Biophysical Society 2020 Annual Meeting

2629-Pos Board B175 MAP OF GENETICALLY CONSTRAINED REGIONS IN HUMAN INTRINSICALLY DISORDERED PROTEINS. Zaara Rifat, Shehab Ahmed, Arthur J. Campbell, A. Keith Dunker, Sohel Rahman, Sumaiya Iqbal 2630-Pos Board B176 DESTABILIZING BETA SHEET PEPTIDES FROM THE HYDROPHOBIC CORE OF ALPHA SYNUCLEIN. Sarah A. Petty , Michael J. Calceterra, MatthewW. Fernandez, Christopher G. Fernandez, Sophia A. Von Fedak 2631-Pos Board B177 MICROSCOPIC MODEL OF A BIOLOGICAL CONDENSATE. Swan Htun , Kumar Sarthak, Han-Yi Chou 2632-Pos Board B178 STUDYING RNA MODULATED PROTEIN LIQUID-LIQUID PHASE SEPARA- TION USING COARSE-GRAINED MODELS. Roshan M Regy , Gregory L. Dignon, Youngchan Kim, Jeetain Mittal 2633-Pos Board B179 ALPHA-SYNUCLEIN MODULATES STIMULATED EXOCYTOSIS AND BINDS TO MITOCHONDRIA WITH FUNCTIONAL CONSEQUENCES. Meraj Ramezani , Tapojyoti Das, David A. Holowka, David Eliezer, Barbara A. Baird 2634-Pos Board B180 COMPUTATIONAL CHARACHTERIZATION OF FUS DISASSEMBLY BY KAPB2. Genevieve Kunkel 2635-Pos Board B181 FORCE FIELD REFINEMENT BASED ON HIGH RESOLUTION PROTEIN STRUCTURES. Robert Best 2636-Pos Board B182 BASIN MAPPING METHOD FOR EXTRACTING COMPARATIVE ASSESS- MENTS OF PROTEIN PHASE BEHAVIOR FROM IN VIVO MEASUREMENTS.  Jared M. Lalmansingh , Ammon E. Posey, Tejbir Kandola, Randal Half- mann, Rohit V. Pappu 2637-Pos Board B183 DESTABILIZATION AND RESISTING GROWTH OF ALPHA-SYNUCLEIN FIBRIL BY SYNUCLEAN-D. Soumyo Sen , Emad Tajkhorshid 2638-Pos Board B184 ROLE OF INTERACTION MODULARITY IN GOVERNING PHASE BEHAVIOR, STRUCTURE AND DYNAMICS OF TERNARY PROTEIN-RNA CONDEN- SATES. Taranpreet Kaur , Priya R. Banerjee 2639-Pos Board B185 STRUCTURAL STUDIES OF AMYLOIDOGENIC PEPTIDES WITH CATIONIC GEMINI IMIDAZOLIUM SURFACTANTS.  Julia Ludwiczak , Maciej Kozak, Aneta Szymanska, Kosma Szutkowski, Michalina M. Wilkowska 2640-Pos Board B186 NPM1 EXHIBITS STRUCTURAL AND DYNAMIC HETEROGENEITY UPON PHASE SEPARATION WITH THE TUMOR SUPPRESSOR ARF. Eric B. Gibbs , Barbara Perrone, Aila Hassan, Rainer Kümmerle, Richard Kriwacki 2641-Pos Board B187 Travel Awardee ALPHA-SYNUCLEIN DETECTS AND PREFERENTIALLY BINDS TO OSMOTI- CALLY TENSE SYNAPTIC VESICLE-LIKE MEMBRANES. Peter J. Chung 2642-Pos Board B188 ENERGETICS OF Π-Π INTERACTIONS IMPLICATED IN LIQUID-LIQUID PHASE SEPARATION. Andrea Guljas , Robert M. Vernon, Julie D. Forman-Kay, Régis Pomès 2643-Pos Board B189 HEURISTICS FOR THE EFFECTS OF SEQUENCE AND CONFORMATIONAL CONTEXTS ON PK A VALUES OF IONIZABLE RESIDUES INFERRED FROM Q -CANONICAL MONTE CARLO SIMULATIONS. Martin J. Fossat , Ammon E. Posey, Rohit V. Pappu

2617-Pos Board B163 A COMPUTATIONAL STUDY OF THE EFFECT OF PROTONATION STATES ON THE N79D MUTATION IN UBC13. Robert W. Gardner 2618-Pos Board B164 CHARACTERZING THE AUXILIARY NUCLEOTIDE BINDING SITES IN RECBCD DNA HELICASE, TOWARDS DECIPHERING THEIR FUNCTIONAL ROLE. Siv- asubramanyan Mangapuram Venkata , Rani Zananiri, Vera Gaydar, Oded Kleifeld, Ariel Kaplan, Arnon Henn 2619-Pos Board B165 MECHANISM OF DEGRADATION OF HISTATIN 5 PEPTIDE BY SECRETED ASPARTIC PROTEASES (SAPS) OF C. ALBICANS . Mahdi Ghorbani , Jeffery B. Klauda, Bernard R. Brooks 2620-Pos Board B166 REAL-TIME MEASUREMENT OF PHOSPHATASE ACTIVITY DURING PROTEO- LYTIC DIGESTION BY LYSYL ENDOPEPTIDASE USING HIGH PRESSURE OPTI- CAL SPECTROSCOPY. Gary B. Smejkal , Vera Gross, Nicole Cutri, Alexander Lazarev 2621-Pos Board B167 WATER AS AN ESSENTIAL COFACTOR FOR ALL ENZYMES. Pedro L. Muino , Patrik R. Callis 2622-Pos Board B168 A HIGH-THROUGHPUT ASSAY PLATFORM FOR NEXT-GENERATION MECHA- NISTIC ENZYMOLOGY AND APPLICATIONS. Craig J. Markin , Daniel A. Mokhtari, Fanny Sunden, Mason J. Appel, Dan M. Herschlag, Polly Fordyce 2623-Pos Board B169 Travel Awardee IMPAIRED AUTOINHIBITION OF PROTEIN KINASE CΓ IN SPINOCEREBEL- LAR ATAXIA TYPE 14. Caila A. Pilo , Maya T. Kunkel, An-Angela N. Van, Evan K. Kobori, Alexandr P. Kornev, Cheryl Longman, George Gorrie, Susan S. Taylor, Alexandra C. Newton 2624-Pos Board B170 DISTAL RESIDUES AND ENZYME ACTIVITY: IMPLICATIONS FOR PERSONAL- IZED MEDICINE. Lisa Ngu, Jenifer N. Winters, Lee Makowski, Penny J. Beun- ing, Mary Jo Ondrechen Intrinsically Disordered Proteins (IDP) and Aggregates IV (Boards B171 - B196) 2625-Pos Board B171 MEMBRANE ASSOCIATION OF THE INTRINSICALLY DISORDERED N-TERMI- NAL REGION OF CHIZ. Alan Hicks , Cristian A. Escobar, Timothy A. Cross, Huan-Xiang Zhou 2626-Pos Board B172 UNCOVERING THE STRUCTURAL BASIS FOR THE MECHANICAL PROPER- TIES OF ELASTIN. Lamia Hossain , Ananya Srivastava, Quang Huynh, Régis Pomès 2627-Pos Board B173 INTRINSICALLY UNFOLDED ALPHA-C REGION OF FIBRINOGEN IS MAJOR CONTRIBUTOR TO MECHANICAL STRENGTH OF FIBRIN FIBERS. Ali Daraei, Taylor C. Dement, Nathan E. Hudson, Martin Guthold 2628-Pos Board B174 DYNAMICS IN NATURAL AND DESIGNED ELASTINS AND THEIR RELATION TO ELASTIC FIBER STRUCTURE AND RECOIL. Ma. Faye Charmagne Carvajal, Jonathan Preston, Nour Jamhawi, Christo Vairamon, Dernae Rowe, Joel Bresland, James Aramini, Thomas Michael Sabo, Richard Wittebort, Ronald Koder

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