Biophysical Society 2020 Annual Meeting

2078-Pos Board B348 3D IMAGING AND MORPHOMETRY OF THE CORONARY MICROCIRCULA- TION IN SPONTANEOUSLY HYPERTENSIVE RATS AND NORMOTENSIVE CONTROLS. Camilla Olianti, Francesco Giardini, Erica Lazzeri, Irene Costan- tini, Claudia Crocini, Leonardo Bocchi, Francesco S. Pavone, Paolo Camici, Leonardo Sacconi 2079-Pos Board B349 UNEQUAL ALLELIC EXPRESSION OF MUTATED CARDIAC TROPONIN I FROM CELL-TO-CELL MAY INDUCE CONTRACTILE IMBALANCE IN HY- PERTROPHIC CARDIOMYOPATHY. Valentin Burkart , Julia Beck, Kathrin Kowalski, Jolanda van der Velden, Cris G. dos Remedios, Judith Montag, Theresia Kraft 2080-Pos Board B350 MICROTUBULE ACETYLATION REGULATES STRIATED MUSCLE MECHANO- TRANSDUCTION. Andrew K. Coleman , Humberto Cavalcante Joca, Guoli Shi, W. Jonathan Lederer, Christopher W. Ward 2081-Pos Board B351 MICROLED ILLUMINATION TOWARDS LIQUID CRYSTALLINE ELASTOMERS BASED CARDIAC CONTRACTION ASSISTANCE. Silvia Querceto , Cecilia Fer- rantini, Bruno Grandinetti, Daniele Martella, José Manuel Pioner, Diederik Sybolt Wiersma, Elisabetta Cerbai, Francesco Saverio Pavone, Chiara Tesi, Corrado Poggesi, Leonardo Sacconi, Camilla Parmeggiani 2082-Pos Board B352 ALTERED THICK AND THIN FILAMENT STRUCTURAL DYNAMICS IN MOUSE MYOCARDIUM DUE TO ABLATION AND PHOSPHORYLATION OF MYOSIN BINDING PROTEIN-C. Alexey Dvornikov , Thomas A. Bunch, Victoria C. Lepak, Brett A. Colson 2083-Pos Board B353 Travel Awardee IMPACT OF REGULATORY LIGHT CHAIN MUTATION (K104E) ON THE ATPASE AND MOTOR PROPERTIES OF HUMAN CARDIAC MYOSIN. David Rasicci, Orville Kirkland , Wanjian Tang, Rohini Desetty, Christopher M. Yengo 2084-Pos Board B354 EXPLORING MECHANICAL LOAD-INDUCED CARDIAC REMODELLING US- ING A NOVEL ORGANOTYPIC MYOCARDIAL SLICE MODEL. Fotios G. Pitoulis , Raquel Nunez-Toldra, Worrapong Sam Kit-Anan, Eef Dries, Ifige- neia Bardi, Filippo Perbellini, Sian E. Harding, Pieter P. de Tombe, Cesare M. Terracciano 2085-Pos Board B355 NUCLEOTIDE-DEPENDENT ALLOSTERIC COMMUNICATION IN MYO- SIN. Matthew C. Childers , Valerie Daggett, Michael Regnier 2086-Pos Board B356 THE ROLE OF MYOPALLADIN IN CARDIAC MUSCLE FUNCTION AND DIS- EASE. Vinay Kumar Kadarla 2087-Pos Board B357 ROLE OF A FUNCTIONAL SNP OF THE GENE CODING BRAIN SEROTONIN SYNTHESIS RATE-LIMITING ENZYME TPH2 IN DILATED CARDIOMYOPA- THY. Sachio Morimoto , Kengo Hayamizu, Miki Nonaka, Lei Li, Yuanyuan Wang 2088-Pos Board B358 ENGINEERING SYNTHETIC DNA NANOTUBE THICK FILAMENTS TO DIS- SECT BETA-CARDIAC MYOSIN AND CARDIAC MYOSIN-BINDING PROTEIN C INTERACTIONS. Anja M. Touma , Ashim Rai, Christopher M. Yengo, Samantha B. Previs, David M. Warshaw, Sivaraj Sivaramakrishnan 2089-Pos Board B359 MEASUREMENTS OF ACTIN LAYER LINES IN PERMEABILIZED HEART TISSUE REVEAL NEW STRUCTURAL PROPERTIES OF THE CARDIAC THIN FILAMENT. Maicon Landim Vieira , Weikang Ma, Jamie Johnston, Prescott B. Chase, Thomas C. Irving, J. Renato D. Pinto

2090-Pos Board B360 CLASSIFICATION OF GENETIC CARDIAC MUTATIONS USING COMPUTA- TIONAL CHEMISTRY. Allison B. Smith , Anthony P. Baldo, Jil C. Tardiff, Steven D. Schwartz 2091-Pos Board B361 HIPSCS DERIVED CARDIOMYOCYTES OVEREXPRESSING DEOXY ATP TO RESTORE CARDIAC FUNCTION. Ketaki N. Mhatre , Julie Mathieu, Charles E. Murry, Michael Regnier 2092-Pos Board B362 INTRINSIC MODIFIER EFFECT OF CTNT ISOFORM SWITCHING IN SARCO- MERIC CARDIOMYOPATHIES. Melissa L. Lynn , Lauren Grinspan, Catherine Vasquez, Teryn A. Holeman, Jian-Ping Jin, Jil C. Tardiff 2093-Pos Board B363 IMPACT OF ANTI-S2 PEPTIDES ON MYOSIN S2 ISOFORMS AND HCMMU- TANTS. Negar Aboonasrshiraz , Douglas D. Root 2094-Pos Board B364 TIME-RESOLVED FRET CONFIRMS HUMAN CARDIAC MYOSIN HEAD-TAIL INTERACTION. Alexandra N. Hurst , Shiril Bhardwaj, Akhil Gargey, Yuri Board B365 RAPID TRANSITIONS BETWEEN THE OFF AND ON STATES OF MYOSIN CONTRIBUTE TO CONTRACTION-RELAXATION COUPLING IN CARDIAC MUSCLE. Faruk H. Moonschi , Kenneth S. Campbell Board B366 MOLECULAR INSIGHTS INTO DYNEIN AUTOINHIBITION. Matthew G. Marzo 2097-Pos Board B367 SINGLE-MOLECULE IMAGING OF CYTOPLASMIC DYNEIN IN VIVO REVEALS THE MECHANISM OF MOTOR ACTIVATION AND CARGO CAPTURE.  Nireekshit Addanki Tirumala 2098-Pos Board B368 HIGH RESOLUTION CRYO-EM STRUCTURES OF DYNACTIN’S SHOULDER AND POINTED END. Clinton K. Lau , Andrew Carter 2099-Pos Board B369 COILED-COIL REGISTRY SHIFTS IN THE F684I MUTANT OF BICAUDAL RE- SULT IN CARGO-INDEPENDENT ACTIVATION OF DYNEIN MOTILITY. Heying Cui, Kathleen M. Trybus, M. Yusuf Ali, Puja Goyal, Xavier D. Aura, Jia-Ying Loh, Crystal R. Noell, Sozanne R. Solmaz 2100-Pos Board B370 LIS1 PROMOTES THE FORMATION OF ACTIVATED CYTOPLASMIC DYNEIN-1 COMPLEXES.  John P. Gillies , ZawMin Htet, Richard W. Baker, Andres Leschziner, Morgan E. DeSantis, Samara L. Reck-Peterson 2101-Pos Board B371 THE REGULATORY ROLE OF LIS1 ON THE MECHANICS OF DYNEIN MOTIL- ITY. Emre Kusakci 2102-Pos Board B372 CARGO ADAPTORS REGULATE THE STEPPING AND FORCE GENERATION OF MAMMALIAN DYNEIN-DYNACTIN.  John Canty 2103-Pos Board B373 OSCILLATORY MOVEMENT OF A DYNEIN-MICROTUBULE COMPLEX CROSS- LINKED WITH DNA-ORIGAMI. Shimaa A. Abdellatef, Hisashi Tadakuma, Yuichi Kondo, Kangmin Yan, Rofia Boudria, Kodai Fukumoto, Takashi Fuji- wara, Hideo Higuchi, Keiko Hirose Nesmelov 2095-Pos Kinesins and Dyneins (Boards B366 - B392) 2096-Pos

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