zachary Wilson , Taylor Schultz, Min Jiang, Gea-Ny Tseng

1315-Pos Board B383 ARRHYTHMOGENIC VULNERABILITY IS ASSOCIATED WITH ALTERATIONS IN ION CHANNEL EXPRESSION, LOCALIZATION AND FUNCTION IN HY- PERTROPHIC CARDIOMYOPATHY. Henrietta Cserne-Szappanos, Danica W. Ito, Rose E. Dixon, Livia C. Hool 1316-Pos Board B384 EAG CHANNEL PAS DOMAIN BINDER INHIBITS CURRENTS FROM EAG CHANNELS AND DECREASES TUMOR GROWTH IN ZEBRAFISH XENO- GRAFT MODEL. Ze-Jun Wang, Pareesa Kamgar-Dayhoff, Purushottam B. Tiwari, Eric Glasgow, Tinatin I. Brelidze 1317-Pos Board B385 CONTROL OF SLC7A5 SENSITIVITY BY THE VOLTAGE-SENSING DOMAIN OF KV1 CHANNELS. Shawn M. Lamothe, Nazlee Sharmin, Victoria A. Baronas, Grace Silver, Yubin Hao, Harley T. Kurata 1318-Pos Board B386 THE ENERGY LANDSCAPE OF VOLTAGE SENSING IN CI-VSP. Rong Shen , Benoit Roux, Eduardo Perozo 1319-Pos Board B387 BOTH LOBES OF CALMODULIN BOUND TO KCA2.2 RESPOND TO CA 2+ . David Brent Halling , Ashley Philpo, Richard W. Aldrich 1320-Pos Board B388 CHARACTERISATION OF THE VERSATILE GATING BEHAVIOUR IN TALK-2 K 2P CHANNELS. Elena B. Riel , Björn Jürs, Jan Langer, Marianne Musin- szki, Sönke Cordeiro, Susanne Rinné, Niels Decher, Marcus Schewe, Thomas Baukrowitz 1321-Pos Board B389 SOLVING THE GATING MECHANISM OF THE MITOCHONDRIAL Β-BARREL METABOLITE CHANNEL VDAC. Maria Queralt-Martin , Van A. Ngo, Lucie A. Bergdoll, Jeff Abramson, David P. Hoogerheide, Tatiana K. Rostovt- seva, Sergey M. Bezrukov, Sergei Y. Noskov 1322-Pos Board B390 Travel Awardee AN ALLOSTERIC GATING MECHANISM OF TMEM16A CALCIUM-ACTIVAT- ED CHLORIDE CHANNEL. Son C. Le , Huanghe Yang 1323-Pos Board B391 NOVEL BIOPHYSICAL PROPERTIES OF MOLECULAR PERMEATION IN CALHM1 AND CONNEXIN CHANNELS. Pablo S. Gaete , Mauricio A. Lillo, William I. Lopez, Yu Liu, Andrew L. Harris, Jorge E. Contreras 1324-Pos Board B392 ANKYRIN-G MEDIATES TARGETING OF BOTH NA + AND KATP CHANNELS TO THE CARDIAC INTERCALATED DISC. Hua-Qian Yang , Marta Pérez- Hernández, Jose L. Sanchez-Alonso, Andriy Shevchuk, Julia Gorelik, Eli Rothenberg, Mario Delmar, William A. Coetzee 1325-Pos Board B393 GΒΓ ACTIVATES GIRK2 WITH LOW-MICROMOLAR AFFINITY WITH DIS- TINCT ACTIVATION PATTERN COMPARED TO GIRK1/2. Daniel Yakubo- vich, Uri Kahanovitch, Galit Tabak, Tal Keren Raifman, Vladimir Tse- makhovich, Debi Ranjan Tripathy, Carmen W. Dessauer, Joel A. Hirsch, Nathan Dascal 1326-Pos Board B394 LOV-NANO AS A NEW TOOL FOR THE REGULATION OF HCN CHANNELS BY BLUE LIGHT. Michal Laskowski, Andrea Saponaro, Alessandro Porro, Matias Zurbriggen, Gerhard Thiel, Anna Moroni

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