Biophysical Society 2020 Annual Meeting

461-Pos Board B292 FUNCTIONAL RELEVANCE OF ORTHOSTERIC BINDING SITE OF 5-HY- DROXYTRYPTAMINE 2A RECEPTOR AND THE MECHANISM OF RECEPTOR ACTIVATION. Yu Xu , Guoqing Xiang, Takeharu Kawano, Diomedes E. Logothetis 462-Pos Board B293 INVESTIGATING THE MECHANISM OF STRA6-MEDIATED CELLULAR RETINOL UPTAKE. Brianna K. Costabile , Yun-Ting Chen, Jonathan Kim, Youn-Kyung Kim, Oliver B. Clarke, Paul T. Wilder, David J. Weber, Loredana Quadro, Hui Sun, Filippo Mancia 463-Pos Board B294 NEUROTRANSMITTER RECEPTORS AS KEY PHYSIOLOGICAL REGULATORS OF EPITHELIAL MORPHOGENESIS. Fnu Nilay Kumar , Francisco Huizar, Maria Unger, Dharsan Soundarrajan, Vijay Velagala, John Koren, Jeremiah J. Zartman 464-Pos Board B295 SINGLE MOLECULE FORCE SPECTROSCOPY OF CHONDROCYTE Α5Β1 AND Α1Β1 INTEGRINS. Divya Kota , Ishara S. Ratnayake, Lin Kang, Phil Ahren- kiel, Congzhou Wang, Scott Wood, Steve Smith 465-Pos Board B296 SIGNALING THROUGH IONS IS ESSENTIAL FOR CHEMOTROPISM AND REPRODUCTION.  Jose A. Feijo 466-Pos Board B297 Travel Awardee TUNING OF METABOTROPIC GLUTAMATE RECEPTOR ASSEMBLY AND ACTIVATION BY INTERACTIONS BETWEEN TRANSMEMBRANE DO- MAINS.  Jordana K. Thibado , Vanessa Gutzeit, Josh T. Levitz 467-Pos Board B298 ELUCIDATING THE ADHESIVE MECHANISM OF THE ATYPICAL CADHERIN CELSR1 INVOLVED IN PLANAR CELL POLARITY. Elakkiya Tamilselvan , Marcos M. Sotomayor 468-Pos Board B299 A FLUORESCENCE-BASED BIOSENSOR FOR MONITORING CONFOR- MATIONAL DYNAMICS IN GPCRS. Anthony D. Shumate , Christopher T. Schafer, David L. Farrens 469-Pos Board B300 REVEALING THE MECHANISTIC DETAILS OF GROWTH HORMONE RECEP- TOR AND PROLACTIN RECEPTOR INTERACTIONS ON THE CELL MEM- BRANE. Chen Chen , Jing Jiang, Tejeshwar C. Rao, Stuart J. Frank, André Leier 470-Pos Board B301 EFFECTS OF LUTEINIZING HORMONE RECEPTOR EXPRESSION LEVEL ON RECEPTOR AGGREGATION AND FUNCTION. Duaa Althumairy, Deborah A. Roess, B. George Barisas 471-Pos Board B302 PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A AND DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION. Yuchen Yang , Candice N. Hatch- er-Solis, Maria P. Papakonstantinou, Albert A. Steiner, Takeharu Kawano, Leigh D. Plant, Diomedes E. Logothetis 472-Pos Board B303 GPCR STIMULATION MODULATES CAMKII TRANSLOCATION AND TARGET- ING IN CARDIOMYOCYTES. Chidera C. Alim , Maura Ferrero, Sonya Baidar, Donald M. Bers, Julie Bossuyt 473-Pos Board B304 UNNATURAL AMINO ACID RECEPTOR INCORPORATION AS A NOVEL PHO- TOAFFINITY TOOL FOR GPCR HETEROMER SIGNALING STUDIES.  Brenda T. Winn , Chungsik Kim, Meng Cui, Roman Manetsch, Diomedes E. Logothetis

474-Pos Board B305 DECIPHERING THE NATURE OF M1R TRANSIENT CURRENTS.  Verena Burtscher , Peter S. Hasenhuetl, Matej Hotka, Michael Freissmuth, Walter Sandtner 475-Pos Board B306 SEEKING THE INTERFACES OF EPH RECEPTOR INTERACTIONS.  Taylor P. Light , Kelly Karl, Jeffrey J. Gray, Kalina Hristova 476-Pos Board B307 INTEGRIN-DEPENDENT DIFFERENCE IN CELL ADHESION AND FORCE EXER- TION. Myung Hyun Jo , Jing Li, Timothy A. Springer, Taekjip Ha 477-Pos Board B308 Travel Awardee PROBING THE HOMO- AND HETERO-DIMERIZATION PROPENSITIES OF METABOTROPIC GLUTAMATE RECEPTORS.  Joon Lee , Vanessa Gutzeit, Josh T. Levitz 478-Pos Board B309 Travel Awardee BETA-ADRENERGIC SIGNALING MODULATES CANCER CELL MECHANO- TYPE THROUGH A RHOA-ROCK-MYOSIN II AXIS. Tae-Hyung Kim , Esteban Vazquez-Hidalgo, Alexander Abdou, Xing HawMarvin Tan, Alexei Christo- doulides, Carly Farris, Pei‐Yu Chiou, Erica Sloan, Parag Katira, Amy Rowat 479-Pos Board B310 DIFFERENT FGFS STIMULATE FGFR1 IN DIFFERENT WAYS. Kelly A. Karl , Kalina Hristova 480-Pos Board B311 FUNCTIONAL OLIGOMERIZATION OF THE EPHA2 RECEPTOR TYROSINE KINASE. Xiaojun Shi , Ryan Lingrak, Carmelle Cuizon, Paul Toth, Ji Zheng, Adam Smith, Bingcheng Wang 481-Pos Board B312 STUDYING THE INTERACTION OF RECEPTOR TYROSINE KINASES AND ADAPTOR PROTEINS AT THE SINGLE-MOLECULE LEVEL WITH SINGLE- PARTICLE TRACKING. Tim Niklas Baldering , Johanna Rahm, Sebastian Malkusch, Marina S. Dietz, Mike Heilemann 482-Pos Board B313 SINGLE-MOLECULE IMAGING REVEALS CHEMOKINE RECEPTOR CONTRI- BUTIONS TO THE T CELL IMMUNOLOGICAL SYNAPSE.  James H. Felce , Michael L. Dustin Excitation-Contraction Coupling I (Boards B314 - B331) 483-Pos Board B314 INVESTIGATING DUAL CA 2+ MODULATION OF THE RYANODINE RECEPTOR 1 BY MOLECULAR DYNAMICS SIMULATION. Wenjun Zheng , Han Wen 484-Pos Board B315 MOLECULAR DYNAMICS AND CA 2+ IMAGING OF MUTANT TYPE 1 RYANO- DINE RECEPTOR. Toshiko Yamazawa , Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kanemaru Kazunori, Takashi Sakurai, Masamitsu Iino 485-Pos Board B316 CHARACTERIZATION OF NOVEL RYR1-SELECTIVE INHIBITORS IDENTIFIED BY HIGH-THROUGHPUT SCREENING USING ER CA 2+ MEASUREMENT. Hi- royuki Kagechika, Takashi Sakurai 486-Pos Board B317 THERAPEUTIC EFFECTS OF A NOVEL RYR1 INHIBITOR ON MALIGNANT HYPERTHERMIA-SUSCEPTIBLE MODEL MICE. Takashi Murayama , Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Satoru Noguchi, Ich- izo Nishino, Shuichi Mori, Hiroyuki Kagechika, Jose R. Lopez, Paul D. Allen

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