Biophysical Society 59th Annual Meeting Program Guide

Ion transporters and pumps play an important role within general metabolism and information processing of organisms. The SURFE2R is a unique platform for direct measurements ion transporters and ion channels in diverse and heterologous membranes. It is easy-to-handle, highly sensitive and a very efficient screening platform. The SURFE2R N1 is a small footprint, fully automated device recording from membrane preparations, with proven success using native tissue, mammalian and insect cell lines, bacteria, organelles, and proteoliposomes. Join this workshop for hands-on experiments and information about three outstanding platforms: Port-a-Patch, Orbit 16 and SURFE2R N1! We look forward to seeing you! Spaces are limited so reserve yours by sending an email to info@nanion.de. Presenters Andrea Brüggemann, CSO, Nanion Technologies GmbH Maria Barthmes, Application Specialist, Nanion Technologies GmbH Gerhard Baaken, CEO, Ionera 1:00 pm –3:00 pm , H all C Industry and Agency Opportunities Fair This fair will introduce attendees to companies and agencies that have employment and funding opportunities outside of academia. Stop by the fair to learn about the variety of opportunities available to scientists in industry and government and to talk one-on-one with representatives from participating organizations. Don’t forget to check out the Career Center, Room 301/302/303, for current job prospects offered by many of the participating organizations. 1:30 pm –3:00 pm , H all C, R oom A Exhibitor Presentation KinTek Corporation KinTek Explorer Software: New Advances in Fitting Kinetic and Equilibrium Data Fitting kinetic data based upon numerical integration of rate equations offers many advantages over conventional fitting of data based upon equations derived from simple models. Fitting by simulation is the most rigorous and eliminates numerous errors in simplifying assumptions needed to derive equations. Every day papers are published that contain errors in kinetic analysis that could have been avoided if the data had been fit using KinTek Explorer software. In this presentation, Dr. Johnson will show how global fitting of kinetic data can be accomplished with ease using the fast, dynamic simulation in KinTek Explorer software, overcoming the all-to-common errors in conventional fitting. Moreover, data are fit to derive rate constants directly defining steps in a model, not merely observed rates (Eigenvalues). New advances in the software allow fitting kinetic data from single molecule experiments and families of curves can be fit simultaneous to define voltage-dependent rate constants or data from Temperature-jump or Pressure-jump experiments. In addition, equilibrium titration data can be fit using a unique endpoint simulation method, and time-resolved spectra can be fit using singular value decomposition (SVD). All experiments can be fit simultaneously and accurate error estimates are derived using robust confidence contour analysis. Presenters Kenneth A. Johnson, President, KinTek Corporation Roger Williams, Professor of Biochemistry, University of Texas at Austin

1:30 pm –2:30 pm , R oom 309/310 Conversation with NIGMS Director Jon Lorsch

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Jon Lorsch assumed the role of Director of the National Institute of General Medical Sciences in 2013. One year in, he is leading a five-year strategic planning effort at NIH for the Institute and examining how the Institute can make the most of its resources to support fundamental research. Come to this session to learn more about Lorsch’s vision for NIGMS as well as what is new at the Institute. 1:45 pm –3:00 pm , H all C Snack Break 2:30 pm –3:30 pm , R oom 301/302/303 Career Center Workshop Ten Tough Industrial Interview Questions (and Ten Pretty Good Responses) You’ve been invited to interview with that drug development company that you’ve always wanted to work for. You’ve soaked up the details of the position description. You are confident in your ability to do the job, as well as answer any/all technical questions during the interview process. The day is yours…until…that first question catches you by surprise and your confidence begins to wilt. Be prepared for those non-technical questions that you will almost certainly hear at some point, know why they are asked, and learn what a good (if not great) response to each question might be by attending this workshop. 2:30 pm –4:30 pm , R oom 330 Grant Opportunities for Early Career Faculty In this panel, hosted by the Early Careers Committee, program coordinators and research administrators from key funding agencies will discuss and answer questions about the timeline, strategies, and funding opportunities for new faculty working to establish their independent laboratories. Speakers Bishow Adhikari, NIH Beth Schachter, Beth Schachter Consulting Kamal Shukla, NSF 3:00 pm –4:00 pm , R oom 327/328/329 Networking with Minority Biophysicists: Resources and Opportunities This networking event, sponsored by the Minority Affairs Committee, provides minority students and scientists the opportunity to network and discuss challenges and resources with other minority biophysicists. 3:00 pm –5:00 pm , R oom 333 Education Committee Meeting 4:00 pm –6:00 pm , B allroom I Symposium Nanoclustering of Membranes and Membrane Proteins Chair Ka Yee Lee, University of Chicago 1796-S ymp 4:00 pm STRUCTURE AND FUNCTION OF MEMBRANE-REMODELING ESCRT-III ASSEMBLIES. John McCullough, Marissa Saunders, Leremy Colf, Wes Sundquist, Adam Frost

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland