Biophysical Society 2020 Annual Meeting

561-Pos Board B392 MODULATION OF NATIVE AND RECOMBINANT GIRK1/2 CHANNELS BY ANALGESIC Α-CONOTOXINS. Anuja R. Bony, Jeffrey R. McArthur, Rocio K. Finol-Urdaneta, David J. Adams 562-Pos Board B393 CYSTEINE-MODIFICATION OF K V 7 CHANNELS AS ANALGESIC MECHANISM OF ACTION OF ACETAMINOPHEN.  Isabella Salzer , Sutirtha Ray, Stefan Boehm 563-Pos Board B394 ELUCIDATING THE MOLECULAR DETERMINANTS OF PRO-ARRHYTHMIC PROCLIVITIES OF BETA-BLOCKING DRUGS.  John R. Dawson , Kevin DeMarco, Pei-Chi Yang, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Igor V. Vorobyov 564-Pos Board B395 EARLY AFTERDEPOLARIZATION IN DRUG-INDUCED ARRHYTHMISAS CAN BE PREDICTED BY VOLTAGE-DEPENDENCE IN I CAL BLOCK. Akira Kimura , Shingo Murakami 565-Pos Board B396 DISCRIMINATING MECHANISMS OF DRUG ACTION FROM OPTICAL RE- CORDINGS OF VOLTAGE AND CALCIUM IN HIPSC CARDIOMYOCYTES.  Andrew G. Edwards , Stefano Morotti, Eleonora Grandi 566-Pos Board B397 DIASTOLIC SODIUM CURRENT IN CARDIOMYOCYTES ASSESSED WITH LITHIUM. Kenneth S. Ginsburg , Yanyan Jiang, Daniel C. Bartos, Sanda I. Despa, Donald M. Bers 567-Pos Board B398 RELIABLE IDENTIFICATION OF HERG LIABILITY IN DRUG DISCOVERY BY AUTOMATED PATCH CLAMP. Michael George, Rodolfo Haedo , Nina Brinkwirth, Nadine Becker, Claudia S. Haarmann, Alison Obergrussberger, Ronald Knox, Martin Hampl, Niels Fertig 568-Pos Board B399 PREDICTING ARRHYTHMOGENICITY: STRUCTURAL MODELING OF SAFE AND UNSAFE HERG BLOCKERS. Aiyana M. Emigh , Kevin DeMarco, Kazu- haru Furutani, Colleen E. Clancy, Igor V. Vorobyov, Vladimir Yarov-Yarovoy 569-Pos Board B400 CELLULAR AND FUNCTIONAL DEFECTS IN ALDOSTERONISM-LINKED CY- TOSOLIC DOMAIN MUTATIONS IN GIRK4 (KCNJ5). Reem Handklo Jamal , Boris Shalomov, Haritha P. Reddy, Neta Theodor, Mariam Ashkar, Amal K. Bera, Nathan Dascal 570-Pos Board B401 INHIBITORY MECHANISMS OF G-PROTEIN-GATED INWARDLY RECTIFY- ING K + CHANNEL BY ANTIHISTAMINES.  I-Shan Chen , Chang Liu, Michihiro Tateyama, Izhar Karbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo 571-Pos Board B402 PIEZO MECHANOSENSORY CHANNELS CONTROL CENTRIOLE ENGAGE- MENT VIA CALCIUM SIGNALING AT THE CENTROSOME. Liron David 572-Pos Board B403 PROTON DEPENDENT INHIBITION AND THE SLOW GATING MECHANISM OF CLC-0 CHLORIDE CHANNEL. Hwoi Chan Kwon 573-Pos Board B404 IMPAIRMENT OF HUMAN K V 4.3 PROTEIN BIOSYNTHESIS AND CHANNEL GATING BY NOVEL SCA19/22-ASSOCIATED MUTATIONS. Ssu-Ju Fu, Cheng- Tsung Hsiao, Bing-Wen Soong, Chih-Yung Tang , Chung-Jiuan Jeng

574-Pos Board B405 THE KCA 3.1 POTASSIUM CHANNEL MEDIATES THE TAMOXIFEN-DEPEN- DENT ANTICANCER EFFECTS IN BREAST CANCER. Vitaly Senyuk, Rudy Calderon, Daniel R. Sauter, Saverio Gentile 575-Pos Board B406 DIFFERENTIAL ROLES OF SK CHANNEL SUBTYPES IN VASCULAR ENDOTHE- LIAL CELLS. Young-Woo Nam, Taibah Aldakhil, Dong Wang, Adam Viegas, Miao Zhang 576-Pos Board B407 KINETIC AND PHARMACOLOGICAL PROPERTIES OF P2X 3 AND P2X 2/3 RECEPTORS. James L. Costantin, Timothy Strassmaier , Giustina M. Rotordam, Tom Goetze, Nadine Becker, Alison Obergrussberger, Andrea Bruggemann, Michael George, Niels Fertig 577-Pos Board B408 VOLTAGE DEPENDENT ANION CHANNELS REGULATE PROLIFERATION OF CANCER STEM CELLS. Amandine M. Rovini , Elizabeth Hunt, Kareem A. Heslop, Shenghui Qin, Monika Gooz, Gavin Wang, Eduardo N. Maldonado 578-Pos Board B409 HUMAN Α4Β2 AND Α7 NICOTINIC ACETYLCHOLINE RECEPTOR PROFILES OF NS3861 REVEAL ITS BROAD ACTIVITY IN FUNCTIONAL ELECTROPHYSI- OLOGY ASSAYS. Damian Mc Hugh , Omar Alijevic, Julia Hoeng 579-Pos Board B410 PHARMACOLOGICAL CHARACTERIZATION OF NATURAL TOBACCO ALKALOIDS IN THE PRESENCE OF POSITIVE ALLOSTERIC MODULATORS AGAINST HUMAN Α4Β2 AND Α7 NICOTINIC ACETYLCHOLINE RECEP- TORS. Omar Alijevic , Damian Mc Hugh, Anatoly Mazurov, Julia Hoeng, Manuel Peitsch Skeletal and Smooth Muscle Mechanics, Structure, and Regulation (Boards B411 - B426) 580-Pos Board B411 A CATCH BOND SUPPRESSES FLUCTUATIONS IN THE COORDINATED AC- TIONS OF MYOSIN II MOTORS.  Jason A. Wagoner 581-Pos Board B412 CHARACTERIZATION OF THE FUNCTIONAL DIVERSITY OF THE SYNTHETIC NANOMACHINE POWERED BY DIFFERENT MUSCLE MYOSIN ISO- FORMS. Irene Pertici, Giulio Bianchi, Lorenzo Bongini, Vincenzo Lombardi, Pasquale Bianco 582-Pos Board B413 RECONSTRUCTION OF REAL-SPACE 3-D STRUCTURE FROM X-RAY FIBER DIFFRACTION PATTERN: APPLICATION TO MUSCLE PROTEIN FILA- MENTS. Hiroyuki Iwamoto 583-Pos Board B414 A NOVEL MECHANISM TO REDUCE FORCE LOSS DURING PROLONGED USE OF SLOW-TWITCH MUSCLE FIBERS. Chad R. Straight, Kaylyn M. Bell, Jared N. Slosberg, Mark S. Miller, Douglas M. Swank 584-Pos Board B415 FACTORS THAT MODULATE THE STABILITY OF THE SUPER RELAXED STATE OF MYOSIN IN SKELETAL MUSCLE FIBERS. Nariman Naber, Clyde F. Wilson, Roger Cooke 585-Pos Board B416 IN SITU CHARACTERIZATION OF THE WORKING STROKE OF THE SLOW AND FAST ISOFORMS OF MUSCLE MYOSIN. Marco Caremani, Irene Per- tici, Valentina Percario, Vincenzo Lombardi, Marco Linari 586-Pos Board B417 SUB-MAXIMALLY ACTIVATED RAT SOLEUS FIBERS EXHIBIT STRETCH ACTI- VATION. Faruk H. Moonschi, Kenneth S. Campbell

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