Biophysical Society 2020 Annual Meeting

1575-Plat 8:45 am MEMBRANE SOLUBILIZATION BY DIISOBUTYLENE-MALEIC ACID (DIBMA) COPOLYMERS AND CHARACTERIZATION OF THE RESULTING NATIVE NANODISCS.  Adrian H. Kopf , Barend O.W. Elenbaas, Martijn C. Kooren- gevel, Cornelis A. van Walree, J. Antoinette Killian 1576-Plat 9:00 am TRANSIENT ELECTRODEFORMATION OF GIANT UNILAMELLAR VESICLES (GUVS) TO PROBE MEMBRANE VISCOSITY.  Hammad A. Faizi , Rumiana Dimova, Petia M. Vlahovska 1577-Plat 9:15 am CURVED LIPID INTERFACES STUDIED WITH GRAZING INCIDENT SANS.  Karolina Mothander , Tommy Nylander, Adrian Rennie 1578-Plat 9:30 am THE STRUCTURAL ORIGIN OF CHOLESTEROL INDUCED PHOSPHOINOSIT- IDE CLUSTERING.  Kyungreem Han, Anne-Marie Bryant, Richard W. Pastor, Arne Gericke 1579-Plat 9:45 am COUPLING BETWEEN CYTOPLASMIC PROTEIN PHASE SEPARATION AND CHOLESTEROL-RICH DOMAINS IN THE PLASMA MEMBRANE FACILITATES T CELL ACTIVATION.  Hongyin Wang , Barbara Diaz-Rohrer, Kandice R. Levental, Jonathon A. Ditlev, Michael K. Rosen, Ilya Levental 1580-Plat 10:00 am USING AFM-NANO IR SPECTROSCOPY AND SUM-FREQUENCY GENERA- TION (SFG) VIBRATIONAL SPECTROSCOPY TO INVESTIGATE SICKLE CELL DISEASE.  Alexander P. Fellows , Mike T.L. Casford, John N. Brewin, David C. Rees, Paul B. Davies, John S. Gibson Platform Protein-Small Molecule Interactions 8:15 am - 10:15 am, Room 24ABC Co-Chairs Karan Kapoor, University of Illinois at Urbana-Champaign Matthias Preller, Medizinische Hochschule Hannover, Germany 1581-Plat 8:15 am MULTISTAGE INHIBITION OF THE MYOSIN XIV-BASED INVASION MOTOR IN THE MALARIA PARASITE AND RELATED PATHOGENS. Matthias Preller , Janna Ehlert 1582-Plat 8:30 am COMPUTING POSES OF LIGANDS BOUND TO PROTEINS USING MELD ACCELERATED MOLECULAR DYNAMICS.  Cong Liu , Emiliano Brini, Alberto Perez, Ken A. Dill 1583-Plat 8:45 am CHARACTERIZING EVOLUTION OF BINDING SITES IN P-GLYCOPROTEIN THROUGH EXTENDED-ENSEMBLE DOCKING.  Karan Kapoor , Sundarapan- dian Thangapandian, Emad Tajkhorshid 1584-Plat 9:00 am EXPLORING THE BINDING POTENCY AND SPECIFICITY OF SMALL MOL- ECULES AGAINST THE TRANSMEMBRANE AMYLOID PRECURSOR PROTEIN FRAGMENT, C99. Manuel Castro 1585-Plat 9:15 am Travel Awardee STRUCTURAL BASIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) TRANSPORT BY SERUM ALBUMIN. Mateusz P. Czub , Katarzyna B. Handing, Barat S. Venkataramany, Ivan G. Shabalin, Wladek Minor 1586-Plat 9:30 am USING REVERSE MICELLES TO EXTEND THE DETECTION LIMIT OF WEAK LIGAND-PROTEIN INTERACTIONS.  Brian Fuglestad, Nicole E. Kerstetter , Sabrina Bed́ard, A. Joshua Wand

1587-Plat 9:45 am FLUORESCENCE-BASED BIOSENSOR TO QUANTIFY SMALL MOLECULE BINDING KINETICS WITH TARGET SPATIAL RESOLUTION.  Joanna Deek, Thomas Weber, Ulrich Rant 1588-Plat 10:00 am STRUCTURALLY-DIVERSE NON-COVALENT ALLOSTERIC KRAS INHIBITORS  Cynthia Pagba , Amit K. Gupta, Michael McCarthy, Yong Zhou, Alemayehu A. Gorfe Platform Ion Channels, Pharmacology, and Disease 8:15 am - 10:15 am, Room 25ABC Co-Chairs Mercedes Alfonso-Prieto, University of Barcelona, Spain Paul DeCaen, Northwestern University 1589-Plat 8:15 am MOLECULAR REGULATION OF POLYCYSTIN TRP CHANNELS.  Thuy Vien, Jinliang Wang, Leo C. Ng, Erhu Cao, Paul G. DeCaen 1590-Plat 8:30 am MODULATION OF GIRK CHANNELS BY PROTEIN KINASE C AND ITS ROLE IN ATRIAL FIBRILLATION.  Kirin Gada , Aishwarya Chandrashekar, Yu Xu, Takeharu Kawano, Leigh D. Plant, Diomedes E. Logothetis 1591-Plat 8:45 am Travel Awardee MOLECULAR MECHANISM OF MODULATION OF THE TMEM16A CHAN- NEL BY ANTHRACENE-9-CARBOXYLIC ACID: IMPLICATIONS FOR CHANNEL GATING.  Ria Dinsdale , Angela Russell, Phillip J. Stansfeld, Paolo Tammaro 1592-Plat 9:00 am AN ALL-OPTICAL ELECTROPHYSIOLOGY SCREENING PLATFORM TO IDEN- TIFY NAV CHANNEL MODULATORS AS PAIN THERAPEUTICS.  Hongkang Zhang , Kit Werley, Pin Liu, Gabriel Borja, Steven Nagle, Gra- ham Dempsey, Owen McManus 1593-Plat 9:15 am DEMONSTRATION OF A PREDICTIVE MULTISCALE MODEL FOR DRUG-IN- DUCED ARRHYTHMOGENIC RISK.  Kevin R. DeMarco , Pei-Chi Yang, Parya Aghasafari, John R.D. Dawson, Slava Bekker, Sergei Y. Noskov, Vladimir Yarov-Yarovoy, Igor Vorobyov, Colleen E. Clancy 1594-Plat 9:30 am PHOTOMODULATION OF INHIBITORY NEUROTRANSMISSION. INSIGHTS FROMMOLECULAR MODELING.  Alba Nin-Hill, Galyna Maleeva, Alexan- dre Gomila-Juaneda, Daniel Wutz, Karin Rustler, Antoni Bautista-Barrufet, Xavier Rovira, Miquel Bosch, Petra Scholze, Franck Peiretti, Carme Rovira, Burkhard König, Pau Gorostiza, Piotr Bregestovski, Mercedes Alfonso Prieto 9,10 1595- Plat 9:45 am FLUORESCENCE MICROSCOPY TOOLS TO STUDY THE HETEROMERIC AS- SEMBLY OF AN ION CHANNEL.  Gerardo Abbandonato , Alessandro Porro, Lorenzo Brocca, Anna Moroni 1596-Plat 10:00 am TARGETED DEUBIQUITINATION AS A GENERAL STRATEGY TO RESCUE TRAFFICKING-DEFICIENT ION CHANNELOPATHIES.  Scott A. Kanner , Zun- aira Shuja, Papiya Choudhury, Ananya Jain, Henry M. Colecraft

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