Biophysical Society 2020 Annual Meeting

Muscle Regulation (Boards B330 - B344)

1250-Pos Board B318 SERCA STIMULATION TRIGGERS ARRHYTHMOGENIC CA 2+ EVENTS IN MOUSE CARDIOMYOCYTES HARBORING THE RYR2 R420Q+/- MUTATION.  Ruben Jose Lopez Dicuru , Miguel Fernandez-Tenorio, Radoslav Janicek, Ana M. Gomez, Ernst Niggli 1251-Pos Board B319 IMPROVEMENTS OF ER-CA 2+ BASED HIGH-THROUGHPUT SCREENING METHOD FOR SEARCHING NOVEL RYR2 INHIBITORS. Masatoshi Ito , Nagomi Kurebayashi, Takashi Murayama, Mai Tamura, Junji Suzuki, kazunori Kanemaru, Masamitsu Iino, Takashi Sakurai 1252-Pos Board B320 EFFECTS OF RYR2 INHIBITORS ON CA 2+ SIGNALS IN HEALTHY AND DISEASED CARDIAC CELLS. Nagomi Kurebayashi , Takashi Murayama, Masato Konishi, Shuichi Mori, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Haruo Ogawa, Sachio Morimoto, Takashi Sakurai 1253-Pos Board B321 DWORF DIRECTLY REGULATES CARDIAC SERCA FUNCTION. Elisa Bovo , Christopher S. Hoover, M’Lynn Fisher, Jonathan Jeske, Roman Nikolaien- ko, Daniel Kahn, Seth L. Robia, Howard S. Young, Aleksey V. Zima 1254-Pos Board B322 PROBING THE RYR2 CA 2+ AND CAFFEINE BINDING SITES BY MUTAGEN- ESIS IN HUMAN STEM-CELL DERIVED CARDIOMYOCYTES BY CRISPR/ CAS9 GENE EDITING. Yanli Xia , Xiaohua Zhang, Naohiro Yamaguchi, Martin Morad 1255-Pos Board B323 ANALYSIS OF LOCAL CALCIUM FLUCTUATIONS IN CARDIAC MYO- CYTES. Cherrie H. Kong , Mark B. Cannell 1256-Pos Board B324 CPVT-ASSOCIATED MUTATION P.G357S-RYR2 PROMOTES A GAIN OF FUNCTION IN PATIENT-SPECIFIC INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES (IPS-CM). David Carreras , Rebecca Martinez-Moreno, Elisabet Selga, Ramon Brugada, Fabiana S. Scornik, Guillermo J. Perez 1257-Pos Board B325 Travel Awardee HYPERACTIVITY OF RYR2 IN CARDIAC DISEASE IS EXACERBATED BY CAL- CIUM LEAK-INDUCED MITOCHONDRIAL ROS. Shanna Hamilton , Rad- mila Terentyeva, Jiaoni Li, Andrei Stepanov, Ingrid M. Bonilla, Bjorn C. Knollmann, Przemyslaw Radwanski, Sandor Gyorke, Andriy E. Belevych, Dmitry Terentyev 1258-Pos Board B326 EFFECTS OF ULTRASTRUCTURAL REMODELING ON CALCIUM SIGNALING AND ELECTROPHYSIOLOGY IN A THREE-DIMENSIONAL MODEL OF THE HUMAN ATRIAL MYOCYTE. Xianwei Zhang , Haibo Ni, Stefano Morotti, William E. Louch, Andrew G. Edwards, Daisuke Sato, Eleonora Grandi 1259-Pos Board B327 ELEMENTARY INTRACELLULAR CALCIUM SIGNALS ARE INITIATED BY A PHASE TRANSITION OF CALCIUM RELEASE CHANNELS IN A METASTABLE STATE. Guillermo Veron , Anna Maltsev, Michael D. Stern, Victor A. Maltsev 1260-Pos Board B328 NOVEL MITOCHONDRIAL CA 2+ UPTAKE ENHANCERS FOR THE TREAT- MENT OF CARDIAC ARRHYTHMIA. Paulina Sander , Daniela M. Arduino, Maria K. Schweitzer, Fabiola Wilting, Thomas Gudermann, Fabiana Perocchi, Johann Schredelseker 1261-Pos Board B329 PHARMACOLOGICAL MODULATION OF MITOCHONDRIA CA 2+ EXERTS DIVERGENT EFFECTS ON ARRHYTHMOGENIC CALCIUMWAVES IN CA 2+ - DEPENDENT AND METABOLIC CARDIAC DISEASE. Brian Tow, Anna-Beth Loper, Dongyu Wang, Bjorn C. Knollmann, Sandor Gyorke, Bin Liu

M O N D A Y

1262-Pos Board B330 RIBONUCLEOTIDE REDUCTASE IS ESSENTIAL IN ADULT CARDIOMYO- CYTES. Kristina B. Kooiker , Djelli Berisha, Amy Martinson, Joelle Tudor, Jeremy Freeman, Claire Branley, Farid Moussavi-Harami 1263-Pos Board B331 CARDIAC PALMITOME SHEDS NEW LIGHT ON THE STRUCTURAL AND FUNCTIONAL ROLES OF S-PALMITOYLATION IN CARDIAC MYO- CYTES. Madeleine Miles , Nicholas Rodriguez, Min Jiang, Jane E. Tomaszewski, Isabelle Deschenes, Gea-Ny Tseng 1264-Pos Board B332 HYPERTROPHIC CARDIOMYOPATHY: PROLONGED TWITCH, CALCIUM TRANSIENTS AND ACTION POTENTIALS IN HUMAN STEM CELL-DERIVED CARDIOMYOCYTES WITH Β-MYOSIN MUTATION R723G. Natalie Weber , Tim Holler, JoachimMeißner, Judith Montag, Martin Fischer, Jeanne de la Roche, Stefan Thiemann, Neele Peschel, Anne Kathrin Mayer, Kristin Schwanke, Birgit Piep, Ulrich Martin, Robert Zweigerdt, Theresia Kraft 1265-Pos Board B333 THE MECHANICAL PROPERTIES OF A UTROPHIN CONSTRUCT ENCODING THE TANDEM CH ACTIN BINDING DOMAIN THROUGH SPECTRIN REPEAT 3 IS ALTERED BY THE CELL EXPRESSION SYSTEM THROUGH POST- TRANSLATIONAL MODIFICATIONS. Maria Paz Ramirez Lopez , Sivaraman Rajaganapathy, Wendy R. Gordon, Murti V. Salapaka, James M. Ervasti 1266-Pos Board B334 ELUCIDATING THE ROLE OF PHOSPHORYLATED REGULATORY LIGHT CHAIN PROTEINS (RLC) DURING HEART FAILURE PROGRESSION.  Kasturi Markandran 1267-Pos Board B335 CALCIUM REGULATES AVERAGE TIME AND NOT VELOCITY A THIN FILAMENT MOVES. Henry G. Zot , Javier E. Hasbun, Prescott B. Chase, J. Renato D. Pinto 1268-Pos Board B336 ESSENTIAL ROLE OF SEPTIN 7 IN SKELETAL MUSCLE STRUCTURE AND FUNCTION. Laszlo Csernoch , Mónika Gönczi, Zsolt Ráduly, László Szabó, Nóra Dobrosi, Péter Szentesi, Beatrix Dienes 1269-Pos Board B337 STUDY BIOPHYSICS OF ESOPHAGEAL TRANSPORT BY COMBINING SIMULATION, MODELING AND BIO-MECHANICAL ANALYSIS BASED ON IN-VIVO DATA. Wenjun Kou , Shashank Acharya, Sourav Halder, Neelesh Patankar, John Pandolfino 1270-Pos Board B338 THE GLU-RICH C-TERMINAL EXTENSION OF INSECT TROPONIN T IS AN ESSENTIAL STRUCTURE CRITICAL TO EMBRYONIC DEVELOPMENT.  Alyson Sujkowski , Tianxin Cao, J.-P. Jin 1271-Pos Board B339 K ATP CHANNELS IN ZEBRAFISH CARDIOVASCULAR SYSTEM: A MODEL TO STUDY CANTÚ SYNDROME. Soma S. Singareddy , Helen I. Roessler, Conor McClenaghan, Rob C. Tryon, Gijs van Haaften, Colin G. Nichols 1272-Pos Board B340 UNIVERSAL INVERSE SQUARE RELATIONSHIP BETWEEN HEART RATE VARIABILITY AND HEART RATE. Anna Maltsev , Oliver J. Monfredi, Victor Board B341 TISSUE MECHANISMS OF ADULT ZEBRAFISH VENTRICULAR ECG PAT- TERNS UNDER BASELINE AND OXIDATIVE STRESS CONDITION. Yali Zhao, Nicholas James, Ashraf Beshay, Eileen Chang, Thao P. Nguyen A. Maltsev 1273-Pos

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