Biophysical Society 2020 Annual Meeting

Platform Protein Structure and Conformation III 10:45 am - 12:45 pm, Room 25ABC

1625-Plat 11:45 am CALMODULIN FUNCTIONALLY COUPLES THE KCNQ1 CHANNEL VOLTAGE-SENSING AND PORE DOMAINS.  Po Wei Kang , Annie M. West- erlund, Jingyi Shi, Kelli McFarland White, Alex K. Dou, Jonathan R. Silva, Lucie Delemotte, Jianmin Cui 1626-Plat 12:00 pm STRUCTURE AND PHYSIOLOGICAL FUNCTION OF THE KCNQ1 CHANNEL VOLTAGE SENSOR INTERMEDIATE STATE.  Charles R. Sanders , Keenan C. Taylor, Po Wei Kang, Panpan Hou, Nien-Du Yang, Georg Kuenze, Alfred L. George, Jens Meiler, Robert L. McFeeters, Jianmin Cui 10 1627-Plat 12:15 pm ANIONIC LIPIDS MODULATE STRUCTURE AND FUNCTION OF EPILEPSY- CAUSING VOLTAGE-GATED POTASSIUM CHANNEL.  Shashank Pant , Jiar- en Zhang, Eung Chang Kim, KIn Lam, Hee Jung Chung, Emad Tajkhorshid 1628-Plat 12:30 pm RESIDUES CONNECTING VOLTAGE SENSOR DOMAIN TO PORE DOMAIN IN SHAKER K + CHANNEL BY NONCANONICAL COUPLING MECHANISM.  Carlos Alberto Z. Bassetto Jr , Joao L. Carvalho-de-Souza, Francisco Bezanilla Platform DNA/RNA Structure and Dynamics 10:45 am - 12:45 pm, Room 24ABC Co-Chairs Victoria Birkedal, Aarhus University, Denmark Yue Li, Northwestern University 1629-Plat 10:45 am NETWORK ANALYSIS OF SPLICEOSOMAL STRUCTURES IDENTIFIES STEP- SPECIFIC CHANGES IN CONNECTIVITY.  Clarisse van der Feltz , Harpreet Kaur, Aaron A. Hoskins 1630-Plat 11:00 am STRAND THREADING IN SUBGENOMIC FLAVIVIRUS RNAS GENERATES EXORIBONUCLEASE-RESISTANCE MECHANICALLY. Meng Zhao , Dustin B. Ritchie, Michael T. Woodside 1631-Plat 11:15 am TRANSIENT PROTEIN-RNA INTERACTIONS GUIDE NASCENT RIBOSOMAL RNA FOLDING.  Olivier Duss , Galina A. Stepanyuk, Joseph D. Puglisi, James R. Williamson 1632-Plat 11:30 am CRYO-EM STRUCTURE OF RNASE MRP, A 12-COMPONENT CATALYTIC RI- BONUCLEOPROTEIN COMPLEX.  Andrey S. Krasilnikov , Hyunwook Lee, Carol Bator, Di Li, Igor Berezin, Susan Hafenstein, Anna Perederina 1633-Plat 11:45 am CONFORMATIONAL ENSEMBLES AND DYNAMICS OF SINGLE-STRANDED NUCLEIC ACIDS USING HIGH-RESOLUTION SINGLE-MOLECULE FLUO- RESCENCE SPECTROSCOPY. Mark F. Nueesch , Erik D. Holmstrom, Daniel Nettels, Benjamin Schuler 1634-Plat 12:00 pm QUANTIFYING THREE-DIMENSIONAL CHROMATIN PACKING THROUGH ELECTRON TOMOGRAPHY.  Yue Li , Adam Eshein, Eric Roth, Reiner Ble- her, Vadim Backman 1635-Plat 12:15 pm COHESIN IS A MOTOR THAT BENDS AND COMPACTS DNA. Maxim Molodtsov , Benedikt Bauer, Iain Davidson, Alipasha Vaziri, Jan-Michael Peters 1636-Plat 12:30 pm FOLDING KINETICS OF MULTIPLE G-QUADRUPLEX TELOMERIC DNA STRUCTURES.  Emil L. Kristoffersen, Andrea Coletta, Line Lund, Birgit Schiøtt, Victoria Birkedal

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Co-Chairs George Hamilton, Clemson University Rachel Martin, University of California, Irvine 1637-Plat 10:45 am

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RIC8A-GΑ, A COMPLEX STRUCTURE OF A GUANINE NUCLEOTIDE EX- CHANGE FACTOR.  Levi J. McClelland , Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Jan Steyaert, Wah Chiu, Stephen Sprang 1638-Plat 11:00 am ANALYZING THE SIGNATURE OF GPCR CONFORMATIONAL CHANGES.  Rafeed Khleif , Erik Serrano, Ravinder Abrol 1639-Plat 11:15 am Travel Awardee STRUCTURE-FUNCTION INVESTIGATION OF HAEMOPHILUS INFLUENZAE FERRIC BINDING PROTEIN UNDER CHANGING ENVIRONMENTAL CONDI- TIONS.  Goksin Liu , Canan Atilgan, Zehra Sayers 1640-Plat 11:30 am PROBING THE ROLE OF METAL COORDINATION AND PH IN ASSEMBLY AND FUNCTION OF CYTOCHROME NANOWIRES.  Vishok Srikanth , Yangqi Gu, J. Patrick O’Brien, Ruchi Jain, Sibel Ebru Yalcin, Sophia M. Yi, Fadel A. Samatey, Nikhil S. Malvankar 1641-Plat 11:45 am CONFORMATIONS OF P90 RIBOSOMAL S6 KINASE ACTIVATION.  Evan Kobori , Anita Alexa, Attila Remenyi, Susan S. Taylor 1642-Plat 12:00 pm INTERDOMAIN DYNAMICS UNDERLIE FUNCTION AND REGULATION OF POSTSYNAPTIC DENSITY PROTEIN 95.  George L. Hamilton , Nabanita Saikia, Justin Park, Jakub Kubiak, Claus A. Seidel, Mark E. Bowen, Feng Ding, Hugo Sanabria 1643-Plat 12:15 pm DEAMIDATION OF YD-CRYSTALLIN - EFFECTS ON STRUCTURE AND IN- TERACTION PROPERTIES.  Alex J. Guseman , Matthew J. Whitley, Jeremy Gonzalez, Angela M. Gronenborn 1644-Plat 12:30 pm AGGREGATION OF GAMMA S-CRYSTALLIN MEDIATED BY UV LIGHT AND DIVALENT METAL CATIONS.  Kyle Roskamp, Brenna Norton-Baker, Nata- lia Kozlyuk, Jan Bierma, Suvrajit Sengupta, Rachel W. Martin Platform Protein Stability, Folding, and Chaperones 10:45 am - 12:45 pm, Room 30ABC Co-Chairs UBIQUITINATION MODULATES A PROTEIN ENERGY LANDSCAPE SITE- SPECIFICALLY WITH CONSEQUENCES FOR PROTEASOMAL DEGRADA- TION.  Emma Carroll , Eric R. Greene, Andreas Martin, Susan Marqusee 1646-Plat 11:00 am INVESTIGATION OF NATURAL AND SYNTHETIC AGGREGATION INHIBI- TORS USING MICROFLUIDIC APPLICATIONS.  Tom Scheidt , Jacqueline Carozza, Justin L. Benesch, Paolo Arosio, Sara Linse, Tuomas P.J. Knowles 1647-Plat 11:15 am OPEN AND CLOSED STATES OF THE AAA + PROTEASE LON PROVIDE THE STRUCTURAL BASIS FOR DISTINCT OPERATIONAL MODES. Mia Shin , Cristina Puchades Garcia, Ananya Asmita, Eric Adjei, R. L. Wiseman, A. W. Karzai, Gabriel C. Lander Stephen Fried, Johns Hopkins University Meredith Jackrel, Washington University 1645-Plat 10:45 am

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