Biophysical Society 2020 Annual Meeting

535-Pos Board B366 HYPOXIA INHIBITS KV1.5 CURRENTS THROUGH REACTIVE OXYGEN SPECIES-MEDIATED DISULFIDE BOND FORMATION. Nancy You , Wentao Li, Jun Guo, Tonghua Yang, Shetuan Zhang 536-Pos Board B367 PROBING THE MOLECULAR BASIS OF OPPOSING PUFA EFFECTS ON KV7 CHANNELS. Damon J.A. Frampton , Louise C. Abrahamsson, Johan E. Larsson, Sara I. Liin 537-Pos Board B368 CHOLESTEROL-INDUCED TRAFFICKING OF BETA1 SUBUNITS SWITCHES MODULATION OF BK FUNCTION BY THIS STEROID FROM INHIBITION TO ACTIVATION. Anna N. Bukiya , M. Dennis Leo, Jonathan H. Jaggar, Alex M. Dopico 538-Pos Board B369 FUNCTIONAL CONSEQUENCES OF INCIDENTALLY DISCOVERED KCNQ1 VARIANTS DETERMINED BY AUTOMATED ELECTROPHYSIOLOGY.  Carlos G. Vanoye , Reshma R. Desai, Sneha Adusumilli, Jens Meiler, Charles R. Sanders, Tooraj Mirshahi, Megan J. Puckelwartz, Elizabeth M. McNally, Alfred L. George 539-Pos Board B370 Travel Awardee A FOCUSED ELECTRIC FIELD IN THE BK CHANNEL VOLTAGE SENSOR.  Ignacio A. Segura , Willy R. Carrasquel-Ursulaez, Ramon Latorre 540-Pos Board B371 CORRECTION OF HERG FUNCTIONAL EXPRESSION AND DEFECTIVE PERIPHERAL PROCESSING IN INHERITED AND ACQUIRED LQT2 SYN- DROMES. Brian Foo, William C. Valinsky, Josua Solomon, Jeeventh Kaur, Elya Quesnel, Camille Barbier, Gergely L. Lukacs, Alvin Shrier 541-Pos Board B372 TETHERED PEPTIDE NEUROTOXINS FACILITATE BIOPHYSICAL STUDY AND REVEAL TWO VOLTAGE-DEPENDENT BLOCKING MECHANISMS FOR SAK1 TOXINS IN THE K + CHANNEL PORE. Ruiming Zhao , Hui Dai, Netanel Men- delman, Jordan H. Chill, Steve A. Goldstein 542-Pos Board B373 EXTRACELLULAR HEME MODULATES VOLTAGE-GATING IN CNBD SU- PERFAMILY CATION CHANNELS. Timothy J. Jegla , Yunqing Zhou, Aditya Pisupati, Benjamin T. Simonson, Kathryn King, Damian B. van Rossum, Andriy Anishkin 543-Pos Board B374 RATIONALLY DESIGNED PROTON CHANNEL INHIBITORS REVEAL A DRUG- GABLE POCKET IN A VOLTAGE-SENSING DOMAIN. Chang Zhao , Liang Hong, Saleh Riahi, Jason D. Galpin, Christopher A. Ahern, Douglas J. Tobias, Francesco Tombola 544-Pos Board B375 MOLECULAR DETERMINANTS OF C-TYPE INACTIVATION FOR THE HERG CHANNEL AND ITS DISEASE-ASSOCIATED MUTANTS.  Jing Li , Rong Shen, Young Hoon Koh, Eduardo Perozo, Benoit Roux 545-Pos Board B376 CADMIUM AND PROTONS ACTIVATE THE PLANT HYPERPOLARIZATION- GATED K + CHANNEL KAT1 THROUGH A CONSERVED BINDING SITE IN THE VOLTAGE SENSOR DOMAIN. Yunqing Zhou , Sarah M. Assmann, Timothy J. Jegla 546-Pos Board B377 PROBING ION CHANNEL THERMODYNAMICS WITH TEMPERATURE JUMPS IN OOCYTES. Bernardo Pinto , Carlos Alberto Z. Bassetto Jr, Fran- cisco Bezanilla, Ramon Latorre 547-Pos Board B378 Travel Awardee RAPID CHARACTERISATION OF R56Q MUTANT HERG CHANNEL KINETICS USING SINUSOIDAL VOLTAGE PROTOCOLS. Dominic G. Whittaker , Jake M. Kemp, Gary R. Mirams, TomW. Claydon

548-Pos Board B379 ELECTROSTATIC INTERACTIONS OF NEGATIVELY CHARGED DHAA DERIVA- TIVES WITH THE VOLTAGE-GATED POTASSIUM CHANNEL K V 7.2/7.3.  Argel Estrada-Mondragon , Nina E. Ottosson, Xiongyu Wu, Peter Konrads- son, Fredrik Elinder 549-Pos Board B380 MOVING GATING CHARGE WITH TEMPERATURE JUMPS.  Carlos Alberto Z. Bassetto Jr , Bernardo Pinto, Ramon Latorre, Francisco Board B381 DOES PHYSICS EXPLAIN THE ACTIVATION OF VOLTAGE-GATED ION CHAN- NELS? H. Richard Leuchtag 551-Pos Board B382 VOLTAGE SENSOR MOVEMENT OF NEURONAL K V 7 CHANNELS.  Michaela Edmond , Rene Barro-Soria 552-Pos Board B383 A NEW APPROACH TO STUDY NON-CONDUCTING KV2 CHANNELS.  Emily E. Maverick , Michael M. Tamkun 553-Pos Board B384 TWO-STAGE “HAND-AND-ELBOW” GATING MECHANISM OF A K V CHAN- NEL. Panpan Hou , Po wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui 554-Pos Board B385 INHIBITION OF THE ONCOGENIC K V 10.1 POTASSIUM CHANNEL BY AMIO- DARONE AND DRONEDARONE. EFFECTS ON THE COLE-MOORE SHIFT OF THE CHANNELS. Froylan Gomez-Lagunas, Teresa Meléndez , Carolina Barriga-Montoya Ion Channels, Pharmacology, and Disease I (Boards B386 - B410) 555-Pos Board B386 Travel Awardee PREGNENOLONE CONSTRICTS CEREBRAL ARTERIES BY TARGETING THE CHANNEL-FORMING SUBUNIT OF THE SMOOTH MUSCLE BK COM- PLEX. Kelsey C. North , Luiz Moreira, Man Zhang, Alexandria Slayden, Anna Bukiya, Alejandro M. Dopico 556-Pos Board B387 CHARACTERIZATION OF NEW HUMAN KCNMA1 LOSS-OF-FUNCTION MUTATIONS. Hans J. Moldenhauer, Su Mi Park, Andrea L. Meredith 557-Pos Board B388 FUNCTIONAL AND PHARMACOLOGICAL CHARACTERIZATION OF C. EL- EGANS DEG/ENAC/ASIC CHANNELS. Sylvia Fechner , Isabel D’Alessandro, Lingxin Wang, Calvin Tower, Li Tao, Miriam B. Goodman 558-Pos Board B389 ZEBRAFISH HEART AS A MODEL FOR EARLY-SCREENING OF HUMAN ANTI- ARRHYTHMIC DRUGS. Alicia de la Cruz , Marta E Perez-Rodriguez, Quinn C. Rainer, Sara I. Liin, Peter H. Larsson 559-Pos Board B390 ALTERED CYTOSOLIC CA 2+ SIGNALING AND MITOCHONDRIAL POTENTIAL IN LYMPHOCYTES FROMMICE CARRYING THE GAIN-OF-FUNCTION MU- TATION IN RYANODINE RECEPTOR TYPE 1. Lukun Yang, Elena N. Dedkova, Paul D. Allen, Alla F. Fomina 560-Pos Board B391 RELATIVE AFFINITIES OF GENERAL ANESTHETICS FOR EXPERIMENTALLY- IDENTIFIED BINDING SITES IN RYANODINE RECEPTORS (RYR1).  Sruthi Murlidaran , Weiming Bu, Roderic G. Eckenhoff, Grace H. Branni- gan, Thomas T. Joseph Bezanilla 550-Pos

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