Biophysical Society 2020 Annual Meeting

302-Pos Board B133 SOLUTION NMR INVESTIGATION OF PROLINE-RICH DOMAINS REVEALS MECHANISM OF MODULATION OF SIGNAL TRANSDUCTION.  Ruben D. Elias , Bhargavi Ramaraju, Lalit Deshmukh 303-Pos Board B134 DISSECTING THE NUCLEAR PORE-LIKE PERMEABILITY BARRIER FUNCTION OF PHASE SEPARATED LIQUID FG NUCLEOPORIN CONDENSATES.  Panagiotis A. Patsis , Giorgia Celetti, Giulia Paci, Joana Caria, Miao Yu, Tom Scheidt, Virginia VanDelinder, George Bachand, Edward A. Lemke 304-Pos Board B135 STRUCTURAL BASIS OF ALPHA SYNUCLEIN ASSEMBLY TOXICITY INHIBI- TION BY HUMAN SERUM ALBUMIN. Rashik Ahmed , Jinfeng Huang, Adree Khondker, Maikel C. Rheinstadter, Madoka Akimoto, Vincent Huynh, Ryan G. Wylie, Jose C. Bozelli Jr., Richard M. Epand, Giuseppe Melacini 305-Pos Board B136 INVESTIGATING THE BINDING MECHANISMS OF INTRINSICALLY DISOR- DERED TRANSACTIVATION DOMAINS TO THE TAZ1 DOMAIN OF CBP VIA MOLECULAR DYNAMICS SIMULATION. Meng Gao, Jing Yang, Sen Liu, Zhengding Su, Yongqi Huang 306-Pos Board B137 SOLUTION STRUCTURE DETERMINATION OF ARABIDOPSIS THALIANA RALF8 ILLUSTRATES THE USE OF CUTTING-EDGE SOFTWARE DEVEL- OPED AT THE NATIONAL MAGNETIC RESONANCE FACILITY AT MADI- SON. Woonghee Lee , Marco Tonelli, Ronnie O. Frederick, Miyoshi Haruta, Gabriel Cornilescu, Claudia C. Cornilescu, Michael R. Sussman, John L. Board B138 REGULATING THE ACTIVATION OF ASH1/ASH1L HISTONE METHYLTRANS- FERASE BY INTRINSICALLY DISORDERED REGIONS.  Jing Yang , Meng Gao, Yongqi Huang 308-Pos Board B139 NEAREST NEIGHBOR EFFECTS IN HOMOPEPTIDE SEGMENTS OF SHORT PEPTIDES EXPLORED BY CIRCULAR DICHROISM AND NMR SPECTROSCO- PY. Bridget Milorey , Harald Schwalbe, Reinhard Schweitzer-Stenner 309-Pos Board B140 ENTROPIC LIMITS OF SIMULTANEOUS BINDING TO T CELL RECEPTOR DISORDERED DOMAINS. Lara Clemens , Omer Dushek, Jun F. Allard DNA Structure and Dynamics I (Boards B141 - B160) 310-Pos Board B141 HIGH-RESOLUTION SINGLE-CELL MODELS OF ENSEMBLE CHROMATIN STRUCTURES DURING DROSOPHILA EMBRYOGENESIS FROM POPULA- TION HI-C. Qiu Sun 311-Pos Board B142 RESTRICTED MOBILITY OF DNA PACKAGED IN PHAGE PHI29 VIRAL PRO- HEADS ASSESSED BY SINGLE-MOLECULE OPTICAL TWEEZERS MEASURE- MENTS OF DNA EXIT. Mounir Fizari , Douglas E. Smith 312-Pos Board B143 BACTERIAL NUCLEIC ACID QUADRUPLEX FORMATION. Lucille H. Tsao , Amelia Cecere, Hikari Murayama, Sally Shepardson-Fungairino, Megan E. Nunez 313-Pos Board B144 LOOP EXTRUSION IN CHROMATIN: A QUESTION OF TIME! Ajoy Maji , Ranjith Padinhateeri, Mithun K. Mitra Markley 307-Pos

314-Pos Board B145 INVESTIGATION OF THE SPIROIMINODIHYDANTOIN LESION’S STRUC- TURAL AND DYNAMIC EFFECTS ON AN 11-MER DEOXYRIBONUCLEOTIDE DUPLEX. Laurie C. Brutus , Elizabeth Jamieson, Cristina Suarez, Megan E. Nunez 315-Pos Board B146 NON-ERGODIC TRANSPORT AND CONFORMATIONAL DYNAMICS OF DNA IN BIOMIMETIC CYTOSKELETON NETWORKS.  Jonathan Garamella , Gina Aguirre, Ryan McGorty, Rae Anderson 316-Pos Board B147 DYNAMIC INTERCONVERSIONS BETWEEN G-QUADRUPLEX CONFIGU- RATIONS IN THE HUMAN BCL-2 PROXIMAL PROMOTER REVEALED BY SINGLE-MOLECULE SPECTROSCOPY.  I-Ren Lee , Hao-Yi Hsu, Chiao-Ying Chen 317-Pos Board B148 TBA MARKEDLY ALTERS A-TRACT OLIGOS. Earle Stellwagen 318-Pos Board B149 INTEGRATIVE MODELING OF NUCLEOSOMES AND SUPRANUCLEOSO- MAL STRUCTURES. Grigoriy Armeev , Anna Panchenko, Alexey Feofanov, Alexey K. Shaytan 319-Pos Board B150 TWO-METAL ION MECHANISM OF DNA CLEAVAGE IN CRISPR-CAS9.  Giulia Palermo , Lorenzo Casalino, Martin Jinek 320-Pos Board B151 SINGLE-MOLECULE STUDIES OF SUPRAMOLECULAR DNA STRUCTURE AT 1-NM RESOLUTION. Phil Haynes 321-Pos Board B152 MAPPING LATERAL LOOP CONFORMATIONAL SWITCHING OF THE TELOMERIC DNA G-QUADRUPLEX ON NMM PROPHYRIN BINDING USING FLUORESCENT GUANINE ANALOGS.  Jessica Desamero , Lesley Davenport 322-Pos Board B153 CONFORMATIONAL PREFERENCES OF DNA STRANDS FROM C-MYC PROMOTER REGION. Lutan Liu , Congshan Ma, James W. Wells, Tigran V. Board B154 AN IMAGE-BASED APPROACH TO THE EVALUATION OF ONCOGENE ACTIVATION EFFECTS ON CELL’S GENOMIC STABILITY. Elena Cerutti , Isotta Cainero, Gaetano Ivan Dellino, Mario Faretta, Pier Giuseppe Pelicci, Alberto Diaspro, Luca Lanzano 324-Pos Board B155 DYNAMICS OF THE 1:2:1 AND 1:6:1 C-MYC G-QUADRUPLEXES WITH THE DRUDE POLARIZABLE FORCE FIELD. Tanner Dean , Alexa M. Salsbury, Justin A. Lemkul 325-Pos Board B156 THE INCLUSION OF A GCAA TETRALOOP AFFECTS THE UNFOLDING THER- MODYNAMICS OF INTRAMOLECULAR DNA STRUCTURES. Irine Khutsish- vili, Carolyn E. Carr, Luis A. Marky 326-Pos Board B157 USE OF MICROCT SCANNER TO CHARACTERIZE THE HISTOTECHNOLOGI- CAL PROCESSING OF BONE USING DIFFERENT TISSUE FIXATIVES: RELA- TIONSHIP TO DNA PRESERVATION (IMMUNOHISTOCHEMISTRY). Francis G. DeOcampo , Claude E. Gagna, Anthony N. Yodice, Shaheryar M. Gill, Zabi Khwaja, Megha Gupta, Ilaha Jalilova, Mina Ahsan, Alisha Malhotra, Peter Lambert, Clark Lambert Chalikian 323-Pos

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