Biophysical Society 2020 Annual Meeting

Platform Cytoskeletal Motors 10:45 am - 12:45 pm, Room 25ABC

842-plat 12:00 pm FRET-BASED HIGH-THROUGHPUT SCREENING BIOSENSOR USING THE CARDIAC RYANODINE RECEPTOR (RYR2) N-TERMINAL “ABC” DOMAIN.  Jingyan Zhang , Robyn T. Rebbeck, David D. Thomas, Filip V. Petegem, Razvan L. Cornea 843-plat 12:15 pm Travel Awardee MECHANISMS OF MICU1 REGULATION OF THE MITOCHONDRIAL CAL- CIUM UNIPORTER COMPLEX.  Chen-Wei Tsai , Ming-Feng Tsai 844-plat 12:30 pm MECHANISMS OF EMRE ACTIVATION OF THE MITOCHONDRIAL CALCIUM UNIPORTER.  Anna M. Van Keuren , Chen-Wei Tsai, Ming-Feng Tsai Platform Biosensors 10:45 am - 12:45 pm, Room 24ABC Co-Chairs leyla Esfandiari, University of Cincinnati Yoo Jin Oh, Johannes Kepler University Linz, Austria 845-plat 10:45 am FORCE-CONTROLLED NANOPORES FOR SINGLE CELL MEASUREMENTS USING MICRO-CHANNELLED AFM CANTILEVERS.  Til Schlotter , Sean Weaver, Tomaso Zambelli, Janos Voros, Morteza Aramesh 846-plat 11:00 am DETECTION OF SINGLE PROTEINS IN A COMPLEX BIOFLUID USING A SELECTIVE NANOPORE: FINDING THE NEEDLE IN A HAYSTACK.  Avinash Thakur, Liviu Movileanu 847-plat 11:15 am ASSEMBLING A SINGLE-MOLECULE NANOPORE-NANOMACHINE TO UN- RAVEL THE INTERACTION BETWEEN ANTI-CANCER DRUGS WITH TARGET- ING DNAS.  Kai Tian , Chengrui Hou, Emily Ma, Binquan Luan, Li-Qun Gu 848-plat 11:30 am LABEL-FREE PROBING OF BINDING AFFINITY USING TOPOGRAPHY AND RECOGNITION IMAGING.  Yoo Jin Oh , Melanie Köhler, Yoonhee Lee, Sourav Mishra, Joon Won Park, Peter Hinterdorfer 849-plat 11:45 am PHOTOACOUSTIC SELECTIVE PLANE ILLUMINATION MICROSCOPY.  Francesco Garzella , Cristiano Viappiani, Ranieri Bizzarri, Barbara Storti, Stefania Abbruzzetti, Paolo Bianchini, Alberto Diaspro 850-plat 12:00 pm BIOPHYSICAL CHARACTERIZATION OF EXOSOMES BASED ON THEIR UNIQUE DIELECTRIC PROPERTIES.  Yuqian Zhang, Leilei Shi, Leyla Esfandiari 851-plat 12:15 pm IMPROVED SPLIT FLUORESCENT PROTEINS FOR THE VISUALIZATION OF ENDOGENOUS PROTEINS AND SYNAPSES.  Siyu Feng, Shuqin Zhou , Aruna Varshney, Doris C. Villa, Cyrus Modavi, John Kohler, Fatima Farah, Nebat Ali, Joachim D. Mueller, Miri VanHoven, Bo Huang 852-plat 12:30 pm SPATIALLY COMPARTMENTALIZED PHASE REGULATION IN THE CA 2+ - CAMP-PKA-OSCILLATORY CIRCUIT.  Brian Tenner , Michael Getz, Brian L. Ross, Donya Ohadi, SohumMehta, Padmini Rangamani, Jin Zhang

M O N D A Y

Co-Chairs Kumiko Hayashi, Tohoku University, Japan Jing Xu, University of California, Merced 853-plat 10:45 am

DYNACTIN P150 PROMOTES PROCESSIVE MOTILITY OF DDB COMPLEXES BY MINIMIZING DIFFUSIONAL BEHAVIOR OF DYNEIN.  Qingzhou Feng, Allison Gicking, William O. Hancock 854-plat 11:00 am EFFECT OF THE DYNEIN INHIBITOR CILIOBREVIN ON THE NUMBER OF FORCE PRODUCING UNITS TRANSPORTING SYNAPTIC VESICLE PRECUR- SORS.  Kumiko Hayashi , Miki G. Miyamoto, Shinsuke Niwa 855-plat 11:15 am STRUCTURE OF THE DYNEIN-2 COMPLEX AND ITS ASSEMBLY WITH IN- TRAFLAGELLAR TRANSPORT TRAINS.  Katerina Toropova 856-plat 11:30 am Travel Awardee CHEMO-MECHANICAL CYCLE DIVERSITY IN THE KINESIN SUPERFAMILY REVEALED BY CRYO-EM. Matthieu P. Benoit , Ana B. Asenjo, Moham- madjavad Paydar, Byron Hunter, John S. Allingham, Benjamin H. Kwok, Hernando Sosa 857-plat 11:45 am CHOLESTEROL IN THE CARGO MEMBRANE IMPACTS KINESIN-BASED TRANSPORT IN THE PRESENCE OF TAU.  Qiaochu Li, John O. Wilson, Kuo- fu Tseng, Weihong Qiu, Michael Vershinin, Stephen J. King, Jing Xu 858-plat 12:00 pm BRIDGING KINESIN PROPERTIES WITH SYSTEM-SCALE CHARACTERISTICS OF MICROTUBULE-MOTOR ASSEMBLIES.  Rachel Banks , Heun Jin Lee, Tyler Ross, Matt Thomson, Rob Phillips 859-plat 12:15 pm BETA-CARDIAC MYOSIN WITH AN HCMMUTATION (R712L) HAS AN IN- HIBITED WORKING STROKE THAT IS RESCUED BY THE DRUG OMECAMTIV MECARBIL.  Aaron Snoberger , Bipasha Barua, Jennifer L. Atherton, Eva Forgacs, Yale E. Goldman, Donald A. Winkelmann, E. Michael Ostap 860-plat 12:30 pm FRET AND OPTICAL TRAPPING MEASUREMENTS REVEAL RELATIONSHIP BETWEEN PHOSPHATE RELEASE AND THE POWER STROKE IN MYOSIN V.  Edward P. Debold, Laura K. Gunther, Matthew Unger, Brent Scott, Wanjian Tang, Christopher M. Yengo Platform Membrane Protein Dynamics and Folding II 10:45 am - 12:45 pm, Room 30ABC Co-Chairs Konstantina Karathanou, Freie Universität Berlin, Germany Katherine Schaefer, University of Missouri 861-plat 10:45 am DIRECT OBSERVATION OF LIGAND-INDUCED CONFORMATIONAL CHANG- ES OF P-GLYCOPROTEIN IN AFM AND CORRELATION WITH SURFACE- ABSORBED ACTIVITY MEASUREMENTS.  Katherine G. Schaefer , Gershon Mensah, Phuong H. Nguyen, Arthur G. Roberts, Gavin M. King 862-plat 11:00 am REVEALING A MULTISTEP BINDING MECHANISM OF INSERTASES FOR MEMBRANE PROTEIN INSERTION AND FOLDING.  Pawel R. Laskowski , Kristyna Pluhackova, Brian M. Lang, Andreas Kuhn, Daniel J. Mueller

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