Biophysical Society 2020 Annual Meeting

511-Pos Board B342 UBIQUITIN LIGASE RIFIFYLIN (RFFL) HAS YIN-YANG EFFECTS ON RABBIT CARDIAC TRANSIENT OUTWARD (I TO ) POTASSIUM CHANNELS. Anatoli Y. Kabakov , Karim Roder, Karni S. Moshal, YiChun Lu, Mingwang Zhong, Saroj Dhakal, Alain Karma, Gideon Koren 512-Pos Board B343 POTENT SUPPRESSION OF VENTRICULAR ARRHYTHMIAS BY SELECTIVELY TARGETING LATE L-TYPE CALCIUM CURRENT. Marina Angelini , Arash Pe- zhouman, Nicoletta Savalli, Marvin Chang, Guillaume Calmettes, Federica Steccanella, Antonios Pantazis, Hrayr S. Karagueuzian, James N. Weiss, Riccardo Olcese 513-Pos Board B344 ELECLAZINE INHIBITION OF VOLTAGE-GATED SODIUM CURRENTS IN RAT ATRIAL AND VENTRICULAR MYOCYTES. Rachel E. Caves, Ben Clennell, Alexander Carpenter, Stephanie C. Choisy, Hongwei Cheng, Cameron Mc- Niff, Brendan Mann, James T. Milnes, Jules C. Hancox, Andrew F. James Voltage-gated Ca Channels (Boards B345 - B356) 514-Pos Board B345 PROBING THE EFFECTS OF CALMODULINOPATHY MUTATIONS ON CA V 2.1 CHANNELS.  John W. Hussey , Helene H. Jensen, Mette Nyegaard, Michael T. Overgaard, Ivy E. Dick 515-Pos Board B346 MYOCARDIAL RAD DELETION INCREASES EARLY L-TYPE CALCIUM CURRENT WITHOUT AFFECTING LATE CALCIUM CURRENT THROUGH MULTIPLE MECHANISMS. Brooke Ahern , Andrea Sebastian, Douglas A. Andres, Jonathan Satin 516-Pos Board B347 NON-CANONICAL ROLE OF CA V A2D1 IN CARDIAC HYPERTROPHY. Aya Al Katat , Angelino Calderone, Lucie Parent 517-Pos Board B348 THE CONTRIBUTION OF THE INDIVIDUAL VOLTAGE SENSORS TO THE ACTIVATION OF SKELETAL CA V 1.1 CHANNELS. Nicoletta Savalli , Marina Angelini, Federica Steccanella, Fenfen Wu, Marbella Quinonez, Alan Neely, Steve C. Cannon, Riccardo Olcese 518-Pos Board B349 NEURONAL NITRIC OXIDE SYNTHASE REGULATION OF CALCIUM CYCLING IN VENTRICULAR CARDIOMYOCYTES IS INDEPENDENT OF CA V 1.2 CHAN- NEL MODULATION.  Janine Michaela Ebner , Michal Cagalinec, Helmut Kubista, Hannes Todt, Petra L. Szabo, Attila Kiss, Bruno K. Podesser, Henri- etta Cserne Szappano, Livia C. Hool, Karlheinz Hilber, Xaver Koenig 519-Pos Board B350 A POTENT VOLTAGE-GATED CALCIUM CHANNEL INHIBITOR ENGINEERED FROM A NANOBODY TARGETED TO AUXILIARY CAVΒ SUBUNITS. Travis J. Morgenstern 520-Pos Board B351 PHENYLAKYLAMINES IN CALCIUM CHANNELS. EXPERIMENTAL STRUC- TURES AND COMPUTATIONAL MODELS. Denis B. Tikhonov, Lianyun Lin, Daniel S. Yang, Zhiguang Yuchi, Boris S. Zhorov 521-Pos Board B352 TWO CAV3.3 (CACNA1I) GAIN-OF-FUNCTION MUTATIONS LINKED TO EPILEPSY AND INTELLECTUAL DISABILITY AFFECT GATING PROPERTIES AND THE WINDOW CURRENT. Yousra El Ghaleb , Pauline E. Schneeberger, Abeltje M. Polstra, Johanna M. van Hagen, Marta Campiglio, Jonas Denecke, Monica Fernandez-Quintero, Klaus R. Liedl, Kerstin Kutsche, Bernhard E. Flucher

522-Pos Board B353 ARRHYTHMOGENIC CALMODULIN MUTATIONS CAN DISRUPT THE GLOBULAR STRUCTURE AND UNCOUPLE CA 2+ BINDING COOPERATIV- ITY. Kaiqian Wang , Malene Brohus, Christian Holt, Michael T. Overgaard, Reinhard Wimmer, Filip Van Petegem 523-Pos Board B354 STRUCTURAL DETERMINANTS OF VOLTAGE-GATED CALCIUM CHANNEL GATING PROPERTIES. Monica L. Fernández-Quintero 524-Pos Board B355 UNICELLULAR CAVB SUBUNIT MODULATES CALCIUM CHANNELS.  Emilie Segura , Amrit Mehta, Mireille Marsolais, Xuan R. Quan, Juan Zhao, Rémy Sauvé, John D. Spafford, Lucie Parent 525-Pos Board B356 EXPLORING THE ROLE OF THE FIRST EXTRACELLULAR LOOP OF CA V 2.3 IN MEDIATING THE INTERACTION WITH AUXILIARY SUBUNITS. Juan Zhao, Mireille Marsolais, Emilie Segura, Lucie Parent Voltage-gated K Channels I (Boards B357 - B385) 526-Pos Board B357 IDENTIFICATION OF RESIDUES CONTRIBUTING TO THE VSD-PD COUPLING IN IKS CHANNELS. Xiaoan Wu , Marta E. Perez, Peter H. Larsson 527-Pos Board B358 TEMPERATURE SENSITIVITY IN A POTASSIUM CHANNEL FROM LAND PLANTS. Bernardo I. Pinto , Francisco Bezanilla 528-Pos Board B359 A KINETIC MAP OF THE HOMOMERIC VOLTAGE-GATED POTASSIUM CHANNEL (KV) FAMILY. Rajnish Ranjan , Emmanuelle Logette, Michela Marani, Mirjia Herzog, Valerie Tache, Enrico Scantamburlo, Valérie Bu- chillier, Henry Markram 529-Pos Board B360 STABILIZATION OF THE KCNQ1 POTASSIUM CHANNEL CAUSES DIS- EASE. Hui Huang , Laura Chamness, Jonathan Schlebach, Arina Hadziseli- movic, Georg Kuenze, Jens Meiler, Alfred L. George, Charles R. Sanders 530-Pos Board B361 CONDUCTION AND SELECTIVITY IN KIR3.2 CHANNELS - A MOLECULAR DYNAMICS STUDY. Anna Stary-Weinzinger , Harald Bernsteiner 531-Pos Board B362 A CALCULATED PROTON PATH IN K V 1.2 FROM THE VOLTAGE SENSING DOMAIN S4 SEGMENT TOWARD THE GATE, WITH A HYPOTHESIS AS TO THE REMAINDER OF THE PATH. Alisher M. Kariev , Michael E. Green 532-Pos Board B363 MOLECULAR MECHANISM OF BK CHANNEL ACTIVATION BY THE SMOOTH MUSCLE RELAXANT NS11021. Michael E. Rockman , Alexandre G. Vouga, Brad S. Rothberg 533-Pos Board B364 INHIBITION OF HERG POTASSIUM CHANNELS BY THE POLYCYLIC ARO- MATIC HYDROCARBON PHENANTHRENE. Ehab Al-Moubarak , Holly Shiels, Yihong Zhang, Chunyun Du, Christopher Dempsey, Jules Hancox 534-Pos Board B365 Travel Awardee MEFENAMIC ACID BINDING AND EFFECT ON I KS CHANNEL GATING. Yundi Wang , Jodene R. Eldstrom, David Fedida

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