Biophysical Society 2020 Annual Meeting

2508-Pos Board B54 ROLE OF VITRONECTIN IN THE FORMATION OF LIPID-PROTEIN AGGRE- GATES IN AGE-RELATED MACULAR DEGENERATION. Kyungsoo Shin , Lynn M. Fujimoto, James E. Kent, Andrey A. Bobkov, Fu-Yue Zeng, Ian Pass, Francesca M. Marassi 2509-Pos Board B55 THE EFFECTS OF A SMALL-MOLECULE INHIBITOR ON CDC42, ITS MUTANT AND ITS INTERACTION WITH EFFECTOR PROTEINS. Djamali Muhoza 2510-Pos Board B56 A COMPARATIVE STUDY TO DETERMINE SUBSTRATE-BINDING PATTERN IN EICOSANOID-GENERATING ENZYMES BY COMPUTATIONAL MAP- PING.  Inseok Song 2511-Pos Board B57 EXPERIMENTAL MEASURE OF SOLVATION ENERGY FROMMODEL CRYPTOPHANE-RUBIDIUM BINDING REACTION. Daryl K. Eggers , Sherry Fu, Dominic V. Ngo, Elizabeth H. Vuomg, Thierry Brotin 2512-Pos Board B58 DEVELOPMENT OF NOVEL SMALL-MOLECULE THERAPIES FOR THE TREATMENT OF HEART FAILURE. Eli Antonio Alonso Fernandez de Gortari 2513-Pos Board B59 CHARACTERIZING THE INFLUENCE OF TWO SMALL MOLECULE TARGETS TOWARDS THE RAS-RELATED PROTEIN CDC42. Djamali Muhoza, Emilio Duverna, Alix Montoya-Beltrand, Paul D. Adams 2514-Pos Board B60 UNDERSTANDING EBOLA VIRUS PROTEIN SHAPE SHIFTING FOR DRUG DESIGN. Matthew A. Cruz 2515-Pos Board B61 CHARACTERIZATION AND CONTROL OVER PROTEIN MULTIMERIZATION INDUCED BY PORPHYRINS. Samuel D. Fontaine 2516-Pos Board B62 PHOTO-CONTROL OF RAS FUNCTION USING PEPTIDE INHIBITOR MODI- FIED WITH AZOBENZENE DERIVATIVE. Nobuyuki Nishibe , Kenichi Taii, Toshio Nagashima, Toshio Yamazaki, Kazunori Kondoh, Shinsaku Maruta 2517-Pos Board B63 IMPACT OF THE INTERNAL DISULFIDE BOND ON THE LIGAND MIGRA- TION IN GLOBIN X. Ruipeng Lei , Maria J. Santiago Estevez, Manuel Picon, Isa Sabir, Valerie Derrien, Sophie Bernad, Jaroslava Miksovska 2518-Pos Board B64 ANALYSIS OF THE LIFETIME OF THE FIMH CATCH BOND UNDER FORCE. Laura A. Carlucci , Wendy E. Thomas 2519-Pos Board B65 PREDICTION OF FREE ENERGY BY DOCKING SIMULATION USING INTER- FRAGMENT INTERACTION ENERGIES. Hirofumi Fuji , Norihito Kawashita 2520-Pos Board B66 INVISIBLE STATE OF MDMX AND DESIGN OF ITS INHIBITORS. Xiyao Cheng , Huili Liu, Yongqi Huang, Zhengding Su 2521-Pos Board B67 MULTISITE BINDING IN TWO AND THREE DIMENSIONS.  Irina V. Gopich 2522-Pos Board B68 A NOVEL NANOBEAD-BASED SINGLE-MOLECULE PULL-DOWN FOR CELL POPULATIONS AND SINGLE CELLS. Qirui Zhao , Yusheng Shen, Fang Tian, Xiaofen LI, Levent YOBAS, Hyokeun Park, Pingbo Huang

2523-Pos Board B69 DRUGGING PROTEIN-PROTEIN INTERFACES OF A SUPRAMOLECULAR ASSEMBLY AS A MEANS TO OVERCOME RESISTANCE TO ACTIVE SITE THYMIDYLATE SYNTHASE INHIBITORS. Tigran M. Abramyan , Alexander Tropsha, Andrew L. Lee, Paul J. Sapienza 2524-Pos Board B70 BIOPHYSICAL CHARACTERIZATION OF THE BINDING OF HRSV M2-1 PRO- TEIN TO RNA AND SOLASODINE. Vitor BrassolattiMachado , Giovana Cavenaghi Guimarães, Marcelo Andrés Fossey, Ícaro Putinhon Caruso, Fatima Pereira de Souza 2525-Pos Board B71 CONSTRUCTING GPR6 HOMOLOGY MODEL, DOCKING STUDIES AND DRUG DESIGN.  Israa Isawi , Paula Morales, Dow P. Hurst, Diane L. Lynch, Patricia H. Reggio Protein Assemblies II (Boards B72 - B83) 2526-Pos Board B72 DIRECTED EVOLUTION OF STRUCTURAL PROTEINS USING A HIGH THROUGHPUT APPROACH. Melik C. Demirel 2527-Pos Board B73 COARSE-GRAINED MOLECULAR DYNAMICS SIMULATIONS OF TRIM5AL- PHA SELF-ASSEMBLY AND RESTRICTION OF HIV. Alvin Yu , Katarzyna Skorupka, Alexander Pak, Barbie K. Ganser-Pornillos, Owen Pornillos, Gregory A. Voth 2528-Pos Board B74 PROTEIN DOCKING REFINEMENT WITH SYSTEMATIC CONFORMATIONAL SEARCH - APPLICATION TO MODELS INSIDE THE DOCKING FUN- NEL. Taras Dauzhenka , Ivan Anishchenko, Petras Kundrotas, Ilya Vakser 2529-Pos Board B75 DYNAMIC INTERROGATION OF A VIRAL DNA PACKAGING MOTOR COMPLEX.  Joshua Pajak , Erik Dill, Mark A. White, Paul Jardine, Marc C. Morais, Gaurav Arya 2530-Pos Board B76 INTERFACEA: OPEN-SOURCE LIBRARY FOR PROTEIN INTERFACE ANALY- SIS.  João Pedro Garcia Lopes Maia Rodrigues , Michael Levitt 2531-Pos Board B77 Travel Awardee BREAKING THE SYMMETRY OF PROTEIN ASSEMBLIES: STRUCTURAL FLEXIBILITY AS A DE NOVO DESIGN PRINCIPLE. Alena Khmelinskaia , Andrew J. Borst, Yang Hsia, Quinton Dowling, David Veesler, Neil P. King 2532-Pos Board B78 UNDERSTANDING SEPARATION OF TIME SCALES IN BACTERIAL PROTEA- SOME ASSEMBLY. Pushpa Itagi , Anupama Kante, Anjana Suppahia, Jeroen Roelfs, Eric J. Deeds 2533-Pos Board B79 EVALUATING SELF-ASSEMBLY PROPENSITY OF TETRA-PEPTIDE USING MD AND MACHINE LEARNING. Yoichi Kurumida , Keisuke Ikeda, Yusuke Nakamichi, Kaito Kobayashi, Yutaka Saito, Tomoshi Kameda 2534-Pos Board B80 ON NON-MONOTONIC DEPENDENCE OF PHASE SEPARATION PROPER- TIES ON MOLECULAR INTERACTION PARAMETERS. George M. Thurston , Douglas L. Hayden, Giuseppe Foffi, David S. Ross, John F. Hamilton 2535-Pos Board B81 MODELING SYNTHESIZED PROTEIN MEGAMOLECULES: STRUCTURE, DY- NAMICS, AND FUNCTIONS. Peng He , Josh Zuchniarz, Shengwang Zhou, Justin Modica, Sonali Dhindwal, Ying Li, Gregory A. Voth, Milan Mrksich, Vinayak P. Dravid, Benoit Roux

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