Biophysical Society 2020 Annual Meeting

289-Pos Travel Awardee BIOPHYSICAL CHARACTERIZATION OF COVALENTLY MODIFIED PROTEIN TAU: OLIGOMERS, AGGREGATION, AND TUBULIN INTERACTIONS. Diana M. Acosta , David Eliezer 290-Pos Board B121 EXPLORING SERUM PROTEINS TO STABILIZE THE CONFORMATION OF THE PRECURSOR PROTEIN OF ANP. Yuji Hidaka , Hayato Ueda, Shigeru Shimamoto 291-Pos Board B122 UNRAVELING THE MECHANISM OF FUNCTIONAL AND PATHOLOGI- CAL AMYLOID FORMATION FROM INTRINSICALLY DISORDERED PRO- TEINS. Mily Bhattacharya , Anjali Giri, Jaspreet Kaur, Priyanka Dogra, Samrat Mukhopadhyay 292-Pos Board B123 EFFECT OF FAMILIAL ALZHEIMER’S DISEASE MUTATIONS OF THE FOLDING FREE ENERGY OF AMYLOID BETA-PEPTIDE. Darcy S. Davidson , Joshua A. Kraus, Julia M. Montgomery, Justin A. Lemkul 293-Pos Board B124 DOMAIN SWAPPING IN CRYSTALLIN PROTEINS CAN DRIVE EARLY STAGES OF CATARACT FORMATION. Govardhan Reddy Patluri , Balaka Mondal 294-Pos Board B125 HUNTINGTIN AGGREGATION AND LIPID BINDING ARE INFLUENCED BY PHYSICOCHEMICAL PROPERTIES OF MEMBRANES. Maryssa Beasley , Sharon E. Groover, Nicolas C. Frazee, Blake Mertz, Stephen J. Valentine, Justin A. Legleiter 295-Pos Board B126 THE DYNAMISM OF INTRINSICALLY DISORDERED PROTEINS IN LIQUID- LIQUID PHASE SEPARATION. Samrat Mukhopadhyay , Anupa Majumdar, Priyanka Dogra, Shiny Maity, Ashish Joshi 296-Pos Board B127 STRUCTURE AND FUNCTION IMPLICATIONS OF CONFORMATIONAL ENSEMBLES CONSISTENT WITH NMR, SAXS, AND SMFRET DATA. THE DISORDERED PROTEIN SIC1 BEFORE AND AFTER MULTISITE PHOSPHORY- LATION. Gregory W. Gomes , Mickael Krzeminski, Erik W. Martin, Tanja Mittag, Julie D. Forman-Kay, Claudiu C. Gradinaru 297-Pos Board B128 INTRINSICALLY DISORDERED HAX-1 REGULATES PHOSPHOLAMBAN IN MEMBRANES. Erik K. Larsen , Daniel Weber, Songlin Wang, Seth L. Robia, Gianluigi Veglia 298-Pos Board B129 THE EFFICACY OF DESIGNED ANTI-MEASLES VIRUS PEPTIDES DEPENDS ON THE STABILITY OF SELF-ASSEMBLED CLUSTERS. Diogo A. Mendonça 299-Pos Board B130 SOLUTION SPACE FINGERPRINTS OF INTRINSICALLY DISORDERED RE- GIONS. David Moses , Nora Shamoon, Shahar Sukenik 300-Pos Board B131 METHIONINE OXIDATION ALTERS THE MECHANISM OF AΒ INTERACTION WITH DMPC BILAYERS. Christopher Lockhart , Amy K. Smith, Dmitri K. Klimov 301-Pos Board B132 STRUCTURAL AND PHYSICAL BASIS FOR THE HIGHER AFFINITY TO ON- COPROTEIN MDM2 OF A PEPTIDE SELECTED WITH MRNA DISPLAY OVER TUMOR SUPPRESSOR P53. Takashi Nagata , Tatsuya Yamada, Tomohiko Hayashi, Simon Hikiri, Naohiro Kobayashi, Mitsunori Ikeguchi, Masato Katahira, Masahiro Kinoshita, Hiroshi Yanagawa Board B120

277-Pos Board B108 DYNAMIC INTERNAL MOTION OF GPCR ON LIVE CELLS. Masaki Ishihara , Shoko Fujimura, Kohei Ichiyanagi, Shunsuke Nozawa, Shinichi Adachi, Ryo Fukaya, Masahiro Kuramochi, Hiroshi Sekiguchi, Kazuhiro Mio, Yuji C. Sasaki 278-Pos Board B109 CORRELATION OF HIGH-SPEED AFM AND ELECTROPHYSIOLOGY MEA- SUREMENTS TO STUDY ION CHANNEL STRUCTURE-FUNCTION RELATION- SHIPS. Raghavendar Reddy Sanganna Gari , George R. Heath, Crina M. Nimigean, Simon Scheuring 279-Pos Board B110 CARDIOLIPIN’S DOUBLE LIFE AS A SUBSTRATE AND DYNAMIC REGULATOR IN PRO-APOPTOTIC LIPID PEROXIDATION. Mingyue Li, Abhishek Mandal, Vladimir A. Tyurin, Maria DeLucia, Jinwoo Ahn, Valerian Kagan, Patrick C.A. van der Wel 280-Pos Board B111 EXPLORING THE PROTEIN-MEMBRANE INTERACTIONS ON THE INTRA- CELLULAR SIDE OF PRLR. Raul Araya-Secchi , Katrine Bugge, Birthe B. Kragelund, Lise Arleth 281-Pos Board B112 RAS FAMILY MEMBER RIT1 INTERACTS WITH THE MEMBRANE VIA C TER- MINAL PEPTIDE TAIL WITHOUT LIPID ANCHOR. Amy Migliori 282-Pos Board B113 SINGLE MOLECULE IMAGING OF HIV-1 ENVELOPE DYNAMICS AND GAG LATTICE ASSOCIATION EXPOSES DETERMINANTS RESPONSIBLE FOR VIRUS INCORPORATION. Nairi Pezeshkian , Nicholas S. Groves, Schuyler B. van Engelenburg 283-Pos Board B114 AN INVESTIGATION OF THE INFLUENZA HEMAGGLUTININ MEMBRANE FUSION PROCESS USING MICROSECOND-LEVEL MD SIMULATIONS.  Vivek Govind Kumar , Dylan S. Ogden, Adithya Polasa, Mahmoud Moradi 284-Pos Board B115 PROBING THE FUNCTIONAL RELEVANCE OF THE TIP-TO-TIP ACRAB-TOLC STRUCTURAL MODEL.  Isoiza Ojo , Yinan Wei 285-Pos Board B116 STRUCTURAL DYNAMICS OF SINGLE METABOTROPIC GLUTAMATE RECEP- TOR DIMERS. Robert Quast, Anne-Marinette Cao, Fataneh Fatemi, Linnea Olofsson, Philippe Rondard, Jean Philippe Pin, Emmanuel Margeat Intrinsically Disordered Proteins (IDP) and Aggregates I (Boards B117 - B140) 286-Pos Board B117 INVESTIGATING THE CONFORMATIONAL ENSEMBLES OF INTRINSICALLY- DISORDERED PROTEINS WITH A SIMPLE PHYSICS-BASED MODEL. Yani Zhao, Robin Cortes-Huerto, Kurt Kremer, Joseph F. Rudzinski 287-Pos Board B118 COOPERATIVE INHIBITION OF SNARE-MEDIATED VESICLE FUSION BY ALPHA-SYNUCLEIN MONOMER AND OLIGOMER. Gyeongji Yoo , Yoonjung Cho, Soojin Park, Nam Ki Lee 288-Pos Board B119 Travel Awardee MULTIVALENCY OF PROTEINS AND THEIR INTERACTIONS PREDICT THEIR PHASE SEPARATION. Dan Deviri , Amy R. Strom, Gary Karpen, Samuel Safran

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