Biophysical Society 2020 Annual Meeting

2828-Pos Board B374 IDENTIFICATION OF A NOVEL GAIN-OF-FUNCTION SODIUM CHANNEL B2 SUBUNIT MUTATION IN SMALL FIBER NEUROPATHY. Matthew Alsaloum , Peng Zhao, Monique M. Gerrits, Rowida Almomani, Janneke Hoeijmak- ers, Maurice Sopacua, Giuseppe Lauria, Catharina G. Faber, Sulayman Dib-Hajj, Stephen G. Waxman 2829-Pos Board B375 FUNCTIONAL UNCOUPLING OF PAIN-LINKED NAV1.7/A1632E DIMERS PARTLY RESCUES ITS PAIN-CAUSING PHENOTYPE. Annika Ruehlmann , Jannis Körner, Nikolay Bebrivenski, Silvia Detro-Dassen, Petra Hautv- ast, Carène Benasolo, Jannis Meents, Jan-Philipp Machtens, Günther Schmalzing, Angelika Lampert 2830-Pos Board B376 EFFICIENT AND HIGHLY SCALABLE MECHANISTIC CHARACTERIZATION OF ION CHANNEL FUNCTION IN DRUG DISCOVERY. Tianbo Li , Martin Ginkel, Ada Yee, Leigh Foster, Renee Emkey, Jun Chen, Stephan Heyse, Stephan Steigele 2831-Pos Board B377 PROBING ALTERED CALMODULIN INTERACTIONS IN SODIUM CHAN- NELOPATHIES USING FLOW-CYTOMETRIC FRET.  Johanna Diaz , Khadija Hanif, Viviana Laines, Nourdine Chakouri, Manu B. Johny 2832-Pos Board B378 RAPIDLY ASSAYING VOLTAGE-GATED SODIUM CHANNELS USING LIGHT- INDUCED ACTION POTENTIALS AND FLUORESCENT RECORDINGS OF THE MEMBRANE POTENTIAL IN AN INSTRUMENT WITH A NOVEL DETECTOR ARRAY. Joerg Oestreich, Stephen S. Smith , Jay Trautman, Andrew L. Blatz Ligand-gated Channels (Boards B379 - B413) 2833-Pos Board B379 TRANSITION PATHWAY FOR ACTIVATION OF LIGAND-GATED ION CHAN- NELS AND THE ROLE OF CHOLESTEROL. Sunny Hwang , Christophe J. Chipot, Emad Tajkhorshid 2834-Pos Board B380 POLYUNSATURATED FATTY ACID REGULATION OF THE ACID-SENSING ION CHANNELS. Robert C. Klipp , John R. Bankston 2835-Pos Board B381 THE BINDING SITE OF TETS IN THE PORE OF THE Α2B3Γ2L GABA-A RE- CEPTOR. Brandon Pressly , Heike Wulff, Ruth Lee 2836-Pos Board B382 SCREENING OF EPILEPSY-LINKED GABAA RECEPTOR MUTANTS FOR AS- SEMBLY DEFECTS. Sarah Ziemons, Guenther Schmalzing 2837-Pos Board B383 A RE-EVALUATION OF GAIN-OF-FUNCTION DISEASE-ASSOCIATED MUTA- TIONS IN NMDA RECEPTORS. Gary J. Iacobucci 2838-Pos Board B384 DYNAMICAL MECHANISMS OF GLUTAMATE RECEPTOR GATING AND SUB-CONDUCTANCE. Maria G. Kurnikova , Serzhan Sakipov, Christopher Kottke, Chamali Narangoda, Jessica Scaranto 2839-Pos Board B385 MOLECULAR MECHANISM OF PH REGULATION ON TMEM16F LIPID SCRAMBLASE AND ION CHANNEL. Pengfei Liang , Trieu P. Le, Son C. Le, Huanghe Yang 2840-Pos Board B386 LIFE IN THE FAST LANE- BINDING TO GLUTAMATE RECEPTORS. Remy Yovanno, Tyler J. Wied, Alvin Yu, Hector P. Salazar, Andrew J. Plested, Albert Y. Lau

2841-Pos Board B387 USING A NETWORK OF SINGLE SITE SPECIFIC MUTATIONS AND CROSS- LINKING MASS SPECTROMETRY (CXMS) TO REFINE THE STRUCTURE AND DYNAMICS OF THE HUMAN ALPHA 1 GLYCINE RECEPTOR (GLYR). Kayce A. Tomcho , Hannah E. Gering, Amanda Pellegrino, David J. Lapinsky, Michael Cascio 2842-Pos Board B388 CRYO-EM STRUCTURE DETERMINATION AND MODEL FITTING OF THE PROTON-GATED LIGAND-GATED ION CHANNEL GLIC AT MULTIPLE PH STATES. Urska Rovsnik, Victoria Lim, Christian Blau, Rebecca J. Howard, Erik Lindahl 2843-Pos Board B389 FUNCTIONAL RECONSTITUTION OF THE 5-HT 3 RECEPTOR. Uriel López Sánchez , Eleftherios Zarkadas, Guy Schoehn, Hugues Nury 2844-Pos Board B390 PHARMACOLOGICAL CHARACTERIZATION OF THE ZINC-ACTIVATED CHANNEL: A CYS-LOOP RECEPTOR GATED BY ZN 2+ , CU 2+ AND PRO- TONS. Nawid Madjroh , Anders A. Jensen, Paul A. Davies 2845-Pos Board B391 MECHANISM AND BINDING SITE OF THE ASIC1A-BIG DYNORPHIN INTERACTION. Christian B. Borg, Nina Braun , Stephanie A. Heusser, Yasmin Bay, Daniel Weis, Iacopo Galleano, Camilla Lund, Weihua Tian, Linda M. Haugaard-Kedström, Eric P. Bennett, Timothy Lynagh, Kristian Strømgaard, Jacob Andersen, Stephan A. Pless 2846-Pos Board B392 POINT MUTATIONS OF P2X7 RECEPTORS. Hannah Dentler, Manuela Klap- perstück, Guenther Schmalzing, Fritz Markwardt 2847-Pos Board B393 CRYO-EM STRUCTURE OF THE Α1Β2Γ2 GABA A RECEPTOR IN A LIPIDIC ENVIRONMENT.  Jeong Joo Kim , Anant Gharpure, Jinfeng Teng, Shaotong Zhu, Colleen M. Noviello, Richard M. Walsh, Ryan E. Hibbs 2848-Pos Board B394 MECHANISM OF CALCIUM GATING AND INACTIVATION IN A POTASSIUM CHANNEL. Chen Fan , Nattakan Sukomon, Jan Rheinberger, Crina M. Board B395 CHARACTERIZATION OF AMINO ACID SUBSTITUTIONS IN THE PUTATIVE BINDING SITE OF BUPROPION IN GLIC. Dubem Onyejegbu , Jessica Shep- herd, Elham Pirayesh, Akash Pandhare, Zackary R. Gallardo, Michaela Jansen 2850-Pos Board B396 Travel Awardee STOICHIOMETRY OF ACID-SENSING ION CHANNEL (ASIC) PHARMACOL- OGY. Matthew L. Rook , David M. MacLean 2851-Pos Board B397 STRUCTURAL INSIGHTS INTO THE CALCIUM/CALMODULIN DEPENDENT INACTIVATION OF N-METHYL-D-ASPARTATE (NMDA) RECEPTORS. Nidhi Kaur Bhatia , Elisa Carrillo, Ryan J. Durham, Vladmir Berka, Vasanthi Jayaraman 2852-Pos Board B398 MOLECULAR DYNAMICS SIMULATION OF LIGAND BINDING AND ION PERMEATION IN A GANGLIONIC NICOTINIC RECEPTOR. Yuxuan Zhuang , Anant Gharpure, Ryan E. Hibbs, Rebecca J. Howard, Erik R. Lindahl 2853-Pos Board B399 PROBABILITY OF OPENING DURING RECOVERY FROM ACHR DESENSITI- ZATION. Radhakrishnan Gnanasambandam , Anthony Auerbach Nimigean 2849-Pos

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