Biophysical Society 2020 Annual Meeting

2880-Pos Board B426 KATP ACTIVITY IN INTESTINAL SMOOTH MUSCLE REGULATES MOTIL- ITY. Nathaniel W. York , Helen Parker, David Tyus, Zili Xie, Maham Akbar, Zihan Yan, Hongzhen Hu, Maria S. Remedi, Colin G. Nichols 2881-Pos Board B427 REPURPOSING THE KIR6.2/SUR2 CHANNEL ACTIVATOR MINOXIDIL TO TREAT GYNECOLOGICAL CANCERS. Vitaly Senyuk, Angela Russo, Margaret Liotta, Ronald Potkul, Craig Beeson, Joanna Burdette, Saverio Gentile 2882-Pos Board B428 BIOPHYSICAL AND PHARMACOLOGICAL CHARACTERIZATION OF ATP- SENSITIVE POTASSIUM CHANNELS IN MICE KIR6.1 WT/V65M MIRRORING THE HUMAN CANTU’ SYNDROME. Fatima Maqoud, Rosa Scala, Antonietta Mele, Conor McClenaghan, Maria S. Remedi, Colin C. Nichols, Domenico Tricarico 2883-Pos Board B429 PHARMACOLOGICAL APPROACHES FOR TARGETING CARDIOVASCULAR AND SKELETAL MUSCLE KATP CHANNELOPATHIES. Conor McClenaghan , Yan Huang, Zihan Yan, Jacob Roeglin, Theresa Harter, Carmen Halabi, Ma- ria S. Remedi, Colin G. Nichols 2884-Pos Board B430 DEVELOPMENT OF SMALL-MOLECULE INHIBITORS OF PROTON-ACTIVAT- ED CHLORIDE CHANNELS. Eric E. Figueroa , Jerod S. Denton 2885-Pos Board B431 INHIBITORY PROFILE OF CLOZAPINE AT CIPA CARDIAC ION CHAN- NELS. Georg Andrees Bohme 2886-Pos Board B432 OPTIMIZING FOR INFORMATION CONTENT ON IONFLUX MERCURY AUTOMATED PATCH CLAMP. Arpad Mike , Krisztina Pesti, Mátyás Csaba Földi, Zsolt Bagoly, Gábor Papp, Péter Lukács 2887-Pos Board B433 PREDICTING CLINICAL RISK OF TORSADE WITH QNET: COMBIN- ING IN SILICO COMPUTER MODELING WITH IN VITRO ION CHANNEL DATA. Leigh Korbel , Randall Rasmusson, G Bett 2888-Pos Board B434 USING NEW IN VITRO CARDIAC ION CHANNEL ASSAYS AND IN SILICO MODELS TO PREDICT PROARRHYTHMIC RISK WITH AUTOMATED PATCH CLAMP DATA. Edward S. Humphries , John Ridley, Robert W. Kirby, Marc Rogers 2889-Pos Board B435 A METHOD FOR PREPARATION OF FRESHLY-ISOLATED HUMAN URINARY BLADDER SMOOTH MUSCLE CELLS: UTILITY FOR CHARACTERIZATION OF WHOLE-CELL CATION CURRENTS. John Malysz, Eric S. Rovner, Robert Wake, Georgi V. Petkov 2890-Pos Board B436 ELECTROPHYSIOLOGICAL EXAMINATION OF THE EFFECTS OF CLASSI- CAL PHARMACOLOGICAL AGENT VERAPAMIL IN PLANT BASED MODEL SYSTEM. Vilmantas Pupkis , Indre Lapeikaite, Vilma Kisnieriene Cardiac Muscle Regulation (Boards B437 - B458) 2891-Pos Board B437 Travel Awardee SELECTIVE PHOSPHORYLATION OF CMYBP-C INCREASES CROSS-BRIDGE CYCLING RATES IN PERMEABILIZED CARDIOMYOCYTES FROM SPY-C MICE. Nathaniel C. Napierski , Kevin Granger, Samantha P. Harris

2892-Pos Board B438 A TROPOMYOSIN CABLE MODEL ON THIN-FILAMENTS DEDUCED BY PROTEIN-PROTEIN DOCKING. Elumalai Pavadai , Michael J. Rynkiewicz, William Lehman 2893-Pos Board B439 A METHOD TO STUDY CONTRACTILITY OF SKINNED FROZEN SECTIONS OF MOUSE VENTRICULAR PAPILLARY MUSCLE AND THE EFFECT OF THE RESTRICTIVE TRUNCATION OF THE N-TERMINAL EXTENSION OF CARDIAC TROPONIN I. Hanzhong Feng , J.p. Jin 2894-Pos Board B440 THE C-TERMINAL END PEPTIDE OF TROPONIN I AS A MYOFILAMENT CA 2+ DESENSITIZER. Sienna Wong, Han-Zhong Feng, J.p. Jin 2895-Pos Board B441 AN INDEPENDENT POOL OF GSK-3Β MODULATES CALCIUM SENSITIVITY AT THE CARDIAC MYOFILAMENT. Marisa J. Stachowski , Andrei Zlobin, Maria Papadaki, Edith Perez, Jody L. Martin, Nitha Aima Muntu, Christine S. Moravec, Jonathan A. Kirk 2896-Pos Board B442 A NOVEL FUNCTION OF THE POLY-GLUTAMIC ACID SEGMENT OF INSECT TROPONIN T TESTED IN MOUSE HEART FOR IMPROVING CARDIAC EF- FICIENCY. Tianxin Cao , Hanzhong Feng, J.p. Jin 2897-Pos Board B443 BIOPHYSICS OF THE SERCA2A/DWORF COMPLEX, IMPLICATIONS FOR TREATMENT OF HEART FAILURE. Ang Li , Daniel Stroik, Tory Schaaf, Sa- mantha Yuen, Evan Kleinboehl, Razvan L. Cornea, David D. Thomas 2898-Pos Board B444 DEAMIDATION OF ASPARAGINE14 PREVENTS SERINE15 PHOSPHORYLA- TION OF HUMAN CARDIAC MLC2V. Paul Goldspink, Jody L. Martin , Chad M. Warren, Walter Thompson, Elena Levi-D’Ancona, Pieter P. de Tombe 2899-Pos Board B445 MODUMODULATION BY INOTROPIC INTERVENTIONS OF THE REGULA- TORY STATE OF THE CARDIAC THICK FILAMENT IN DIASTOLE. Marco Caremani, Serena Governali, Massimo Reconditi, Francesca Pinzauti, Theyencheri Narayanan, Ger J. Stienen, Marco Linari, Vincenzo Lombardi , Gabriella Piazzesi 2900-Pos Board B446 ACTIN-BINDING COMPOUNDS, DISCOVERED FROM FRET-BASED HIGH- THROUGHPUT SCREENING, DIFFERENTIALLY AFFECT SKELETAL AND CAR- DIAC MUSCLE. Piyali Guhathakurta , Lien Phung, Sarah Lichtenberger, Ewa Prochniewicz, David D. Thomas 2901-Pos Board B447 MAVACAMTEN DECREASES MAXIMAL FORCE AND CA 2+ -SENSITIVITY OF CONTRACTION IN MYOCARDIAL STRIPS FROM A MOUSE MODEL FOR HY- PERTROPHIC CARDIOMYOPATHY. Peter O. Awinda , Marissa Watanabe, Yemeserach Bishaw, Katarzyna Kazmierczak, Danuta Szczesna-Cordary, Bertrand C. Tanner 2902-Pos Board B448 IN SILICO ENGINEERING OF CALMODULIN TO BIND THE CARDIAC RY- ANODINE RECEPTOR WITH HIGH AFFINITY. Vladimir Bogdanov , Svetlana Tikunova, Yongjun Kou, Nick Fadell, Julia Evans, Anthony Tirone, Garrett Hauck, Christopher Johnson, Steffen Lindert, Sandor Gyorke, Jonathan P. Davis 2903-Pos Board B449 TWO MYOFILAMENT-BASED APPROACHES TO PREVENT GENETIC DILAT- ED CARDIOMYOPATHY. Claire E. Branley , Farid Moussavi-Harami, Kristina B. Kooiker, Michael Regnier, Jil C. Tardiff, Joelle Tudor, Jeremy Freeman

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