Biophysical Society 2020 Annual Meeting

Platform Optical Microscopy and Superresolution Imaging III 10:45 am - 12:45 pm, Ballroom 20BC Co-Chairs Anthony Fernandez, University of Southern California Madoka Suzuki, Osaka University, Japan 1613-Plat 10:45 am DUAL-FUNCTIONALIZED FLUORESCENT NANODIAMOND AS NANO- HEATER AND NANOTHERMOMETER IN CELLS.  Chongxia Zhong , Shingo Sotoma, Taras Plakhotnik, James Chen Yong Kah, Yoshie Harada, Madoka Suzuki 1614-Plat 11:00 am Travel Awardee MULTI-PARAMETER FLUORESCENCE LIFETIME IMAGING MICROSCOPY (FLIM) FOR IMAGING METABOLISM IN THE INTESTINAL ORGANOIDS MODEL.  Ruslan Dmitriev , Irina Okkelman 1615-Plat 11:15 am NANOSCALE NUCLEAR ENVELOPE DYNAMICS AND SPATIAL ORGANIZA- TION OF THE MUSCULAR DYSTROPHY PROTEIN EMERIN.  Anthony M. Fernandez , Markville B. Bautista, Fabien Pinaud 1616-Plat 11:30 am SUPERRESOLUTION MAPPING OF INTRINSICALLY DISORDERED REGIONS OF NUCLEOPORINS IN SITU. Miao Yu , Nike Andrea Heinss, Sofya Mikhal- eva, Jun Hee Kang, Edward A. Lemke 1617-Plat 11:45 am SUPERRESOLUTION TRACTION FORCE MAPPING WITH STRUCTURED IL- LUMINATION MOLECULAR FORCE MICROSCOPY.  Aaron Blanchard , Dale Combs, Joshua Brockman, Alexa L. Mattheyses, Khalid Salaita 1618-Plat 12:00 pm ACTIVE FEEDBACK 3D SINGLE-MOLECULE TRACKING.  Shangguo Hou , Jack C. Exell, Kevin D. Welsher 1619-Plat 12:15 pm MAPPING PROTEIN COUNTS IN LIVE CELLS.  Derek Thirstrup, Winfried Wiegraebe , Allen Institute for Cell Science Team 1620-Plat 12:30 pm N-COLOR SPATIAL CUMULANT ANALYSIS TO DETECT G-PROTEIN DYNAM- ICS WITH TWO-PHOTON MICROSCOPY.  Daniel J. Foust , David W. Piston Platform Voltage Sensor to Pore Coupling 10:45 am - 12:45 pm, Room 23ABC Co-Chairs Lucie Delemotte, KTH Royal Institute of Technology, Sweden David Fedida, The University of British Columbia, Canada 1621-Plat 10:45 am STRUCTURAL DETERMINANTS OF THE HYPERPOLARIZATION-DEPENDENT GATING OF HCN CHANNELS.  Gucan Dai , William N. Zagotta 1622-Plat 11:00 am GATING MECHANISM OF HYPERPOLARIZATION-ACTIVATED HCN PACEMAKER CHANNELS.  Rosamary Ramentol , Marta E. Perez, Peter H. Larsson 1623-Plat 11:15 am CONSERVED VOLTAGE-DEPENDENT GATING ELEMENTS BETWEEN SHAK- ER AND HERG KV CHANNELS.  Ana I. Fernández-Mariño , Kenton Swartz 1624-Plat 11:30 am IKS ION-CHANNEL PORE CONDUCTANCE CAN RESULT FROM INDIVIDUAL VOLTAGE SENSOR MOVEMENTS.  David Fedida , Maartje F. Westhoff, Jodene R. Eldstrom, Christopher I. Murray, Emely Thompson

ous 8, 16, 48 or 384 parallel patch clamp recordings in conjunction with computer controlled liquid handling and on-board cell handling. Sophion partners with other biotech companies to create robust, ion channel and electrophysiological workflows for drug development for ion channel tar- gets. During this workshop, three industry speakers will provide insight into the use of these systems in the drug discovery process. Dr Sung Hoon Park will present Qube data to show the characterization of rapidly desensitizing α7 nicotinic acetylcholine receptor on the Qube. Next, Dr Shanti Amagasu fromAmgen will present data fromAmgen’s Nav1.1. work on automated electrophysiological platforms. Finally, Dr Abigail Marklew will present on the development of NMDA Assays on the Qube system. Speakers Sung Hoon Park, Field Application Scientist, Sophion Bioscience A/S Shanti Amagasu, Senior Scientist, Amgen Abigail Marklew, Scientist, Charles River Laboratories Exhibits 10:00 am - 4:00 pm, Exhibit Hall Coffee Break 10:15 am - 11:00 am, Exhibit Hall Symposium Awards 10:45 am - 12:45 pm, Ballroom 20A Chair David Piston, Washington University in St. Louis and BPS President No Abstract 10:45 am PAPER OF THE YEAR.  Carlos R. Baiz No Abstract 10:57 am IGNACIO TINOCO AWARD.  Elliot L. Elson No Abstract 11:09 am FOUNDERS AWARD.  Dan M. Herschlag No Abstract 11:21 am MARGARET OAKLEY DAYHOFF AWARD.  Valeria Vásquez No Abstract 11:33 am MICHAEL AND KATE BÁRÁNY AWARD.  Clifford P. Brangwynne No Abstract 11:45 am AVANTI AWARD IN LIPIDS.  Akihiro Kusumi No Abstract 11:57 am BIOPHYSICS IN HEALTH AND DISEASE.  Alexandra C. Newton No Abstract 12:09 pm KAZUHIKO KINOSITA AWARD IN SINGLE MOLECULE BIOPHYSICS.  Yale E. Goldman No Abstract 12:21 pm INNOVATION AWARD.  G. Marius Clore No Abstract 12:33 pm ANATRACE MEMBRANE PROTEIN AWARD.  Gunnar von Heijne

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