Biophysical Society 2020 Annual Meeting

Symposium New and Notable 1:00 pm - 3:00 pm, Ballroom 20A

2394-Plat 9:45 am DISSECTING THE SYNERGISTIC ROLES OF SYNAPTOTAGMIN AND COMPLEXIN IN CA 2+ -REGULATED EXOCYTOSIS.  Sathish Ramakrishnan, Manindra Bera, Jeff Coleman, Frederic Pincet, James Rothman, Shyam S. Krishnakumar 2395-Plat 10:00 am FUSION PORES ARE COOPERATIVELY DILATED BY THE NEURONAL CAL- CIUM SENSOR SYT1 AND SNARE PROTEINS IN A MECHANICAL LEVER ACTION.  Nadiv Dharan, Sathish Thiyagarajan , Zhenyong Wu, Erdem Karatekin, Ben O’Shaughnessy Platform Protein-Nucleic Acid Interactions 8:15 am - 10:15 am, Room 31ABC Co-Chairs Kumar Sarthak, University of Illinois Urbana-Champaign Judong Fu, The Ohio State University 2396-Plat 8:15 am TRANSIENT BINDING AND NON-ROTATIONAL COUPLED MOTION OF P53 REVEALED BY SUB-MILLISECOND RESOLVED SINGLE-MOLECULE FLUO- RESCENCE TRACKING.  Dwiky R.G. Subekti , Satoshi Takahashi, Kiyoto 8:30 am CRYO-EM STRUCTURE OF SUBSTRATE-ENGAGED NUCLEAR EXOSOME TARGETING (NEXT) COMPLEX. Marc Rhyan Puno , Christopher D. Lima 2398-Plat 8:45 am DNA SEQUENCE AND HISTONE CORE COMPOSITION DETERMINE THE UNWRAPPING PATHWAYS IN NUCLEOSOMES.  Alex Mauney , Lois Pollack 2399-Plat 9:00 am Travel Awardee THE UNCONVENTIONAL BIOPHYSICAL FUNCTION OF MICRORNA-1 IN MODULATING CARDIAC ELECTROPHYSIOLOGY.  Dandan Yang 2400-Plat 9:15 am MICROSCOPIC DESCRIPTION OF PROTEIN-RNA INTERACTIONS IN NUCLEOPROTEIN CONDENSATES.  Kumar Sarthak , Swan Htun, Aleksei Aksimentiev 2401-Plat 9:30 am A DNA ORIGAMI PLATFORM FOR SINGLE-PAIR FÖRSTER RESONANCE ENERGY TRANSFER INVESTIGATION OF DNA-DNA AND DNA-PROTEIN INTERACTIONS.  Kira Bartnik , Anders Barth, Mauricio Pilo-Pais, Alvaro H. Crevenna, Tim Liedl, Don C. Lamb 2402-Plat 9:45 am OBSERVING SINGLE-MOLECULE PROTEIN-DNA INTERACTIONS AND DNA TRANSCRIPTION IN VITRO USING TRANSCRIPTOMIC TETHERED PARTICLE MOTION.  Emilius Visser , Jovana Miladinovic, Joshua Milstein 2403-Plat 10:00 am IMAGING AND MECHANICS OF INFECTIOUS DNA EJECTION BY THE T7 BACTERIOPHAGE.  Balint Kiss , Hedvig Tordai, Levente Herenyi, Miklós S.Z. Kellermayer Poster Presentations and Late Posters 10:30 am - 12:30 pm, Exhibit Hall Kamagata 2397-Plat

W E

Co-Chairs Patricia Clark, University of Notre Dame William Kobertz, University of Massachusetts Medical School no abstract 1:00 pm SINGLE-MOLECULE TRAINSPOTTING: STUDIES OF EUKARYOTIC GENOME MAINTENANCE. Gheorghe Chistol NO ABSTRACT 1:30 PM COUPLING MOLECULAR ACTIVATION AND ITS FUNCTIONAL OUTPUT THROUGH MULTISCALE IMAGING. Dorit Hanein NO ABSTRACT 2:00 PM HOW INFLUENZA HEMAGGLUTININ ACTS WITHIN MEMBRANES TO DRIVE MEMBRANE FUSION. Peter Kasson NO ABSTRACT 2:30 PM LIPIDS AND CATIONS AS COUPLED REGULATORS OF MEMBRANE PROTEIN INSERTION AND FOLDING. Alexey S. Ladokhin Symposium Personalized Medicine: Protein Sequence Chair Christian Landry, Laval University, Canada 2404-Symp 1:00 pm MAKING AND MEASURING THE EFFECT OF MUTATIONS ON A MASSIVE SCALE.  Douglas M. Fowler 2405-Symp 1:30 pm DECODING MOLECULAR MECHANISMS OF DISEASE WITH MEDICAL BIO- PHYSICS.  Anna Panchenko No Abstract 2:00 pm EVOLUTION-GUIDED DISSECTION AND ENHANCEMENT OF RESTRICTION OF VIRUSES BY HOST ANTIVIRAL PROTEINS.  Harmit Malik 2406-Symp 2:30 pm PARALOG DEPENDENCY INDIRECTLY AFFECTS THE ROBUSTNESS OF HU- MAN CELLS.  Christian Landry , Rohan Dandage Platform Intrinsically Disordered Proteins (IDP) and Aggregates III 1:00 pm - 3:00 pm, Ballroom 20BC Co-Chairs Rajeswari Appadurai, Indian Institute of Science (IISc), India Birthe Kragelund, University of Copenhagen, Denmark 2407-Plat 1:00 pm CONTEXT MATTERS IN DISORDER BASED PROTEIN COMMUNICATION.  Birthe B. Kragelund , Andreas Prestel, Nanna Wickmann, Joao Martins, Wouter Boomsma, Lasse Staby, Ruth Hendus-Altenburger, Karen Skriver 2408-Plat 1:15 pm AN ADVANCED REPLICA EXCHANGE METHOD FOR EXPLORING UNCHART- ED COMPLEX PROTEIN LANDSCAPES.  Rajeswari Appadurai , Anand 1:30 pm DIVERSE TRANSITION PATHS OF COUPLED BINDING AND FOLDING OF INTRINSICALLY DISORDERED PROTEIN PROVED BY THREE-COLOR SINGLE- MOLECULE FRET.  Jae-Yeol Kim , Hoi Sung Chung Variation on Human Health 1:00 pm - 3:00 pm, Ballroom 20D Srivastava 2409-Plat

D N

E S

D A Y

141