Biophysical Society 2020 Annual Meeting

Mechanosensation I (Boards B294 - B312) 1226-Pos Board B294 CHARACTERIZING THE EXPRESSION AND FUNCTION OF THE MECHANO- SENSITIVE PIEZO1 CHANNEL IN THE HEART. Fan Jiang 1227-Pos Board B295 DIFFERENT MECHANICAL RESPONSES TO SUBSTRATE STIFFNESS BE- TWEEN CANCER CELLS AND NORMAL CELLS. Fang Tian , Tsung-Cheng Lin, Liang Wang, Sidong Chen, Caishan Yan, Pak Man Yiu, Ophelia K.C. Tsui, Jun Chu, Ching-Hwa Kiang, Hyokeun Park 1228-Pos Board B296 CORYNEBACTERIAL “FORCE-FROM-LIPIDS” MECHANOSENSATION FOR MSG PRODUCTION. Yoshitaka Nakayama , Ken-ichi Hashimoto, Hisashi Kawasaki, Boris Martinac 1229-Pos Board B297 QUANTITATIVE NANO-PLATFORMS FOR INTERROGATION OF CURVATURE SENSITIVE PROTEINS. Ching-Ting Tsai 1230-Pos Board B298 STRUCTURE AND MECHANOGATING OF THE MAMMALIAN TACTILE CHANNEL PIEZO2. Wenhao Liu 1231-Pos Board B299 CADHERIN COMPLEXES ARE COMBINATORIAL MECHANO-SWITCHES THAT DIFFERENTIALLY REGULATE CELL MECHANICS. Vinh H. Vu, Zainab Rahil, Brendan G. Sullivan , Deborah E. Leckband 1232-Pos Board B300 SURVIVIN IS A MECHANOSENSITIVE REGULATOR OF VASCULAR SMOOTH MUSCLE CELL PROLIFERATION.  John C. Biber , Yongho Bae 1233-Pos Board B301 QUANTIFYING THE EFFECT OF FATTY ACIDS ON THE ELASTICITY OF MODEL MEMBRANES. Miranda L. Jacobs , Neha P. Kamat 1234-Pos Board B302 THE INFLUENCE OF SUBSTRATE ELASTICITY ON CELL ADHESION MECHA- NISMS. Zbigniew Baster , Zenon Rajfur 1235-Pos Board B303 Travel Awardee EXPLORING THE STRUCTURAL ELEMENTS RESPONSIBLE FOR CIS -HO- MODIMERIZATION OF INNER EAR CADHERIN-23.  Joseph C. Sudar , Jasan- vir Sandhu, Pedro De-la-Torre, Deepanshu Choudhary, Marissa Boyer, Florencia Velez-Cortes, Jeshua K. Avila-Estrada, Collin Nisler, Michael L. Leake, Marcos M. Sotomayor 1236-Pos Board B304 CONTRACTILITY AUTOREGULATION IN CARDIOMYOCYTES EMERGES FROMMECHANOSENSOR GEOMETRY AND MECHANO-CHEMO-TRANS- DUCTION. Leighton T. Izu , Rafael Shimkunas, Zhong Jian, Tamas Banyasz, Ye Chen-Izu 1237-Pos Board B305 Travel Awardee MSCS IS A CRITICAL COMPONENT FOR OSMOTIC SURVIVAL OF VIBRIO CHOLERAE. Madolyn Britt , Kristen Ramsey, Joseph Maramba, Blake Ushijima, Elissa Moller, Andriy Anishkin, Claudia Hase, Sergei I. Sukharev 1238-Pos Board B306 EXPLORING THE FUNCTIONAL IMPLICATIONS OF THE STRUCTURAL RELA- TIONSHIP BETWEEN TMC1 AND TMEM16 PROTEINS. Angela Ballesteros , Kenton Swartz

1239-Pos Board B307 MECHANICAL FORCES ALTER ENDOTHELIN-1 SIGNALING: COMPARA- TIVE OVINE MODELS OF CONGENITAL HEART DISEASE. Antoni Garcia- Herreros , Rebecca J. Kameny, Terry Zhu, Jason Boehme, Gary Raff, Juan C. Lasheras, Stephen M. Black, Emin Maltepe, Sanjeev A. Datar, Jeffrey R. Fineman 1240-Pos Board B308 ACTIVE FORCES ON CELL-CELL CONTACTS ENABLE EFFICIENT IMMUNE DISCRIMINATION. Shenshen Wang 1241-Pos Board B309 A FRET-BASED SENSOR FOR PROBING FORCES EXERTED BY SINGLE T CELL RECEPTORS ON THEIR LIGANDS. Lukas Schrangl , Janett Goehring, Florian Kellner, Johannes B. Huppa, Gerhard J. Schütz 1242-Pos Board B310 CELL GEOMETRY MODULATES THE ACTIVATION OF FIBROBLASTS IN 3D TUMOR MICROENVIRONMENTS. Saradha Venkatachalapathy , D.S. Jokhun, G.V. Shivashankar 1243-Pos Board B311 Travel Awardee YAP ACTIVITY DIRECTLY SCALES WITH NUCLEAR DEFORMATION AND LAMIN A DISTRIBUTION. Newsha Koushki , Allen J Ehrlicher 1244-Pos Board B312 MECHANICAL CHARACTERIZATION OF EXTRACELLULAR VESICLES DE- RIVED FROM IMMORTALIZED ADIPOSE STROMAL CELLS.  Melissa C. Piontek , Sourav Maity, Linda A. Brouwer, Martin C. Harmsen, Wouter H. Roos Intracellular Calcium Channels and Calcium Sparks and Waves I (Boards B313 - B329) 1245-Pos Board B313 CHARACTERIZATION OF RYR2 MUTATIONS LOCATED AT THE CAFFEINE AND FKBP BINDING SITES IN HIPSC-CMS.  Jose Carlos Fernandez Morales , Xiaohua Zhang, Yanli Xia, Naohiro Yamaguchi, Martin Morad 1246-Pos Board B314 INCREASED SR CALCIUM LEAK IS PROMOTED BY O-GLCNACYLATION OF CAMKII IN DIABETES AND HYPERGLYCEMIA. Anna Fasoli , Christopher Y. Ko, Bence Hegyi, Wenjun Pan, Benjamin W. Van, Erin Y. Shen, Sonya Baidar, Julie Bossuyt, Donald M. Bers 1247-Pos Board B315 ROLE OF SK CURRENT RECTIFICATION IN SHAPING ACTION POTENTIAL OF VENTRICULAR CARDIOMYOCYTES. Peter Bronk , Tae Yun Kim, Iuliia Polina, Shanna Hamilton, Radmila Terentieva, Karim Roder, Gideon Koren, Dmi- try A. Terentyev, Bum-Rak Choi 1248-Pos Board B316 SORAFENIB SUPPRESSES BASAL SPONTANEOUS BEATING OF RABBIT SINOATRIAL NODE CELLS (SANC) THROUGH INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 (VEGFR1).  Tatiana M. Vinogradova , Kirill Tarasov, Yelena Tarasova, Edward G. Lakatta 1249-Pos Board B317 A NOVEL IN VITRO MODEL USING ORGANOTYPIC CARDIAC SLICES REVEALS TRANSMURAL HETEROGENEITY IN ARRHYTHMOGENIC CA 2+ EVENTS AFTER CARDIAC INJURY. Eef Dries , Ifigeneia Bardi, Fotios Pitoulis, Raquel Nunez-Toldra, Warrapong Kit-Anan, Cesare M. Terracciano

M O N D A Y

85