Biophysical Society 2020 Annual Meeting

2854-Pos Board B400 PROTEIN-PROTEIN INTERACTIONS OF HUMAN P2X7 IN MICROGLIA AND HUMAN ASIC1A IN KIDNEY CELLS. Mette H. Poulsen, Svetlana R. Maurya, Johann Sigurdsson, Alicia Lundby, Stephan A. Pless 2855-Pos Board B401 DICATIONIC, TRICATIONIC AND TETRACATIONIC SURFACTANTS AS TRANSGENE CARRIERS - COMPARISON OF THEIR ABILITY TO SIRNA BINDING. Weronika J. Andrzejewska , Michalina M. Wilkowska, Andrzej Skrzypczak, Anna Woźniak, Barbara Peplińska, Maciej Kozak 2856-Pos Board B402 ALLOSTERIC GATING DETERMINANTS IN THE TRANSMEMBRANE DOMAIN OF PENTAMERIC LIGAND-GATED ION CHANNELS. Rebecca J. Howard , Yuxuan Zhuang, Stephanie A. Heusser, Cathrine C. Bergh, Urska Rovsnik, Laura Orellana, Erik Lindahl 2857-Pos Board B403 UNDERSTANDING THE MECHANISM OF AGONIST EFFICACY IN A FULL- LENGTH GLUK2/K5 USING SINGLE MOLECULE FRET. Nabina Paudyal , Douglas B. Litwin, Vladmir Berka, Elisa Carrillo, Vasanthi Jayaraman 2858-Pos Board B404 MOLECULAR RECOGNITION OF NEONICOTINOID INSECTICIDES BY HON- EYBEE NICOTINIC RECEPTORS AND ACHBP HOMOLOGUES. Chris Ulens , Quinty Bisseling, Marijke Brams, Aujan Mehregan, Genevieve L. Evans, Diletta Pasini, Hester Beard, Steven Verhelst, Alexander Fish, Sofie van Dorst, Kumiko Kambara, Daniel Bertrand 2859-Pos Board B405 LOWERING EXCITOTOXICITY AND STABILIZING SERIAL ACTIVATION OF NMDA RECEPTORS IN AUTOMATED PATCH CLAMP ASSAYS. Ali Yehia, Alexandra Stevens 2860-Pos Board B406 A MATHEMATICAL MODEL FOR LIGAND POTENCY IN THE HCN2 CHAN- NEL. Leo Ng, Meiying Zhuang, Filip Van Petegem, Yue-Xian Li, Eric Accili 2861-Pos Board B407 IDENTIFICATION OF THE BINDING SITE OF BUPROPION ON SEROTONIN TYPE 3A RECEPTORS.  Jessica Shepherd , Dubem Onyejegbu, Antonia Stuebler, Zackary Gallardo, Chris Hornback, Michaela Jansen 2862-Pos Board B408 HEARING LOSS MUTATIONS ALTER THE FUNCTIONAL PROPERTIES OF HUMAN P2X2 RECEPTOR CHANNELS THROUGH DISTINCT MECHA- NISMS. Benjamin I. George, Kenton Swartz, Mufeng Li 2863-Pos Board B409 FUNCTIONAL CHARACTERIZATION OF ION CHANNELS EXPRESSED IN EUKARYOTIC CELL-FREE SYSTEMS USING LIPID BILAYER ARRAYS.  Ekaterina Zaitseva , Srujan Dondapati, Jeffrey Schloßhauer, Anne Ze- mella, Priyavathi Dhandapani, Stefan Kubick, Gerhard Baaken 2864-Pos Board B410 AGONIST SELECTIVITY AND ION PERMEATION IN THE Α3Β4 GANGLIONIC NICOTINIC RECEPTOR. Anant Gharpure , Jinfeng Teng, Yuxuan Zhuang, Colleen M. Noviello, Richard M. Walsh, Rico Cabuco, Rebecca J. Howard, Nurulain Zaveri, Erik R. Lindahl, Ryan E. Hibbs 2865-Pos Board B411 ROLE OF CONFORMATIONAL DYNAMICS IN NMDA RECEPTOR NEGA- TIVE COOPERATIVITY. Ryan J. Durham , Nabina Paudyal, Elisa Carrillo, David M. MacLean, Vladmir Berka, DrewM. Dolino, Nidhi Kaur Bhatia, Alemayehu A. Gorfe, Vasanthi Jayaraman 2866-Pos Board B412 MOLECULAR EVOLUTION OF PLANT GLUTAMATE RECEPTORS. Alex A. Simon , Juan Barbosa-Caro, Jose Feijo, Erwan Michard

2867-Pos Board B413 MEASURING INTERACTIONS BETWEEN THE INTRACELLULAR DOMAINS OF THE ACID-SENSING ION CHANNEL. Megan M. Cullinan , John R. Bankston

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Ion Channels, Pharmacology, and Disease II (Boards B414 - B436)

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2868-Pos Board B414 ION SELECTIVE PENTAMERIC PORE FORMATION BY EBOLA VIRUS DELTA PEPTIDE. Rudramani Pokhrel , Elumalai Pavadai, Bernard Gerstman, Prem P. Chapagain 2869-Pos Board B415 INTRACELLULAR RECORDING USING TRANSMEMBRANE CONDUCTIVE NANOPARTICLES. Mitsuyoshi L. Saito 2870-Pos Board B416 STRUCTURAL MODELING OF ION CHANNEL - SMALL MOLECULE INTER- ACTIONS USING ROSETTA’S GALIGANDDOCK. Brandon J. Harris , Phuong T. Nguyen, Vladimir Yarov-Yarovoy 2871-Pos Board B417 BINDING WITHOUT BLOCK. AN ANALYSIS OF AMANTADINE AND RIMANTADINE BLOCK OF THE INFLUENZA M2 S31N CHANNEL. Kelly L. McGuire , David D. Busath 2872-Pos Board B418 SELECTIVE INHIBITION OF DIFFERENT ISOFORMS OF CONNEXIN HEMI- CHANNELS BY NEW AMINOGLYCOSIDES. Abbey Kjellgren , Mariana C. Fiori, Madher N. AlFindee, Yagya P. Subedi, Srinivasan Krishnan, Cheng- Wei T. Chang, Guillermo A. Altenberg 2873-Pos Board B419 Travel Awardee CYSLT1 RECEPTOR ANTAGONISTS PRANLUKAST AND ZAFIRLUKAST INHIBIT LRRC8-MEDIATED VOLUME REGULATED ANION CHANNELS INDEPENDENTLY OF THE RECEPTOR. Eric E. Figueroa , Jerod S. Denton 2874-Pos Board B420 ALTERATION OF MEMBRANE CHOLESTEROL CONTENT PLAYS A KEY ROLE IN REGULATION OF CFTR CHANNEL ACTIVITY. Guiying Cui , Kirsten A. Cot- trill, Kerry M. Strickland, Barry R. Imhoff, Nael A. McCarty 2875-Pos Board B421 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE VARIATIONS IN CODING AND NONCODING REGIONS IN CONGENITAL BILATERAL ABSENCE OF THE VAS DEFERENS DEPENDENT INFERTIL- ITY. Semire Uzun Göçmen , Klaus Wagner, Sina Gökçe 2876-Pos Board B422 ANTIEPILEPTIC DRUG ETHOSUXIMIDE MAY REGULATE ABSENCE SEI- ZURES THROUGH DIFFERENT ION CHANNELS. Boris Shalomov , Shoham Dabbah, Nathan Dascal 2877-Pos Board B423 PHARMACOLOGICAL SENSITIVITY OF KCNQ & GIRK K + CHANNELS AND CA V CA 2+ CHANNELS TO COMMONLY-USED DRUGS. Victor de la Rosa, Mark S. Shapiro 2878-Pos Board B424 POTASSIUM CHANNEL ACTIVITY UNVEILS CANCER VULNERABILITY: FROM SIGNALING CONTROLLING TUMOR GROWTH AND METASTASIS TO PRECISION MEDICINE. Saverio Gentile 2879-Pos Board B425 KV11.1 CHANNEL ACTIVITY CONTROL REACTIVE OXYGEN SPECIES (ROS) HOMEOSTASIS IN BREAST CANCER CELLS. Vitaly Senyuk , Alexandra Hegel, Saverio Gentile

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