Biophysical Society 2020 Annual Meeting

1274-Pos Board B342 MODELING VAS DEFERENS SMOOTH MUSCLE ELECTROPHYSIOLOGY: ROLE OF ION CHANNELS IN GENERATING ELECTRICAL ACTIVITY.  Chitaranjan Mahapatra , Rohit Manchanda 1275-Pos Board B343 FUNCTIONAL ROLES OF CL - /HCO 3 - EXCHANGER IN THE SINOATRIAL NODE. Phung N. Thai, Lu Ren, Yankun Lyu, Valeriy Timofeyev, Hannah A. Ledford, Padmini Sirish, James Overton, Wilson Xu, Nipavan Chiamvimon- vat, Xiao-Dong Zhang 1276-Pos Board B344 EXPLORING THE EFFECTS OF 2.DEOXY-ATP ON SERCA 2A USING MUL- TISCALE MODELING. Kimberly J. McCabe , Sophia P. Hirakis, Abigail E. Teit- gen, Alexandre B. Duclos, Michael Regnier, Rommie E. Amaro, Andrew D. McCulloch Voltage-gated K Channels II (Boards B345 - B374) 1277-Pos Board B345 HALTING KCSA’S C-TYPE INACTIVATION GATING BY CONTROLLING WATER DIFFUSION BEHIND THE CHANNEL’S SELECTIVITY FILTER. D. Marien Cor- tes, Luis G. Cuello 1278-Pos Board B346 Travel Awardee RELATIVE HERG SUBUNIT ABUNDANCE MODIFIES I KR KINETICS AND MAGNITUDE DURING CARDIAC MATURATION. Chiamaka U. Ukachukwu 1279-Pos Board B347 A MOLECULAR MECHANISM FOR GATING POLARITY IN NON-DOMAIN- SWAPPED K V CHANNELS. Gustavo F. Contreras , Michael D. Clark, Rong Shen, Eduardo Perozo 1280-Pos Board B348 THE CARDIAC K V 7.1-KCNE1 CHANNEL ASSEMBLES AT ER-PM JUNCTIONS BEFORE TRANSLOCATED TO THE PLASMA MEMBRANE. Clara Serrano Novillo, Anna Oliveras, Núria Comes, Christian Soeller, Antonio Felipe 1281-Pos Board B349 TOLUENE-INDUCED INHIBITION OF SMOOTH MUSCLE BK CHANNELS AND MIDDLE CEREBRAL ARTERY CONSTRICTION. Kelsey C. North, Luiz Moreira, Alexandria Slayden, Anna N. Bukiya, Alex M. Dopico 1282-Pos Board B350 HCN DOMAIN IS NECESSARY FOR SURFACE EXPRESSION OF HCN CHAN- NELS. Zejun Wang , Ismary Blanco, Tinatin I. Brelidze 1283-Pos Board B351 BK CHANNEL GAMMA3 SUBUNIT (LRRC55) KNOCK-OUT MICE SHOW ATAXIA-LIKE PHENOTYPE. Xin Guan, Jiusheng Yan 1284-Pos Board B352 BLOCK OF THE CARDIAC POTASSIUM CHANNEL HERG BY CATIONS. Jer- emy Adrian, Jacky Ng, Huzaifa Khawaja, Zahra Asadollahi, Alan Miller 1285-Pos Board B353 DYNAMIC CHARACTERIZATION OF KCNQ1 AND ITS REGULATORY SUB- UNITS REVEALED BY FLUORESCENCE FLUCTUATION TECHNIQUES. Giulia Tedeschi , Lorenzo Scipioni, Geoffrey Abbott, Michelle A. Digman 1286-Pos Board B354 CHOOSING THE CORRECT STOICHIOMETRY FROM SINGLE SUBUNIT COUNTING DATA. Lena Moeller, Alain J. Labro, Dirk J. Snyders, Rikard Blunck 1287-Pos Board B355 INHIBITION OF THE VOLTAGE-GATED POTASSIUM CHANNEL KV2.1 BY RY785, A KV2-SELECTIVE SMALL MOLECULE. Matthew J. Marquis , Mi- chelle Nguyen, Jon T. Sack

1288-Pos Board B356 OBSERVATION OF MULTIPLE POTASSIUM CHANNEL CLOSED STATE STRUC- TURES BY VOLTAGE CLAMP SPECTROSCOPY. Parashar Thapa, Sebastian Fletcher-Taylor, Rebecka J. Sepela, Vladimir Yarov-Yarovoy, Jon T. Sack , Bruce E. Cohen 1289-Pos Board B357 K V 1.3 INTERACTS WITH A CALMODULIN-BINDING TETRALEUCINE MOTIF OF KCNE4. Daniel Sastre , Laura Sole Codina, Sara R. Roig, Gregorio Fernandez-Ballester, Michael M. Tamkun, Antonio Felipe 1290-Pos Board B358 KCNQ1 DDG CALCULATIONS AND CORRELATION TO EXPERIMENTAL DATA. Kathryn R. Brewer , Hui Huang, Georg Kuenze, Jens Meiler, Charles Travel Awardee MEASURING INTRINSIC LIGAND DYNAMICS OF HERG POTASSIUM CHAN- NELS USING THE UNNATURAL AMINO ACID L-ANAP AND TM-FRET.  Sara J. Codding , Matt C. Trudeau 1292-Pos Board B360 CHARACTERIZATION OF A NOVEL HIGH-SELECTIVITY KV1.3 INHIBITOR PEPTIDE. Agota Csoti, Lourival D. Possani, Gyorgy Panyi 1293-Pos Board B361 BENEFICIAL EFFECT OF CITRUS FLAVONOID - NARINGENIN ON EN- DOTHELIAL CELLS BY ACTIVATION OF MITOCHONDRIAL POTASSIUM CHANNELS. Rafal P. Kampa , Aleksandra Sęk, Anna Kicińska, Jan Daniluk, Wieslawa Jarmuszkiewicz, Adam Szewczyk, Piotr Bednarczyk 1294-Pos Board B362 CHARACTERIZATION OF DIRECT CYCLODEXTRIN EFFECTS ON VOLTAGE- GATED POTASSIUM CHANNELS. Florina Zakany, Tamas Kovacs, Tamas Sohajda, Lajos Szente, Peter Nagy, Gyorgy Panyi, Zoltan Varga 1295-Pos Board B363 GATING MECHANISMS OF CARDIAC AND NEURONAL KCNQ POTASSIUM CHANNELS. Nien-Du Yang , Alex Dou, Po Wei Kang, Panpan Hou, Kelli McFarland White, Jingyi Shi, Jianmin Cui 1296-Pos Board B364 PROTEIN-PROTEIN INTERACTIONS OF KCNQ1 AND KCNE1 OBSERVED VIA SDSL-EPR LINE SHAPE ANALYSIS. Rebecca Stowe , Gunjan Dixit, Indra D. Sahu, Gary A. Lorigan 1297-Pos Board B365 COMPARING ENSEMBLE VERSUS SINGLE CELL RECORDINGS OF VOLTAGE- GATED CHANNELS WITH A MICROFLUIDICS BASED AUTOMATED PATCH CLAMP. Ali Yehia , Alexandra Stevens 1298-Pos Board B366 REVERSIBLE BLOCK OF BK CHANNELS BY PIPERINE. Aravind S. Kshatri, Teresa Giraldez 1299-Pos Board B367 RESIN-ACID DERIVATIVES OPEN THE HK V 7.2/7.3 CHANNEL AND HAVE AN- TIEPILEPTIC EFFECTS IN A ZEBRAFISH LARVAE MODEL. Nina E. Ottosson , Malin Silverå Ejneby, Michelle Nilsson, Urban Karlsson, Melanie Schupp, Xiongyu Wu, Peter Konradsson, Fredrik Elinder 1300-Pos Board B368 ION BEHAVIOUR IN THE HCN1 CHANNEL SELECTIVITY FILTER. Sajjad Ahrari, Nazzareno D’Avanzo 1301-Pos Board B369 JOURNEY FROM THE PORE CAVITY TO THE SELECTIVITY FILTER IN K V 1.2: HOW K + DOES IT, AND NA + CAN’T QUITE. Alisher M. Kariev, Michael E. Green R. Sanders 1291-Pos Board B359

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