Biophysical Society 2020 Annual Meeting

500-Pos Travel Awardee DIMINISHED Β-ADRENERGIC RESPONSE IN PROTEIN KINASE D KNOCK- OUT CARDIOMYOCYTES.  Juliana Mira Hernandez , Christopher Y. Ko, Bruno Jacobsen, Erin Y. Shen, Benjamin W. Van, Avery Mandel, Zhong Jian, Sabine J. van Dijk, Donald M. Bers, Ye Chen-Izu, Julie Bossuyt Cardiac, Smooth, and Skeletal Muscle Electrophysiology I (Boards B332 - B344) 501-Pos Board B332 SERCA2A IS CRITICAL FOR ARRHYTHMIC RISK IN NONISCHEMIC CARDIO- MYOPATHY. An Xie , Zhen Song, Gyeoung-Jin Kang, Feng Feng, Zhilin Qu, Samuel C. Dudley 502-Pos Board B333 MUTATIONS IN KCNE1 PROMOTE CARDIAC ALTERNANS IN LONG QT SYNDROME TYPE 5 RABBITS. Tae Yun Kim , Anatoli Kabakov, Radmila Terentyeva, Dmitry A. Terentyev, YiChun Lu, Katja E. Odening, Andras Varro, Zsuzsanna Bősze, Gideon Koren, Bum-Rak Choi 503-Pos Board B334 MOLECULAR MECHANISMS UNDERLYING CARDIAC L-TYPE CHANNEL REGULATION BY LRRC10. Pedro del Rivero Morfin , Manu B. Johny 504-Pos Board B335 IMPAIRED PARASYMPATHETIC NERVOUS SYSTEM REGULATION OF HEART RATE AND SINOATRIAL NODE FUNCTION IN TYPE 2 DIABETES MELLI- TUS. Yingjie Liu , Hailey J. Jansen, Robert A. Rose 505-Pos Board B336 INTRINSIC SINOATRIAL NODE DYSFUNCTION IMPAIRS AUTONOMIC REGULATION OF HEART RATE VARIABILITY IN HYPERTENSIVE HEART DISEASE. Tristan W. Dorey , Motahareh Moghtadaei, Adam Kirkby, Robert A. Rose 506-Pos Board B337 HYPOKALEMIA PROMOTES ARRHYTHMIA BY DISTINCT MECHANISMS IN ATRIAL AND VENTRICULAR MYOCYTES. Kiarash Tazmini, Michael Frisk, Martin Laasmaa , Alexandre Lewalle, Stefano Morotti, David B. Lipsett, Ornella Manfra, Jonas Skogested, Jan Magnus Aronsen, Ivar Sjaastad, Andrew G. Edwards, Eleonora Grandi, Steven A. Niederer, Erik Øie, Wil- liam E. Louch 507-Pos Board B338 DISRUPTING THE CIRCADIAN CLOCK MECHANISM IN CARDIOMYOCYTES EXACERBATES THE LQT3-RELATED PHENOTYPE IN SCN5A ΔKPQ/+ MICE.  Jennifer Wayland , Fiaz Shah, Kaitlyn Samuels, Tanya Seward, Elizabeth Schroder, Brian P. Delisle 508-Pos Board B339 CARDIAC OVEREXPRESSION OF ADENYLYL CYCLASE TYPE VIII AUGMENTS FUNCTION OF THE COUPLED OSCILLATORY SYSTEM AND ACTION POTEN- TIAL FIRING RATE OF SINOATRIAL NODAL CELLS. Syevda Tagirova , Khalid Chakir, Dongmei Yang, Bruce D. Ziman, Yelena Tarasova, Kirill Tarasov, Edward G. Lakatta 509-Pos Board B340 O -GLYCOSYLATION OF CAMKII AT SERINE 280 PROMOTES CARDIAC AR- RHYTHMIAS IN DIABETIC HYPERGLYCEMIA. Bence Hegyi , Anna Fasoli, Christopher Y. Ko, Marisa M. Ciccozzi, Srinivas Tapa, Benjamin W. Van, Erin Y. Shen, Sonya Baidar, Julie Bossuyt, Crystal M. Ripplinger, Donald M. Bers 510-Pos Board B341 IMAGING AND ELECTROPHYSIOLOGICAL BIOMARKERS IN A NOVEL PRECLINICAL PIG MODEL OF ANTHRACYCLINE-INDUCED CARDIOTOXIC- ITY. Peter Lin, Terenz Escartin, Melissa Larsen, Jennifer Barry, Xiuling Qi, Matthew Ng, Susan Camilleri, Idan Roifman, Mihaela Pop Board B331

487-Pos Board B318 DIRECT VISUALIZATION OF TYPE 2 RYANODINE RECEPTORS USING DSTORM. David R. Scriven , Anne Berit Johnsen, Parisa Asghari, Keng Chang Chou, Edwin D. Moore 488-Pos Board B319 TOTAL CALCIUM CONTENT OF SARCOPLASMIC RETICULUM AND MI- TOCHONDRIA IN RYANODINE RECEPTOR VARIANT MUSCLE. Cedric R. Lamboley, Luke Pearce, Bradley S. Launikonis 489-Pos Board B320 STIM1 AFFECTS INTRACELLULAR CA 2+ MOVEMENT AS WELL AS EXTRA- CELLULAR CA 2+ ENTRY IN SKELETAL MUSCLE.  Jun Hee Choi , Mei Huang, Changdo Hyun, Mi Ri Oh, Keon Jin Lee, Chung-Hyun Cho, Eun Hui Lee 490-Pos Board B321 MULTIPLE SEQUENCE VARIANTS IN STAC3 AFFECT INTERACTIONS WITH CAV1.1 AND EXCITATION-CONTRACTION COUPLING. Britany Rufenach 491-Pos Board B322 TOPOLOGICAL ALLOSTERIC REGULATION OF THE SARCOPLASMIC RE- TICULUM CALCIUM PUMP PHOSPHOLAMBAN. Daniel K. Weber , Maximo Sanz-Hernandez, Venkateswara Reddy Uddigiri, Erik K. Larsen, Songlin Wang, Tata Gopinath, Alfonso De Simone, Gianluigi Veglia 492-Pos Board B323 NEURONAL JUNCTOPHILIN 3 CAN REPLACE MUSCLE JUNCTOPHILIN 2 IN VOLTAGE-INDUCED CALCIUM RELEASE. Stefano Perni , Kurt G. Beam 493-Pos Board B324 WITHDRAWN 494-Pos Board B325 DIFFERENTIAL IMPACT OF SELECTIVE DE-ADHESION WITHIN NAV1.5- RICH INTERCALATED DISK NANODOMAINS ON ATRIAL ARRHYTHMIA RISK. Heather L. Struckman , Louisa Mezache, Anna Phillips, Celine Dagher, Amara Greer-Short, Przemyslaw Radwanski, Thomas J. Hund, Rengasayee Veeraraghavan 495-Pos Board B326 CARDIOPROTECTION CONFERRED BY A CRISPR/CAS9 SINGLE AMINO ACID SUBSTITUTION OF NCX1 (H165A): THE PH INSENSITIVE NCX MOUSE.  Rui Zhang , Sabine Lotteau, Adina T. Hazan, Stephan Aynaszyan, Devina Gonzalez, Liang Li, Kenneth D. Philipson, Michela Ottolia, Joshua I. Goldhaber 496-Pos Board B327 GENETIC ABLATION OF NCX1.1 NA + -DEPENDENT INACTIVATION IMPACTS CARDIAC ACTION POTENTIAL AND CA 2+ TRANSIENT. Federica Steccanella , Kyle Scranton, Namuna Panday, Marina Angelini, Rui Zhang, Sabine Lot- teau, Scott A. John, Riccardo Olcese, Joshua I. Goldhaber, Michela Ottolia 497-Pos Board B328 THE NA + -DEPENDENT INACTIVATION OF NCX1.1 IS PHYSIOLOGICALLY RELEVANT TO CARDIAC FUNCTION. Kyle Scranton , Soban Umar, Guil- laume Calmettes, Mansoureh Eghbali, Joshua I. Goldhaber, Scott A. John, Riccardo Olcese, Ariel L. Escobar, Michela Ottolia 498-Pos Board B329 SHAPING ACTION POTENTIAL REPOLARIZATION PHASE I BY STOICHIO- METRIC EXPRESSION OF KV4.3/KCHIP2.1. Nan Wang , Eef Dries, Ewan D. Fowler, Jules C. Hancox, Mark B. Cannell 499-Pos Board B330 AUTOSOMAL-DOMINANT CASQ2-K180R CAUSES CPVT BY A DIFFERENT MECHANISM THAN AUTOSOMAL-RECESSIVE CASQ2 MUTATIONS.  MatthewWleklinski , Shan Parikh, Bjorn C. Knollmann

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