Biophysical Society 2020 Annual Meeting

Platform Cardiac Muscle Regulation 8:15 am - 10:15 am, Room 30ABC

1606-Plat 8:30 am PKA-DEPENDENT PHOSPHORYLATION OF MITOCHONDRIAL SK2 CHAN- NELS REGULATES MITOCHONDRIAL CALCIUM UPTAKE IN VENTRICULAR CARDIOMYOCYTES.  Shanna Hamilton , Radmila Terentyeva, Benjamin Martin, Karim Roder, Gideon Koren, Richard T. Clements, Dmitry Teren- tyev 1607-Plat 8:45 am BETA-ADRENERGIC SIGNALING IN ISOLATED CARDIOMYOCYTES PROPA- GATES SPATIALLY OVER TIME.  Thomas R. Shannon , Dan J. Bare, Shayan Raofi, Kenneth S. Ginsburg, Donald M. Bers 1608-Plat 9:00 am MITOCHONDRIAL NCX INHIBITION REDUCES OXIDATIVE STRESS AND SR CALCIUM LEAK IN DIABETIC MYOCYTES.  Sathya Velmurugan , Amanda Hoskins, Sarah Fleischer, Florin Despa, Sanda I. Despa 1609-Plat 9:15 am SODIUM-CALCIUM EXCHANGER (NCX1) IS ESSENTIAL FOR ATRIOVENTRIC- ULAR NODE AUTOMATICITY AND CONDUCTION, AS REVEALED THROUGH ATRIAL-SPECIFIC KNOCKOUT OF NCX1.  Adina Hazan , Rui Zhang, Sabine Lotteau, Yen-Nien Lin, Devina Gonzalez, Kenneth D. Philipson, Michela Ottolia, Joshua I. Goldhaber 1610-Plat 9:30 am STIM1 MAINTAINS STABLE PERIPHERAL COUPLING IN FULLY DIFFERENTI- ATED CONTRACTILE VASCULAR SMOOTH MUSCLE CELLS INDEPENDENTLY OF CA 2+ STORE DEPLETION.  Vivek Krishnan , Sher Ali, Pratish Thakore, Martin Johnson, Evan Yamasaki, Mohamed Trebak, Scott Earley 1611-Plat 9:45 am MEMBRANE DEPOLARIZATION IS ESSENTIAL FOR TRIGGERING CA 2+ INFLUX INTO ADRENAL CHROMAFFIN CELLS EXPOSED TO NANOSECOND ELECTRIC PULSES.  Lisha Yang , Sophia Pierce, Gale L. Craviso, Normand Leblanc 1612-Plat 10:00 am INTRINSICALLY DISORDERED HS ASSOCIATED PROTEIN X-1 (HAX-1) ALTERS THE STRUCTURE OF THE SERCA2A - PHOSPHOLAMBAN REGULATORY COMPLEX. Michael P. Dalton , Erik K. Larsen, Elisa Bovo, Aleksey V. Zima, Gianluigi Veglia, Seth L. Robia Subgroup Chairs Meeting 9:00 am - 10:30 am, Room 32A Career Development Center Workshop Looking Beyond Academia: Identifying Your Career Options Using MyIDP, LinkedIn & More 9:30 am - 10:30 am, Room 26A Not sure where your professional future lies or how to approach the pro- cess in an organized and strategic manner? This presentation provides a framework and resources for moving forwardwith confidence towards the next step in your professional future. In addition, it will provide specific ex- amples of how to build out your knowledge of a new potential career field and forge valuable connections that can facilitate a successful transition.

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Co-Chairs Osha Roopnarine, University of Minnesota Medical School Danuta Szczesna-Cordary, University of Miami 1597-Plat 8:15 am ACTIN-BINDING COMPOUNDS THAT AFFECT THE ATP-INDUCED DISSO- CIATION OF THE ACTIN-MYOSIN COMPLEX.  Osha Roopnarine , David D. Thomas 1598-Plat 8:30 am A MOLECULAR DYNAMICS STUDY OF SMALL MOLECULES BOUND TO A FULL ATOMISTIC MODEL OF CARDIAC THIN FILAMENT AS A METHOD TO IDENTIFY POSSIBLE TREATMENTS FOR GENETIC CARDIOMYOPATHIES.  Elango Munusamy , Steven D. Schwartz, Jil C. Tardiff 1599-Plat 8:45 am FLEXIBLE SUBSTRATE IS KEY TO APPROPRIATE CONTRACTILE BEHAVIOUR OF HIPSC DERIVED CARDIOMYOCYTES.  Eline Huethorst , Francis L. Bur- ton, Nikolaj Gadegaard, Godfrey L. Smith 1600-Plat 9:00 am TWO SMALL MOLECULE INHIBITORS OF MYOSIN DECREASE FORCE AND INCREASE RATES OF RELAXATION IN DEMEMBRANATED RAT LEFT VEN- TRICULAR TISSUE.  Kristina B. Kooiker , Qing-Fen Gan, Ming Yu, Yuanhua Cheng, Na Sa, Min Zhong, TimMcMillen, Farid Moussavi-Harami, Michael Regnier 1601-Plat 9:15 am Travel Awardee MOLECULAR MECHANISMS AND THERAPEUTIC APPROACHES OF MYOFILAMENT GLYCATION AS A RESULT OF DIABETES. Maria Papadaki , Theerachat Kampaengsri, Raiza Bonomo, Chelsea White, Virginie Aubert, Greg Aubert, Stuart Campbell, Jonathan A. Kirk 1602-Plat 9:30 am Travel Awardee STOPPED-FLOW CALCIUM KINETICS OF HYPERTROPHIC CARDIOMYOPA- THY-ASSOCIATED TROPONIN T MUTATIONS. MatthewM. Klass , Grace Heffernon, Garrett Hauck, Sarah Lehman, Jonathan P. Davis, Jil C. Tardiff 1603-Plat 9:45 am DISTINCT MUTATION-SPECIFIC EFFECTS ON THIN FILAMENT ACTIVATION LEAD TO DILATED CARDIOMYOPATHY PHENOTYPE IN CELLS.  Samantha K. Barrick , Lina Greenberg, Michael J. Greenberg 1604-Plat 10:00 am Travel Awardee DELETION OF THE N-TERMINUS OF MYOSIN ESSENTIAL LIGHT CHAIN (N-ELC) IN THE BACKGROUND OF HCM-A57G MUTATION IN DOUBLE MUTANT MICE RESCUES HYPERCONTRACTILE MYOSIN PHENOTYPE.  Yoel H. Sitbon , Katarzyna Kazmierczak, Melanie Veerasammy, Jingsheng Liang, Danuta Szczesna-Cordary Platform Calcium Signaling 8:15 am - 10:15 am, Room 31ABC Co-Chairs

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Exhibitor Presentation Sophion Bioscience A/S 9:30 am - 11:00 am, Room 33A

Christopher Weber, University of Chicago Lisha Yang, University of Nevada, Reno 1605-Plat 8:15 am

TARGETING CA 2+ FLUXES IN ATRIAL FIBRILLATION. Wenli Dai, Stefano Morotti, Ivan Moskowitz, Eleonora Grandi, Christopher Weber

Characterization of the Rapidly Desensitizing α7 Nicotinic Acetylcholine Receptor on the Qube, NaV1.1 Assays on Automated Electrophysiology Platforms and Developing NMDA Assays on the Qube System Successful ion channel drug discovery requires the integration of multiple technologies and workflows. Sophion Bioscience is a leader in automated patch clamp technology, providingmediumtohigh throughput, automated patch clamp to the pharmaceutical industry and universities. The QPatch and Qube are fully automated patch clamp systems, executing simultane-

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