Biophysical Society 2020 Annual Meeting

2104-Pos Board B374 KINETICS & THERMODYNAMICS OF KINESIN BACKSTEPS. Huong T. Vu , Algirdas Toleikis, Nicholas Carter, Robert A. Cross 2105-Pos Board B375 PROPOSED MECHANISM OF KINESIN BACKSTEPPING. Algirdas Toleikis , Nicholas Carter, Robert A. Cross 2106-Pos Board B376 SYNCHRONIZED UNIDIRECTIONAL-ROTATION AND HELICAL-MOTION OF KINESIN-BOUND GOLD NANORODS INDICATES COUPLING OF TORQUE AND LATERAL-FORCE GENERATIONS OF KINESIN HEADS. Mitsuhiro Sugawa , Yohei Maruyama, Masahiko Yamagishi, Robert A. Cross, Ju- nichiro Yajima 2107-Pos Board B377 STRAIN-DEPENDENT PROPERTIES OF KIF3A AND KIF3C TUNE THE MECH- ANOCHEMISTRY OF THE KIF3AC HETERODIMER. Brandon M. Bensel , Michael S. Woody, Serapion Pyrpassopoulos, Yale E. Goldman, Susan P. Gilbert, E. Michael Ostap 2108-Pos Board B378 Travel Awardee THE TAIL OF XCTK2 CONTAINS TWO DISTINCT MICROTUBULE BINDING DOMAINS. Stephanie C. Ems-McClung , Stephanie Zhang, Mackenzie Emch, Claire E. Walczak 2109-Pos Board B379 INHIBITORY MECHANISM OF PHOTOCHROMIC INHIBITOR FOR MITOTIC KINESIN EG5. Kei Sadakane , IslamMd Alrazi, Kenichi Taii, Tomisin H. Ogunwa, Takayuki Miyanishi, Shinsaku Maruta 2110-Pos Board B380 CARGO DIFFUSION SHORTENS SINGLE-KINESIN RUNS AT LOW VISCOUS DRAG.  John O. Wilson , David A. Quint, Ajay Gopinathan, Jing Xu 2111-Pos Board B381 IN VITRO RECONSTITUTION OF KINESIN-DRIVEN VESICLE TRANSPORT. Rui Jiang , Qingzhou Feng, You Jung Kang, William O. Hancock 2112-Pos Board B382 BIOCHEMICAL CHARACTERIZATION OF THE KIF1A CHEMOMECHANICAL CYCLE. Taylor M. Zaniewski , William O. Hancock 2113-Pos Board B383 MOTILITY CHARACTERISTICS OF HUMAN KIF1A MUTANTS IN HIPPOCAM- PAL NEURONS IN RELATION TO HEREDITARY SPASTIC PARAPLEGIA. Shiori Matsumoto , Kyoko Chiba, Shinsuke Niwa, Kumiko Hayashi 2114-Pos Board B384 TRACKING DOWN THE FAST AND SUPERPROCESSIVE KIF1A WITH GOLD SCATTERING MICROSCOPY. Allison M. Gicking 2115-Pos Board B385 REGULATION OF KIF1A BEHAVIOR AND MOTILITY VIA TAU’S STRUCTURAL DYNAMICS. Dominique V. Lessard , Christopher L. Berger 2116-Pos Board B386 THREE-DIMENSIONAL MODEL TO UNDERSTAND THE COOPERATIVE TRANSPORT OF PAIRS OF KINESIN-2 MOTORS. Wiphu Youyen , Punam Sonar, Pattipong Wisanpitayakorn, Qingzhou Feng, Keith J. Mickolajczyk, William O. Hancock, Zeynep Okten, Erkan Tüzel 2117-Pos Board B387 THE ROLE OF GLYCOGEN SYNTHASE KINASE 3 (GSK3) IN REGULATING INTRACELLULAR TRANSPORT.  Ibtissem Nabti , George T Shubeita 2118-Pos Board B388 SMALL MOLECULE UNCOUPLING OF MICROTUBULE DEPOLYMERASE AC- TIVITY FROMMOTILITY IN HUMAN KINESIN-5 DURING MITOTIC SPINDLE ASSEMBLY. Edward Wojcik

2119-Pos Board B389 DEVELOPMENT OF NOVEL PHOTOCHROMIC INHIBITORS FOR KINESIN EG5 WHICH FORMMULTIPLE ISOMERIZATION STATES UTILIZING AZOBEN- ZENE AND SPIROPYRAN.  IslamMd Alrazi , Kei Sadakane, Shinsaku Maruta 2120-Pos Board B390 Travel Awardee INVESTIGATING THE ROLE OF CARGO SHAPE AND MOTOR ATTACHMENT GEOMETRY IN THE ENSEMBLE MOTILITY OF TEAMS OF CYTOSKELETAL MOTORS DYNEIN AND KINESIN.  Jingjie Hu , Yang Yang, Chenxiang Lin, Nathan D. Derr 2121-Pos Board B391 MOLECULAR MECHANISM OF RAB22A MEDIATED REGULATION OF KI- F13A MOTILITY AND CARGO RECYCLING. Nishaben Patel , Prerna Sharma, Ruchi Kumari, Aravintha Siva, Subba Rao Setty, Virupakshi Soppina 2122-Pos Board B392 MOLECULAR NANO-PATTERNING REVEALS DIFFERENT COORDINATION OF KINESIN-1 AND KINESIN-14 MOTORS. Taikopaul Kaneko , Kenya Fu- ruta, Kazuhiro Oiwa, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa Myosins (Boards B393 - B412) 2123-Pos Board B393 Travel Awardee ELECTROSTATIC INTERACTIONS WITHIN HUMAN CARDIAC MYOSIN HEAD MODULATE ITS KINETICS. Akhil Gargey , Shiril Bharadwaj, Yaroslav V. Tkachev, Yuri E. Nesmelov 2124-Pos Board B394 FUNCTIONAL COMPARISON OF HOMOLOGOUS MUTATIONS IN HUMAN BETA, PERINATAL, AND EMBRYONIC MUSCLE MYOSIN ISOFORMS. Anas- tasia Karabina , Chao Liu, James A. Spudich, Leslie A. Leinwand 2125-Pos Board B395 Travel Awardee FUNCTIONAL DIFFERENCES IN MYH7B THAT CONTRIBUTE TO DISTINCT BIOLOGICAL ROLES ACROSS SPECIES AND IN HEALTH AND DISEASE. Lind- sey A. Lee , Anastasia Karabina, Leslie A. Leinwand 2126-Pos Board B396 MOLECULAR MECHANISM OF MYOSIN-7A TRANSLOCATION AND ACTIN BUNDLE ASSEMBLY INSIGHTS FROM A NEW BINDING PROTEIN. Rong Liu , Neil Billington, Yi Yang, Charles Bond, Amy Saw-Tin Hong, Yasuharu Takagi, Verl B. Siththanandan, James R. Sellers 2127-Pos Board B397 MYO3A MOTOR ACTIVITY AND TAIL DOMAIN INTERACTIONS IMPACT AC- TIN PROTRUSION ELONGATION. Laura Gunther , Shane R. Nelson, Joseph A. Cirilo, David M. Warshaw, Christopher M. Yengo 2128-Pos Board B398 MYOSIN MOTORS’ KINETIC DIVERSITY IS ENCODED BY THE CONFOR- MATIONAL DYNAMICS OF THE MOTOR DOMAIN.  Justin R. Porter , Artur Meller, Maxwell I. Zimmerman, Michael J. Greenberg, Gregory Bowman 2129-Pos Board B399 FLEXIBILITY OF MYOSIN II IN SOLUTION. Prince Tiwari , Kyounghwan Lee, Osamu Sato, Mitsuo Ikebe, Roger Craig 2130-Pos Board B400 THE NEW-GENERATION MUSCLE RELAXANT MPH-220 DISSOLVES SPASTICITY IN MUSCLES AFTER CNS INJURY - A PROMISING DRUG TO ADDRESS POST-STROKE SPASTICITY. Mate Gyimesi, Adam I. Horvath , Demeter Túrós, Gyorgy Hegyi, Sharad K. Suthar, Mihaly Kovacs, Andras Malnasi-Csizmadia 2131-Pos Board B401 TARGETED MYOSIN-2 INHIBITION IMPROVES BRAIN REGENERATION AFTER STROKE BY RELAXING HYPOXIA-INDUCED VASOCONSTRICTION IN CAPILLARIES. Mate Penzes, Demeter Turos, Mate Winternitz, Ivan Ivic, Peter Toth, Anna Á. Rauscher, Mate Gyimesi , Andras Malnasi-Csizmadia

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