Biophysical Society 2020 Annual Meeting

2185-Pos Board B455 Travel Awardee DETERMINATION OF THE NUMBER OF PERMEABILITY TRANSITION PORES IN SINGLE MITOCHONDRION. Maria A. Neginskaya , Jasiel O. Strubbe, Giuseppe F. Amodeo, Jason N. Bazil, Evgeny V. Pavlov 2186-Pos Board B456 ACETYLATION OF CYCLOPHILIN D INCREASES CALCIUM SENSITIVITY OF THE PERMEABILITY TRANSITION PORE. Gisela Beutner, George A. Porter 2187-Pos Board B457 IDENTIFICATION OF ROLE OF MITOCHONDRIAL CHLORIDE INTRACELLU- LAR CHANNEL (CLIC) PROTEIN, CLIC4 AND CLIC5 IN CARDIOPROTECTION FROM IR INJURY VIA PROBABLY MODULATING THE OPENING OF MPTP PORE. Devasena Ponnalagu , Piotr Bednarczyk, Jessica Weist, Erhe Gao, Walter Koch, Mahmood Khan, AdamM. Szewczyk, Harpreet Singh 2188-Pos Board B458 STRUCTURAL AND FUNCTIONAL ALTERATIONS IN SINOATRIAL NODE MI- TOCHONDRIA DURING HEART FAILURE. Lu Ren, Xiao-Dong Zhang, Elena N. Dedkova, Phung N. Thai , Nipavan Chiamvimonvat 2189-Pos Board B459 SPATIOTEMPORAL SUBCELLULAR CHARACTERIZATION OF ABSOLUTE NADH CONCENTRATION OVER THE DYNAMIC COURSE OF METAPHASE, ANAPHASE, TELOPHASE AND CYTOKINESIS USING THE PHASOR AP- PROACH TO FLIM. Rachel Cinco , Ny’Kerria Leonard, Michelle A. Digman, Enrico Gratton 2190-Pos Board B460 THERAPEUTIC CONCENTRATIONS OF STATINS HYPERPOLARIZE MITO- CHONDRIA AND INHIBIT CELL PROLIFERATION WITHOUT PROMOTING CELL DEATH IN HEPATOCARCINOMA CELLS. Elizabeth G. Hunt , Diana Fang, Amandine Rovini, Charleston F. Christie, Kareem A. Heslop, Eduardo N. Maldonado 2191-Pos Board B461 MONITORING CAMKII IN MITOCHONDRIA. Kevin R. Murphy , Qinchuan Wang, Jonathan Granger, Vedika Karandikar, Gianna Bortoli, Xi Zhang, Elizabeth Luczak, Rong Li, Mark E. Anderson 2192-Pos Board B462 AGED DIABETIC MICE EXHIBIT DIASTOLIC DYSFUNTION ASSOCIATED WITH ALTERATIONS IN MYOCARDIAL MITOCHONDRIAL OXIDATIVE PHOS- PHORYLATION PROTEIN EXPRESSION AND COMPLEX ASSEMBLIES. Wen- zhou MA, Scarlett Huck, Thomas Mancini, Alex Vang, Shanna Hamilton, Radmila Terentyeva, Dmitry A. Terentyev, Gaurav Choudhary, Richard T. Board B463 MEMBRANE INTERACTION OF MITOCHONDRIAL INTERMEMBRANE SPACE KINASES. Uwe Schlattner 2194-Pos Board B464 TRIC-A CHANNEL MODULATES CA 2+ HOMEOSTASIS IN MITOCHON- DRIA. Ang Li , Xuejun Li, Jianxun Yi, Xinyu Zhou, Ki Ho Park, Miyuki Nishi, Hiroshi Takashima, Jianjie Ma, Jingsong Zhou 2195-Pos Board B465 ROLE OF MITOCHONDRIAL EXPRESSION OF THE CALCIUM-ACTIVATED CHLORIDE CHANNEL ANOCTAMIN-1 IN PULMONARY ARTERY ENDO- THELIAL CELLS.  Jin O-Uchi , Alexander Vang, Michael W. Cypress, Ana Fernandez-Nicolas, Thomas Mancini, Bong Sook Jhun, Richard T. Cle- ments, Gaurav Choudhary 2196-Pos Board B466 REDUCED AFFINITY OF MITOCHONDRIAL VDAC3 FOR CYTOSOLIC PRO- TEINS REVEALS A MECHANISM FOR VDAC ISOFORM-SPECIFIC PHYSIOL- OGY. Maria Queralt-Martín , Lucie A. Bergdoll, Jeff Abramson, Sergey M. Bezrukov, Tatiana K. Rostovtseva Clements 2193-Pos

2197-Pos Board B467 PERIPHERAL BINDING OF HEXOKINASE-2 TO THE RIM OF VDAC1 MEDI- ATED BY THE MITOCHONDRIAL OUTER MEMBRANE. Nandan Haloi , Po-Chao Wen, Qunli Cheng, Meiying Yang, Amadou K. Camara, Wai-Meng Kwok, Emad Tajkhorshid 2198-Pos Board B468 Travel Awardee OXIDATIVE THIOL MODIFICATIONS AS MOLECULAR REDOX SENSORS IN HUMAN MITOCHONDRIA. Radhakrishnan Mahalakshmi 2199-Pos Board B469 MULTI-MODAL ACTIONS OF BAX AND BTSA1 ON MITOCHONDRIAL BIO- ENERGECTICS AND MEMBRANE INTEGRITY.  Jonathan Feng , Qunli Cheng, Gayathri K. Natarajan, Amadou K. Camara, Wai-Meng Kwok 2200-Pos Board B470 PROTON TRANSPORT IN MITOCHONDRIAL UCP2 IS REGULATED BY A MATRIX-ORIENTED SALT-BRIDGE NETWORK. Afshan Ardalan, Shahin Sowlati-Hashjin, Mikko Karttunen, Matthew D. Smith, Masoud Jelokhani- Niaraki 2201-Pos Board B471 PROTONIC CAPACITOR BIOENERGETICS: WHY MITOCHONDRIA DEVELOP CRISTAE?  James W. Lee 2202-Pos Board B472 MITOCHONDRIAL REDOX SIGNALING AND CRISTAE MORPHOLOGY CHANGES UPON 2-KETO-ISOCAPROATE AND FATTY ACID-STIMULATED INSULIN SECRETION. Petr Jezek , Blanka Holendova, Martin Jaburek, Jan Tauber, Lydie Plecitá-Hlavatá, Andrea Dlaskova 2203-Pos Board B473 MITOCHONDRION REIMAGINED - FUELING SYNTHETIC LIFE. Lado Otrin , Christoph Diehl, Tobias Erb, Kai Sundmacher, Tanja Vidaković-Koch 2204-Pos Board B474 ENHANCED O2-DEPENDENT MITOCHONDRIAL ACTIVATION IN MYOFI- BERS FROM CMP N -GLYCOLYLNEURAMINIC ACID HYDROXYLASE (CMAH) GENE INACTIVATED MICE. Leonardo Nogueira , Ellen C. Breen 2205-Pos Board B475 STUDY OF THE MECHANISMS ASSOCIATED WITH PM 2.5 INDUCED REAC- TIVE OXYGEN SPECIES PRODUCTION IN ALVEOLAR MACROPHAGES. David Flores , Micah B. Olivas, Mandeep Kaur, Kosha Raval, Joel Castillo, Anthony Waterston, Alam Hasson, Laurent M. Dejean Systems Biology and Disease (Boards B476 - B488) 2206-Pos Board B476 NON- EQUILIBRIUM ENTROPY OF CANCER BASED ON GOMPERTZIAN GROWTH. Preet Sharma , Randal Hallford, Salvatore Capotosto, Bailey Smoot 2207-Pos Board B477 A BIOPHYSICAL BASIS FOR A TARGETED THERAPY EXCEPTIONAL RE- SPONDER KRAS MUTATION. Edward C. Stites , Thomas McFall 2208-Pos Board B478 BIOPHYSICAL MODEL OF ION TRANSPORT AND ENERGY DEPLETION IN THE INNER EAR. Julia Lasater, Robert M. Raphael 2209-Pos Board B479 ZEBRAFISH AIRINEME TARGET SEARCH AND OPTIMAL CURVATURE.  Sohyeon Park , Hyunjoong Kim, Dae Seok Eom, Jun F. Allard 2210-Pos Board B480 DETERMINANTS OF INFLUENZA A DIFFUSION THROUGH THE MUCUS BARRIER TO INFECTION. Logan Kaler , Shahed Bader, Gregg Duncan

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