Biophysical Society 2020 Annual Meeting

2777-Pos Board B323 RYR2 INHIBITION BY FLECAINIDE DETERMINES ANTIARRHYTHMIC ACTIV- ITY IN CPVT. Dmytro O. Kryshtal , Daniel J. Blackwell, Abbigail N. Smith, Suzanne M. Batiste, Jeffrey N. Johnston, Bjorn C. Knollmann 2778-Pos Board B324 A CRYO-EM BASED STUDY OF AN EQUIVALENT N TERMINAL DOMAIN MUTATION IN SKELETAL AND CARDIAC RYANODINE RECEPTOR (RYR).  Kavita A. Iyer , Yifan Hu, Ashok R. Nayak, Nagomi Kurebayashi, Takashi Murayama, Montserrat Samso 2779-Pos Board B325 EFFECTS OF CONFOCAL MODALITIES AND DETECTORS IN HIGH-SPEED RECORDING OF CA 2+ SPARKS IN CARDIOMYOCYTES. Qinghai Tian , Peter Lipp 2780-Pos Board B326 THE ROLE OF NAADP-MEDIATED ENDO-LYSOSOMAL CALCIUM RELEASE IN THE CARDIAC ATRIA. Rebecca A. Capel, Razik Mu-u-Min, Daniel Aston, Margarida Ruas, Helen Christian, Antony Galione, Derek A. Terrar, Rebecca A.B. Burton 2781-Pos Board B327 THE MOLECULAR BASIS FOR SOCE REGULATION BY SARAF. Anna Meshcheriakova , Christopher Kimberlin, Raz Palty, Izhar Karbat, Daniel L. Minor, Eitan Reuveny 2782-Pos Board B328 HIGH-THROUGHPUT SCREENING YIELDS ALLOSTERIC INHIBITORS OF LEAKY RYRS FOR THERAPEUTIC DEVELOPMENT. Robyn T. Rebbeck , Gabrielle M. Evans, Kaja Rozman, Jacob A. Schwarz, Michael C. Wold, Marzena Baran, Courtney C. Aldrich, Donald M. Bers, David D. Thomas, Razvan L. Cornea 2783-Pos Board B329 MECHANISMS OF SUBCELLULAR SPATIALLY DISCORDANT CALCIUM ALTERNANS IN CARDIAC MYOCYTES. Zhen Song , Zhilin Qu 2784-Pos Board B330 Travel Awardee LATE CA 2+ SPARK ARRHYTHMOGENESIS IN FAILING CARDIAC MYO- CYTES. Ewan D. Fowler , Nan Wang, Jules C. Hancox, Mark B. Cannell Cardiac, Smooth, and Skeletal Muscle Electrophysiology II (Boards B331 - B345) 2785-Pos Board B331 CRISPRI ION CHANNEL GENE MODULATION IN HUMAN IPSC-CARDIOMY- OCYTES.  Julie L. Han , Emilia Entcheva 2786-Pos Board B332 PROBING THE TIMELINE OF INTEGRATION BETWEEN THREE-DIMEN- SIONAL “SPARK-CELL” SPHEROIDS AND HUMAN CARDIAC TISSUE.  Christianne Chua , Weizhen Li, Julie Han, Emilia Entcheva 2787-Pos Board B333 THE ROLE OF IL-1Β ON ATRIAL FIBRILLATION PHYSIOPATHOLOGY. Oscar Moreno-Loaiza , Ainhoa Rodriguez de Yurre Guirao, Narendra Vera- Nuñez, Ariel L. Escobar, Emiliano Medei 2788-Pos Board B334 Travel Awardee AUTOMATED HIGH-THROUGHPUT PATCH CLAMP AND MODELLING TO CAPTURE HERG KINETICS AND TEMPERATURE DEPENDENCE USING OPTIMISED VOLTAGE PROTOCOLS. Chon Lok Lei , Michael Clerx, David J. Gavaghan, Johannes Stiehler, Liudmila Polonchuk, Ken Wang, Gary R. Mirams

2789-Pos Board B335 UPREGULATION OF THE MAGUK SAP97 ENHANCES PROTEIN EXPRES- SION IN STEM CELL DERIVED MYOCYTES. Tamirat Ali, Jeffery Creech, Andre Monteiro Da Rocha, Todd J. Herron, Justus M. Anumonwo 2790-Pos Board B336 UNIDIRECTIONAL BLOCK DEMONSTRATED ON VENTRICULAR MONOLAY- ERS EXPRESSING CHANNELRHODOPSIN-2 USING OPTOGENETICS.  José Miguel Romero Sepúlveda , Alvin Shrier, Gil Bub 2791-Pos Board B337 COMBINING PHYSIOLOGICAL RELEVANCE AND THROUGHPUT FOR IN VITRO CARDIAC CONTRACTILITY MEASUREMENT. Ronald Knox , Andrea Bruggemann, Matthias Gossmann, Ulrich Thomas, András Horváth, Elena Dragicevic, Sonja Stoelzle-Feix, Niels Fertig, Alexander Jung, Alex- ander H. Raman, Manfred Staat, Peter Linder 2792-Pos Board B338 AUTOMATED PATCH CLAMP SYSTEM INTRODUCING SIMULATED IK1 INTO STEM CELL-DERIVED CARDIOMYOCYTES USING DYNAMIC CLAMP. George O. Okeyo , András Horváth, Nadine Becker, Alan Fabbri, Christian Grad, Michael George, Teun P. de Boer, Niels Fertig 2793-Pos Board B339 THE BISTABLE RESTING POTENTIAL OF SKELETAL MUSCLE IN HYPOKALE- MIC PERIODIC PARALYSIS. Marino G. Di Franco, Steve C. Cannon 2794-Pos Board B340 LOW-NOISE FLUORESCENT INFRARED DETECTION OF SINGLE-CELL CAR- DIAC ACTION POTENTIALS. Anthony Costantino , Brian K. Panama, Mark W. Nowak, Randall L. Rasmusson, Glenna Bett 2795-Pos Board B341 NATRIURETIC PEPTIDE RECEPTOR-C MITIGATES ANGIOTENSIN II INDUCED FIBROSIS IN THE ATRIA AND SINOATRIAL NODE. Martin Mack- asey , Hailey J. Jansen, Motahareh Moghtadaei, Robert A. Rose 2796-Pos Board B342 CHRONIC HEMODYNAMIC OVERLOAD OF THE ATRIA IS AN IMPORTANT FACTOR FOR SHEAR SIGNALING REMODELING IN RAT HEARTS. Qui A. Le , Joon-Chul Kim, Berihun D. Mihiretu, Sun-Hee Woo 2797-Pos Board B343 Travel Awardee POST-PRANDIAL INOTROPIC RESPONSE IN PYTHON CARDIOMYOCYTES IS SUPPORTED BY DISTINCT METABOLIC ADAPTATION. Claudia Crocini , Kathleen C. Woulfe, Leslie A. Leinwand 2798-Pos Board B344 CARDIOPROTECTIVE EFFECTS OF ROTIGAPTIDE ARE DEPENDENT ON PERFUSATE IONIC COMPOSITION DURING ISCHEMIA/REPERFU- SION. Gregory S. Hoeker , Steven Poelzing 2799-Pos Board B345 QUANTIFYING HYPOXIA IN HUMAN IPS-CARDIOMYOCYTES UNDER OP- TOGENETIC PACING. Wei Liu , WEIZHEN LI, Julie Han, Emilia Entcheva

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Intracellular Transport (Boards B346 - B353)

2800-Pos Board B346 SINGLE-MOLECULE TRACKING REVEALS COMPLEX MOTILITY OF TRANSMEMBRANE PROTEINS IN THE CHEMOSENSORY CILIA OF C. EL- EGANS . Jaap van Krugten, Noemie B. Danne, Erwin J. Peterman 2801-Pos Board B347 ORGANELLE STRUCTURAL FEATURES CAN ACCELERATE DIFFUSIVE TRANSPORT AND REACTION RATES. Aidan I. Brown , Elena F. Koslover

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