Biophysical Society 59th Annual Meeting Program Guide

1784-P lat 11:45 am ELECTROMAGNETIC TWEEZERS WITH INDEPENDENT FORCE AND TORQUE CONTROL. Chang Jiang , Troy A. Lionberger, Diane M. Wiener, Edgar Meyhöfer 1785-P lat 12:00 pm SURFACE-FREE SINGLE-MOLECULE FORCE SPECTROSCOPY. Yan Jiang , Wesley Wong 1786-P lat 12:15 pm HIGH-SPEED FORCE SPECTROSCOPY UNBINDS STREPTAVIDIN-BIOTIN AT THE VELOCITY OF MOLECULAR DYNAMICS SIMULATIONS. Felix Rico , Andreas Russek, Helmut Grubmueller, Simon Scheuring 1787-P lat 12:30 pm THE PRINCESS AND THE PEA: A STORY OF CELL MECHANICS. Mehdi Roeinpeikar , Qian Xu, Xuefeng Wang, Taekjip Ha 10:45 am –12:45 pm , R oom 316/317 Platform Protein-Small Molecule Interactions Co-Chairs Jürgen Bosch, Johns Hopkins University Sonya Hanson, Memorial Sloan Kettering Cancer Center 1788-P lat 10:45 am BIASING POTENTIAL REPLICA EXCHANGE MULTI-SITE λ -DYNAMICS FOR EFFICIENT FREE ENERGY CALCULATIONS OF PROTEIN-LIGAND INTERACTIONS. Kira A. Armacost , Garrett B. Goh, Charles L. Brooks 1789-P lat 11:00 am SURVEY OF PHOSPHORYLATION NEAR DRUG BINDING SITES IN THE PROTEIN DATA BANK (PDB) AND THEIR EFFECTS. Kyle P. Smith , Kathleen M. Gifford, Joshua S. Waitzman, Sarah E. Rice 1790-P lat 11:15 am education travel awardee IDENTIFICATION AND CHARACTERIZATION OF PROTEIN- PROTEIN INTERACTION EFFECTORS TARGETING THE INVASION MACHINERY OF THE MALARIA PARASITE. Lauren E. Boucher , Christine S. Hopp, Photini Sinnis, Jürgen Bosch 1791-P lat 11:30 am ABSOLUTE BINDING FREE ENERGY CALCULATIONS OF BROMODOMAIN INHIBITORS. Matteo Aldeghi , Stefan Knapp, Alexander Heifetz, John J. Barker, Michael J. Bodkin, Richard J. Law, Philip C. Biggin 1792-P lat 11:45 am POSITIVE MODULATORS OF GLYCINE RECEPTORS WITH ANALGESIC POTENTIAL IDENTIFIED BY VIRTUAL SCREENING. Marta M. Wells , David D. Mowrey, Edom Seyoum, Tianmo Sun, Yan Xu, Pei Tang 1793-P lat 12:00 pm GREEN AND BLACK TEA POLYPHENOLS MECHANISTICALLY INHIBIT THE AGGREGATION OF AMYLOID- β IN ALZHEIMER’S DISEASE. Shelby E. Chastain , Melissa Moss 1794-P lat 12:15 pm EFFECT OF REACTIVE ALDEHYDES ON IONOPHORE- MEDIATED TRANSMEMBRANE TRANSLOCATIONS OF H + AND K + . Alina A. Pashkovskaya , Elena E. Pohl

1795-P lat 12:30 pm DEVELOPING HIGH-THROUGHPUT FLUORESCENCE-BASED ASSAYS FOR MEASURING KINASE INHIBITOR FREE ENERGIES OF BINDING. Sonya M. Hanson , Jan-Hendrik Prinz, Julie M. Behr, Patrick B. Grinaway, Arien S. Rustenburg, Kyle A. Beauchamp, Daniel L. Parton, John D. Chodera 12:00 pm –1:30 pm , R oom 331/332 Funding Opportunities for Faculty at Primarily Undergraduate Institutions The Education Committee is hosting this session aimed at helping PUI faculty find funding sources that will help them to establish or maintain an active and productive undergraduate research laboratory. Speakers This question-and-answer luncheon, sponsored by the Committee for Professional Opportunities for Women (CPOW), is designed for postdocs finishing and actively applying for academic faculty positions. New faculty and recently tenured faculty in basic science and/or medical school departments will lead the discussion, as well as experienced senior-level faculty who have served as department chairs and/or part of faculty search committees. Topics for discussion include how to prepare the curriculum vitae, the interview process, networking, how to negotiate the job offer, and advice for new faculty as they balance research with their department obligations. Pre-registration was required for lunch. If you are interested in attending and did not register in advance, you are welcome to participate in the discussion on a space-available basis. Speakers Sarah Bondos, Texas A&M Health Science Center Jane Clarke, University of Cambridge, United Kingdom Barry Grant, University of Michigan Anne Hinderliter, University of Minnesota, Duluth Rohit Pappu, Washington University, St. Louis Catherine Royer, Rensselaer Polytechnic Institute Madeline Shea, University of Iowa Carver College of Medicine Shai Silberberg, NIH/NINDS Joanna Sulkowska, University of Warsaw, Poland 12:30 pm –2:00 pm , H all C, R oom B Exhibitor Presentation Nanion Technologies GmbH Measure More Membrane: Cells, Bilayers and Transporter Activity The Port-a-Patch turned 10 years old last year, and is going stronger than ever. It’s still the smallest patch clamp rig in the world, and makes patch clamp recordings accessible to anyone spending a couple of hours with it. Giga-seal recordings and the excellent voltage-clamp of the cellular membrane ensure high quality data, and the Port-a-Patch add-ons allow unprecedented experimental freedom, including temperature control, internal perfusion, automated action potential recordings, and recordings from primary and stem cell-derived cells. The Orbit 16 is a parallel device for efficient formation of and recordings from up to 16 artificial bilayers at once, for parallel bilayer-reconstitution of ion channels and nanopores. Using Micro Electrode Cavity Array (MECA, Ionera), a 4 x 4 array of circular micro-cavities in a highly inert polymer, the bilayer is automatically formed by remotely actuated painting (Ionera- SPREAD), which all will be demonstrated during the session. Jean Chin, NIGMS Kamal Shukla, NSF 12:00 pm –2:00 pm , R oom 318/319 Postdoc to Faculty Q&A: Transitions Forum and Luncheon

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland