Biophysical Society 2020 Annual Meeting

2481-Pos Board B27 MOLECULAR DYNAMICS SIMULATIONS FOR IMPROVING CRYSTAL QUAL- ITY AND ILLUMINATING THE FUNCTION OF TASPASE1: A THERAPEUTIC TARGET.  Jacob Layton , Nirupa Nagaratnam, Rebecca J. Jernigan, Joel Schneider, Andrew Flint, Barbara Mroczkowski, Petra Fromme, Jose M. Garcia, Abhishek Singharoy 2482-Pos Board B28 STUDYING BBA PROTEIN FOLDING USING THE GRADIENT DESCENT METHOD TO MODIFY THE SIGMOID FUNCTION AS THE ORDER PARAM- ETER OF THE UMBRELLA SAMPLING METHOD. Hamed Meshkin 2483-Pos Board B29 DYNAMICS AND ENERGETICS OF LOSS-OF-FUNCTION VON WILLEBRAND FACTOR MUTANTS, DETERMINED THROUGH MOLECULAR DYNAMICS SIMULATIONS AND FREE ENERGY CALCULATIONS. Valeria Mejía-Restre- po 2484-Pos Board B30 AN ATOMIC LEVEL INTERACTIONS OF PHOSPHORYLATED TAU REPEAT WITH MICROTUBULE USING MOLECULAR MODELING APPROACH.  Vishwambhar V. Bhandare , Ambarish Kunwar 2485-Pos Board B31 Travel Awardee INVESTIGATING NOVEL HETERO-FRET BIOSENSORS FOR ENVIRON- MENTAL IONIC STRENGTH USING EXPERIMENTAL AND THEORETICAL APPROACHES. Cody P. Aplin , Robert C. Miller, Taryn M. Kay, Alessandro Cembran, Arnold J. Boersma, Ahmed A. Heikal, Erin D. Sheets 2486-Pos Board B32 DEVELOPMENT OF NEWMETHODS FOR ENHANCED CONFORMATIONAL SAMPLING OF GPCRS. Erik A. Serrano , Ravinder Abrol Protein Stability, Folding, and Chaperones II (Boards B33 - B51) 2487-Pos Board B33 MECHANISM OF THE DISULFIDE-COUPLED FOLDING OF A DE NOVO DESIGNED PROUROGUANYLIN PROTEIN. Mayu Fukutsuji , Aman L. Maha- rjan, Toi Osumi, Shigeru Shimamoto, Yuji Hidaka 2488-Pos Board B34 SINGLE-MOLECULE AFM IMAGING OF THERMALLY DENATURED FIREFLY LUCIFERASE. Dimitra Apostolidou , Piotr E. Marszalek 2489-Pos Board B35 INVESTIGATION OF MECHANICALLY LABILE TYPE III SECRETION PROTEIN EFFECTORS. Katherine E. DaPron , Morgan Fink, Marc-Andre LeBlanc, Devin T. Edwards, Thomas T. Perkins, Marcelo C. Sousa 2490-Pos Board B36 DENATURING EFFECT OF GUANIDINE HYDROHLORIDE ON AMYLOID FIBRILS. Anna I. Sulatskaya , Maksim I. Sulatsky, Olga V. Stepanenko, Olga I. Povarova, Irina M. Kuznetsova, Konstantin K. Turoverov 2491-Pos Board B37 STRUCTURAL DYNAMICS OF MAMMALIAN PRION PROTEIN CORRELATES WITH DEGREE OF SUSCEPTIBILITY TO PRION DISEASES. Patricia Soto , Alyssa L. Bursott, Hannah O. Brockman, Garrett M. Gloeb 2492-Pos Board B38 CHARACTERIZING THE INTERPLAY BETWEEN DYNAMICS AND REGULA- TION IN THE TRYPSINOGEN/TRYPSIN PROTEASE SYSTEM. Sarah Duggan 2493-Pos Board B39 EVALUATION THE PROTEIN STABILITY BY MOLECULAR DYNAMICS SIMU- LATION. Tomoshi Kameda , Kaito Kobayashi, Shin Irumagawa, Ryoichi Arai, Yutaka Saito, Takeshi Miyata, Mitsuo Umetsu

2494-Pos Board B40 USING CIRCULAR PERMUTATION TO PROBE THE ROLE OF CHAIN CON- NECTIVITY IN THE CO-TRANSLATIONAL FOLDING PROCESS OF HALO- TAG. Natalie R. Dall , Susan Marqusee 2495-Pos Board B41 INTERPRETING TRANSITION PATH TIME EXTRAPOLATION BY SINGLE MOLECULE FRET WITH MD SIMULATIONS. Grace H. Taumoefolau , Robert B. Best 2496-Pos Board B42 PH DEPENDENCE OF OLIGOMERIZATION AND FUNCTIONAL ACTIVITY OF ALPHA B CRYSTALLIN. Kashmeera D. Baboolall , Yusrah B. Kaudeer, Anne Gershenson, Patricia B. O’Hara 2497-Pos Board B43 THEORETICAL INVESTIGATIONS OF A MULTI-DOMAIN PROTEIN FOLDING UNDER CONFINEMENTS AND CROWDERS. Xiakun Chu , Jin Wang 2498-Pos Board B44 MONITORING PROTEIN FOLDING ON AND OFF THE RIBOSOME USING X- RAY FOOTPRINTING/MASS SPECTROMETRY (XF/MS). Shawn M. Costello 2499-Pos Board B45 INTRA-MOLECULAR CHAPERONE MEDIATED FOLDING OF A PEPTIDE HORMONE IN MOLECULAR EVOLUTION. Toi Osumi , Aman L. Maharjan, Mayu Fukutsuji, Shigeru Shimamoto, Yuji Hidaka 2500-Pos Board B46 IDENTIFYING THE STRUCTURAL FEATURES THAT DIFFERENTIATE CLIENT PROTEINS OF ΑB-CRYSTALLIN. Marc Sprauge-Piercy , Kyle Roskamp, Rachel W. Martin 2501-Pos Board B47 FOX01 TRANSCRIPTION FACTOR FOLDING LANDSCAPE ELUCIDATES THE ROLE OF DISEASE MUTATIONS. Dylan Novack , Lei Qian, Richard H.G. Baxter, Vincent Voelz 2502-Pos Board B48 Travel Awardee IMPROVING PERSONALIZED MEDICINE THROUGH SYSTEMATIC PROTEIN ENGINEERING OF LDH. Shamir A. Khan 2503-Pos Board B49 COMPARING STABILIZATION STRATEGIES BETWEEN ENGINEERED AND NATURALLY THERMOSTABLE PROTEINS. Catrina Nguyen , Lauren M. Yearwood, Michelle E. McCully 2504-Pos Board B50 RATIONAL MUTAGENESIS TO ENGINEER HEME STABILITY IN RECOM- BINANT HUMAN HEMOGLOBIN TO DESIGN POTENTIAL HEMOGLOBIN BASED OXYGEN CARRIER. Mohd A. Khan , Nidhi Mittal, Kajal Yadav, Sanjeev K. Yadav, Gaurav Mittal, Amit Tyagi, Suman Kundu 2505-Pos Board B51 MICROFLUIDIC DIFFUSIONAL SIZING FOR STUDYING PROTEIN-PROTEIN INTERACTIONS. Matthias M. Schneider , Tom Scheidt, Christopher M. Dobson, Tuomas P.J. Knowles Protein-Small Molecule Interactions II (Boards B52 - B71) 2506-Pos Board B52 PRINCIPLES GOVERNING ANION SELECTIVITY IN PROTEINS. Mirna Damergi , Hristina R. Zhekova, Carmen Hsieh, Sergei Y. Noskov 2507-Pos Board B53 BINDING MECHANISM OF ANTI-CANCER TARGET HSP90 AND PEPTIDE DRUG. Lisa Matsukura , Naoyuki Miyashita

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