Biophysical Society 2020 Annual Meeting

Membrane Pumps, Transporters, and Exchangers II (Boards B430 - B448) 2160-Pos Board B430 ZINC-INDUCED CONFORMATIONAL CHANGES IN THE CATION DIFFUSION FACILITATOR YIIP. Maria L. Lopez , Akiko Koide, Lorena Novoa, Jose M Arguello, Shohei Koide, David L. Stokes 2161-Pos Board B431 MECHANISM OF ION PERMEATION IN THE EUKARYOTIC COPPER TRANS- PORTER CTR. Kehan Chen , Yaping Pan, Ming Zhou 2162-Pos Board B432 MICROSCOPIC VIEW OF STRUCTURAL TRANSITIONS OF GLUCOSE TRANS- PORTERS. Tianle Chen , Mrinal Shekhar, Emad Tajkhorshid 2163-Pos Board B433 COOPERATIVE SUBSTRATE BINDING CONVERGES TO THE CLOSED CONFORMATIONS IN THE SODIUM-COUPLED MELIBIOSE SYMPORTER MELB. Hariharan Parameswaran , Lan Guan 2164-Pos Board B434 MITOCHONDRIAL ATP SYNTHASE UTILIZES BOTH K + AND H + CONDUC- TANCESTO DRIVE ATP SYNTHESIS. Evgeny Kobrinsky , Dmitry B. Zorov, Magdalena Juhaszova, Miguel A. Aon, Sonia Cortassa, Steven J. Sollott 2165-Pos Board B435 ALTERNATING BINDING OF PHOSPHOLAMBAN AND DWORF TO SERCA DURING TRANSIENT ELEVATIONS OF CYTOSOLIC CALCIUM. Sean R. Cleary , Ellen E. Cho, Marsha P. Pribadi, Elisa Bovo, Jordan R. Beach, How- ard S. Young, Aleksey V. Zima, Gianluigi Veglia, Seth L. Robia 2166-Pos Board B436 DEFINING SUBSTRATE BINDING SITE IN SODIUM-DEPENDENT BILE ACID TRANSPORTERS. Azaan Wilbon , Corinne Portiolli, Lie Wang, Ming Zhou 2167-Pos Board B437 BILE ACID TRANSPORT BY THE SYMPORTER ASBT NM : SUBSTRATE BIND- ING AND CONFORMATIONAL CHANGE. Fiona Naughton , Patrick Becker, Deborah Brotherton, Alexander D. Cameron, Oliver Beckstein 2168-Pos Board B438 ELUCIDATION OF STRUCTURAL DOMAINS UNDERLYING SUBSTRATE REC- OGNITION IN PLANT MATE TRANSPORTERS. Srinivasan Krishnan , Janin Riedelsberger, Julia Miller, Miguel Pineros 2169-Pos Board B439 SIMULATION AND FRET ANALYSES OF SERCA, PHOSPOHLAMBAN, AND SARCOLIPIN COMPLEXES. Bengt Svensson , Joseph M. Autry, Tory M. Schaaf, Razvan L. Cornea, David D. Thomas 2170-Pos Board B440 DETECTING MILLISECOND TIME RESOLUTION OF GLTPH DYNAMICS BY HS-AFM LINE SCANNING. Tina R. Matin , George R. Heath, Gerard Huys- mans, Olga Boudker, Simon Scheuring 2171-Pos Board B441 A KINETIC DESCRIPTION OF CYTOSOLIC K + BINDING TO THE HUMAN SER- TOTONIN TRANSPORTER UNDER TURNOVER CONDITIONS. Zhiyu Zhao , Emad Tajkhorshid 2172-Pos Board B442 A NOVEL STRUCTURAL MODEL OF THE CREATINE TRANSPORTER RATIO- NALIZES ITS STRUCTURAL DETERMINANTS OF BINDING. Giulia Banci, Riccardo Martini, Claire Colas , Gerhard Franz Ecker

2173-Pos Board B443 INVESTIGATING CONFORMATIONAL CHANGES TO UNDERSTAND THE TRANSPORT MECHANISM OF CLC CHLORIDE/PROTON ANTIPORT- ERS. Tanmay Chavan , Ricky Cheng, Tao Jiang, Irimpan I. Mathews, Richard A. Stein, Antoine Koehl, Ayush Krishnamoorti, Ryan J. Durham, Vladimir Berka, Hassane Mchaourab, Emad Tajkhorshid, Vasanthi Jayaraman, Merritt Maduke 2174-Pos Board B444 MOLECULAR DETERMINANTS OF PROTON TRANSFER IN ATP SYNTHASE F O COMPLEX. Antoni Marciniak , Pawel Chodnicki, Joanna Slabonska, Jacek Czub 2175-Pos Board B445 IDENTIFICATION OF A SUBSTRATE BINDING SITE ON THE MITOCHON- DRIAL TRANSPORTER ABCB10. Alexandra D. Saxberg , Melissa Martinez, Maria E. Zoghbi 2176-Pos Board B446 ALLOSTERIC COUPLING IN AN ASYMMETRIC ABC TRANSPORTER. Cinthia R. Millan , Martina Francis, Valery Thompson, Tarjani M. Thaker, Thomas Board B447 CONFORMATIONAL CHANGES DURING THE ATP HYDROLYSIS CYCLE OF THE MULTIDRUG TRANSPORTER P-GLYCOPROTEININ RESPONSE TO SUB- STRATE BINDING. Courtney Katz , Mariana C. Fiori, Benjamin T. Jackson, Ina Urbatsch, Guillermo A. Altenberg 2178-Pos Board B448 ATOMISTIC MOVIE OF SUBSTRATE TRANSPORT IN AN ABC EXPORT- ER. Hendrik Göddeke, Lars V. Schäfer Mitochondria in Cell Life and Death (Boards B449 - B475) 2179-Pos Board B449 C SUBUNIT OF THE ATP SYNTHASE IS AN AMYLOIDOGENIC CHANNEL- FORMING PEPTIDE: POSSIBLE IMPLICATIONS IN MITOCHONDRIAL PATHO- GENESIS. Giuseppe F. Amodeo , Brenda Y. Lee, Natalya Krilyuk, Carina T. Filice, Denis Valyuk, Daniel E. Otzen, Sergei Y. Noskov, Zoya Leonenko, Evgeny V. Pavlov 2180-Pos Board B450 MECHANISM OF ALPHA-SYNUCLEIN TRANSLOCATION INTO MITOCHON- DRIA. Megha Rajendran , Marie-Paule Strub, Maria Queralt-Martin, Wil- liamM. Rosencrans, Sergey M. Bezrukov, Tatiana K. Rostovtseva 2181-Pos Board B451 DELIVERY OF SINGLET OXYGEN INTO NEURONS STIMULATES MITOCHON- DRIAL ENERGY METABOLISM. Plamena R. Angelova , Sergey G. Sokolovs- ki, Edik U. Rafailov, Andrey Y. Abramov 2182-Pos Board B452 DELAYED PATHOPHYSIOLOGY OF MILD TRAUMATIC BRAIN INJURY: THE DIMINISHED ROLE OF CA 2+ BUFFERING CAPACITY OF CEREBRAL MITO- CHONDRIA. Armaan Zare , Keguo Li, KareemM. Malas, James S. Heisner, Jyotsna Mishra, David F. Stowe, Wai-Meng Kwok, Amadou K. Camara 2183-Pos Board B453 BUTYRATE MODULATES MITOCHONDRIAL BIOENERGETICS OF CULTURED MOTOR NEURON CELLS WITH OVEREXPRESSION OF AN ALS MUTATION SOD1 G93A . Xuejun Li , Jianxun Yi, Ang Li, Marco A. Brotto, Jingsong Zhou 2184-Pos Board B454 MITOCHONDRIAL TRANSLOCATOR PROTEIN (TSPO) PREVENTS HEART FAILURE BY INCREASING CARDIAC UTILIZATION OF FATTY ACIDS. Phung Thai, Anthony W. Herren, Lu Ren, Donald M. Bers, Saul Schaefer, Elena N. Dedkova Tomasiak 2177-Pos

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