Biophysical Society 2020 Annual Meeting

Symposium Future of Biophysics 10:45 am - 12:45 pm, Ballroom 20BC Support contributed by the Burroughs Wellcome Fund. Co-Chairs Patricia Clark, University of Notre Dame William Kobertz, University of Massachusetts Medical School No Abstract 10:45 am X-RAY SCATTERING FROM CORRELATED MOTIONS IN PROTEINS.  Nozomi Ando No Abstract 11:15 am EXPLOITING 3D TO 2D LOCALIZATION TO CONTROL PROTEIN SELF-ASSEM- BLY. Margaret Johnson No Abstract 11:45 am CONFORMATIONAL DYNAMICS OF SINGLE VIRAL MEMBRANE FUSION MACHINES.  James B. Munro No Abstract 12:15 pm SIGNALING WITH UBIQUITIN - COMMUNICATION BETWEEN METABO- LISM AND IMMUNE RESPONSES.  Elton Zeqiraj Platform Intracellular Calcium Channels and Calcium Sparks and Waves 10:45 am - 12:45 pm, Room 23ABC Co-Chairs Raul Benitez, Polytechnic University of Catalonia, Spain Maura Greiser, University of Maryland 837-plat 10:45 am OPTICAL SUPERRESOLUTION ANALYSIS OF INTRACELLULAR CALCIUM HANDLING PROTEINS AND CORRELATING CALCIUM SIGNAL MORPHOL- OGY. Miriam E. Hurley , Thomas M. Sheard, Ruth Norman, Hannah M. Kirton, Shihab S. Shah, Eleftheria Pervolaraki, Zhaokang Yang, Derek S. Steele, Nikita Gamper, Ed White, Izzy Jayasinghe 838-plat 11:00 am Travel Awardee SUB-CELLULAR HETEROGENEITY IN SERCA DETERMINES SPATIAL CAL- CIUM DYNAMICS IN CARDIOMYOCYTES. Maxx Holmes , Miriam E. Hurley, TomM.D. Sheard, Harley J. Stevenson-Cocks, Al Benson, Izzy Jayasinghe, Michael A. Colman 839-plat 11:15 am ‘CALCIUM CLOCK’ AT THE NANOSCALE IN THE RAT SA NODE: 3D RYANO- DINE RECEPTOR CLUSTER ORGANIZATION AND INTRACELLULAR CA 2+ SIGNALING.  Saif Yasin , Aaron D. Kaplan, Humberto C. Joca, W. Jonathan Lederer, Maura Greiser 840-plat 11:30 am COMPARISON BETWEEN HIPS-CM FROM RYR2-R420Q CPVT PATIENTS AND KI MICE BEARING THE SAME MUTATION.  Li Heng Yin, Alexandra Zah- radnikova jr., Riccardo Rizzetto, Pascale Gerbaud, Valerie Nicolas, Esther Zorio, Jean-Pierre Benitah, Ana M. Gomez 841-plat 11:45 am DETECTION OF CALCIUM RELEASE FROM INDIVIDUAL RYR2 CLUSTERS IN CARDIOMYOCITES.  Carme Nolla Colomer , Alexander Vallmitjana, Adela Herraiz Martínez, Hildegard Colino Lage, S.R. Wayne Chen, Leif Hove- Madsen, Raul Benitez

Another growing area is the use of 19F in bio-molecular NMR. Both the introduction of new accessories and method permit more widespread use of this nucleus in NMR studies. EPR detects unpaired electrons in free radicals and transition metal ions. One electron transfer reactions result in unpaired electrons. Examples of paramagnetic species encountered in biology are; ROS (Reactive Oxygen Species), RNS (Reactive Nitrogen Species), amino acid radicals such as tyrosine and tryptophan radicals, paramagnetic intermediates in photo- synthesis, and metalloenzymes. In addition to these naturally occurring paramagnetic species, spin labels can be incorporated into a number of biomolecules via SDSL (Site Direct- ed Spin Labeling). Applications and techniques are; motional dynamics of proteins, peptides, and nucleotides via linsehape analysis, accessibility studies in membrane proteins or peptides via saturation measurements, and distance measurements (2-8 nm) via DEER (Double Electron-Electron Resonance) to complement other structural methods such as X ‑ ray, NMR, CryoEM and FRET. Speakers Clemens Anklin, Vice President, NMR Applications & Training, Bruker Corporation Ralph Weber, EPR Applications Manager, Bruker Corporation Symposium Sensational Membrane Proteins 10:45 am - 12:45 pm, Ballroom 20A Chair Emily Liman, University of Southern California 830-symp 10:45 am FROM STRETCH TO DEFLECTION: FINE TUNING MECHANICAL ACTIVATION OF ION CHANNELS.  Jessica Richardson, Setareh Sianati, Navid Bavi, Lioba Schroeter, Amrutha Patkunarajah, Kate Poole 831-symp 11:15 am STRUCTURE AND MECHANOGATING OF THE MECHANOSENSITIVE PIEZO CHANNEL.  Bailong Xiao 832-symp 11:45 am SENSING SCENTS: STRUCTURAL INSIGHTS INTO INSECT OLFACTORY RECEPTORS.  Vanessa Ruta 833-symp 12:15 pm SENSING SOUR: THE OTOP1 PROTON CHANNEL FROM FUNCTION TO STRUCTURE.  Emily Liman Symposium Biophysical Underpinnings of the Origin of Life 10:45 am - 12:45 pm, Ballroom 20D Chair Ken A. Dill, Stony Brook University 834-symp10:45 am LESSONS FROM EXPERIMENTAL PROTEIN FITNESS LANDSCAPES.  11:15 am RESURRECTED ENZYMES AS PROXIES FOR ANCIENT BIOMOLECULAR PROCESSES.  Betul Kacar 835-symp 11:45 am LESSONS FROM RIBOZYME EVOLUTION.  Irene Chen 836-symp 12:15 pm A CENTRAL ROLE FOR PEPTIDES AND PROTEINS IN THE CHEMISTRY TO BIOLOGY TRANSITION OF THE ORIGINS OF LIFE.  Ken Dill Daniel Bolon No Abstract

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