Biophysical Society 2020 Annual Meeting

250-Pos Board B81 RAS SIGNALING IN THE PI3K/AKT/MTOR PATHWAY. Ruth Nussinov , Ming- zhen Zhang, Hyunbum Jang 251-Pos Board B82 INTERLEUKIN-2 DRUGGABILITY IS MODULATED BY GLOBAL CONFORMA- TIONAL TRANSITIONS THAT ARE CONTROLLED BY A HELICAL CAPPING SWITCH. Viviane De Paula , Kevin M. Jude, Santrupti Nerli, Caleb R. Glass- man, K. Christopher Garcia, Nikolaos Sgourakis 252-Pos Board B83 HYDROGEN EXCHANGE AND NMR DYNAMICS REVEAL POSITIONS STABI- LIZED BY P53 RESCUE MUTANTS N239Y AND N235K.  Jenaro Soto , Colleen L. Moody, Ali Alhoshani, Melanie J. Cocco 253-Pos Board B84 Travel Awardee CLOCK OUTPUT SERVES DUAL PURPOSE OF GENE REGULATION AND TIME KEEPING.  Joel C. Heisler , Jeffrey A. Swan, Archana G. Chavan, Carrie L. Partch, Andy LiWang 254-Pos Board B85 FROM INDUCING ALLOSTERIC SIGNALING TO EXPLORING THE ALLOSTE- RIC EFFECT OF SNPS AND ALLOSTERIC POLYMORPHISM. Wei-Ven Tee , Enrico Guarnera, Zhen Wah Tan, Igor N. Berezovsky 255-Pos Board B86 INVESTIGATING THE RESIDUE-LEVEL DYNAMICS OF THE THROMBIN- THROMBOMODULIN INTERACTION. Riley B. Peacock , Taylor McGrann, Elizabeth A. Komives 256-Pos Board B87 ASYMMETRY IN DYNAMIC ALLOSTERIC RESIDUE COUPLING (DARC) INTERACTIONS CAPTURES EVOLUTIONARY LANDSCAPE. Paul Campitelli , S. Banu Ozkan, Liskin Swint-Kruse 257-Pos Board B88 ARE CRYPTIC POCKETS IN Β-LACTAMASES FUNCTIONAL?  Catherine R. Knoverek , Shreya Raavicharla, Justin R. Porter, Upasana L. Mallimadugula, Emily Wood, Gregory R. Bowman 258-Pos Board B89 REBINDING DYNAMICS OF CO WITH CYTOGLOBIN IN AQUEOUS SOLU- TION. Joohyang Shin, Seongchul Park, Manho Lim 259-Pos Board B90 ROLE OF TRANSIENT HELICITY AND HEAT CAPACITY IN COUPLED FOLDING AND BINDING OF P53TAD TO MDM2 AND MDMX. Pirada S. Higbee , Gary W. Daughdrill, Peng Sang, Jianfeng Cai 260-Pos Board B91 Travel Awardee ELUCIDATING THE ACTIVATING MECHANISM OF GATEKEEPER MUTA- TIONS ON RECEPTOR TYROSINE KINASES. Alida Besch , WilliamMarsiglia, Moosa Mohammadi, Yingkai Zhang, Nate Traaseth 261-Pos Board B92 EFFECTS OF HUMANLIKE MUTATIONS ON YEAST ISO-1-CYTOCHROME C . Ariel Frederick 262-Pos Board B93 THE N-TERMINAL FRAGMENT (ATF) REGULATES THE DYNAMICS AND THE ACTIVITY OF THE PROTEASE DOMAIN OF THE UROKINASE-TYPE PLAS- MINOGEN ACTIVATOR (UPA). Constanza Torres-Paris , Lufan Xiao, Yueyi Chen, Francis X. Alipranti, Mahima Masih, Elizabeth A. Komives 263-Pos Board B94 REVISITING A CLASSICAL ALLOSTERIC MODEL - EXAMINATION OF AN OBLITERATED INTERFACE. Antonio Tsuneshige , Satoru Unzai

264-Pos Board B95 DYNAMIC ALLOSTERIC RESIDUE COUPLING REVEALS DISEASE MECHANISM FOR GAUCHER DISEASE AND NSNVS ACROSS THE PRO- TEOME. Nicholas Ose , Brandon M. Butler, Avishek Kumar, S. Banu Ozkan, Sudhir Kumar 265-Pos Board B96 DYNAMIC CONSEQUENCES OF INACTIVATING THE CATALYTIC SERINE 195 TO METHIONINE IN THE HUMAN UROKINASE-TYPE PLASMINOGEN ACTI- VATOR (UPA). Mahima Masih , Francis X. Alipranti, Constanza Torres-Paris, Elizabeth A. Komives Membrane Protein Dynamics I (Boards B97 - B116) 266-Pos Board B97 INVESTIGATING THE DYNAMICS IN VIBRIO CHOLERAE PATHOGENICITY BY SINGLE-MOLECULE PALM AND BAYESIAN STATISTICS. Eric D. Donarski , Josh D. Karslake, Lucas Demey, Victor J. DiRita, Julie Biteen 267-Pos Board B98 DEVELOPMENT AND IMPLEMENTATION OF A SINGLE-MOLECULE PLAT- FORM TO STUDY THE MECHANISM OF THE BETA-BARREL ASSEMBLY MACHINE COMPLEX. Megan E. Mitchell , Marcelo C. Sousa 268-Pos Board B99 INVESTIGATION OF THE SPATIO-TEMPORAL DYNAMICS OF GLUT4 IN CARDIOMYOCYTES. Anna Magdalena Koester 269-Pos Board B100 CADHERIN EXTRACELLULAR DOMAIN CLUSTERING IN THE ABSENCE OF TRANS-INTERACTIONS. Connor Thompson , Vinh H. Vu, Deborah E. Leck- band, Daniel K. Schwartz 270-Pos Board B101 DETERMINING MEMBRANE PROTEIN INTERACTION KINETICS THROUGH SINGLE-MOLECULE IMAGING AND STOCHASTIC MODELING. Luciana R. de Oliveira, Khuloud Jaqaman 271-Pos Board B102 HOW DIFFERENT ANIONIC LIPIDS SORT DYNAMICS OF KRAS4B ON MODEL MEMBRANES, POPS VERSUS PIP2 IN MILLISECOND ALL ATOM MOLECULAR DYNAMICS SIMULATIONS. Van A. Ngo , Sumantra Sarka, Chris Neale, Angel E. Garcia 272-Pos Board B103 THE INFLUENCE OF LIPIDS ON THE ASSEMBLY OF AQUAPORIN Z.  Batiste Thienpont , James N. Sturgis 273-Pos Board B104 DOMAINS OF ACTIVATED GPCRS MEDIATED BY MEMBRANE CURVA- TURE. Line Lauritsen, Christopher G. Shuttle, Eleftheria Kazepidou , Dimitrios Stamou 274-Pos Board B105 HIGH SPEED AFM IMAGING OF STRUCTURE AND DYNAMICS OF BACTE- RIAL ABC TRANSPORTER MSBA DURING LIPID TRANSPORT. XuanKien Ngo 275-Pos Board B106 EGF SIGNALING IN EPITHELIAL CARCINOMA CELLS UTILIZES HIGHER OR- DER ARCHITECTURES OF EGFR AND HER2. Adam J. Wollman , Charlotte Fournier, Isabel Llorente-Garcia, Oliver Harriman, Sviatlana Shashkova, Alex Hargreaves, Peng Zhou, Djamila Ouaret, Jenny Wilding, Akihiro Kusumi, Walter Bodmer, Mark C. Leake 276-Pos Board B107 BRIDGING BIOCHEMICAL ACTIVITIES WITH CONFORMATIONAL DYNAM- ICS OBSERVED IN ATOMIC FORCE MICROSCOPY. Kanokporn Chattrakun , David P. Hoogerheide, Chunfeng Mao, Linda L. Randall, Gavin King

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