Biophysical Society 59th Annual Meeting Program Guide

1817-P lat 5:15 pm MYOSIN-BINDING PROTEIN C CORRECTS AN INTRINSIC NON-UNIFORMITY IN CARDIAC EXCITATION- CONTRACTION COUPLING. Michael J. Previs , Benjamin L. Prosser, Ji Young Mun, Samantha Beck Previs, James Gulick, Kyounghwan Lee, Jeffrey Robbins, Roger Craig, W. Jonathan Lederer, David M. Warshaw 1818-P lat 5:30 pm DIRECT DETECTION OF THE THERMODYNAMICS AND STRUCTURAL KINETICS OF A 2-COLOR SERCA BIOSENSOR BY TRANSIENT TIME-RESOLVED FRET. Simon J. Gruber, Rebecca Goldblum , Jenica Zhong, Kurt Peterson, Tory M. Schaaf, Joseph M. Autry, Gregory D. Gillispie, David D. Thomas, Joseph M. Muretta 1819-P lat 5:45 pm PHOSPHOLAMBAN-INDEPENDENT ADRENERGIC RESERVE IN SERCA2 ABLATED HEARTS. Frazer I. Heinis , Joseph M. Metzger Co-Chairs James Munro, Tufts University Joana Paulino, Florida State University 1820-P lat 4:00 pm CONFORMATIONAL DYNAMICS OF SINGLE HIV-1 ENVELOPE PROTEINS ON THE SURFACE OF NATIVE VIRIONS. James B. Munro , Jason Gorman, Xiaochu Ma, Zhou Zhou, James Arthos, Dennis Burton, Wayne Koff, Joel Courter, Amos Smith, Peter Kwong, Scott Blanchard, Walther Mothes 1821-P lat 4:15 pm ALLOSTERIC REGULATION OF NIPAH VIRUS ENTRY INTO HOST CELLS. Sameer Varma , Priyanka Dutta, Mohsen Botlani 1822-P lat 4:30 pm SPECIFIC PROTEIN-LIPID INTERACTIONS STABILIZE AN ACTIVE STATE OF THE BETA 2 ADRENERGIC RECEPTOR. Chris Neale , Henry D. Herce, Régis Pomès, Angel E. García 1823-P lat 4:45 pm DYNAMICS OF M2 PROTON CHANNEL: INSIGHTS INTO THE MOTIONS OF THE PRIMARY AND SECONDARY GATES. Joana Paulino , Ivan Hung, Timothy A. Cross 1824-P lat 5:00 pm IDENTIFICATION OF AN ENDOGENOUS ALLOSTERIC MODULATOR’S BINDING SITE AT THE HUMAN CANNABINOID-1 RECEPTOR, USING FORCED-BIASED METROPOLIS MONTE CARLO SIMULATED ANNEALING METHOD (MMC) AND MOLECULAR DYNAMICS. Derek M. Shore , Dow P. Hurst, Diane L. Lynch, Patricia H. Reggio 1825-P lat 5:15 pm LIGAND-G PROTEIN ALLOSTERIC COMMUNICATION THROUGH INTERNAL WATERS IN GPCR COMPLEXES. Roman Osman , Jose Carlos Gomez, Mihaly Mezei, Dov Barak, Arnau Cordomi, Leonardo Pardo 1826-P lat 5:30 pm INSERTION OF β -BARREL PROTEINS IN GRAM-NEGATIVE BACTERIA. Karl Lundquist , James C. Gumbart 4:00 pm –6:00 pm , R oom 307/308 Platform Protein Dynamics and Allostery II

1827-P lat 5:45 pm SUPER-RESOLUTION MAPPING OF THE DYNAMICS OF PERIODIC STRUCTURAL DEFECTS IN COLLAGEN FIBRILS. Andrew Dittmore , Jonathan Silver, Barry Marmer, Gregory I. Goldberg, Keir C. Neuman

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4:00 pm –6:00 pm , R oom 309/310 Platform Systems Biophysics

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Co-Chairs Cees Decker, Delft University of Technology, The Netherlands Hye Ran Koh, University of Illinois at Urbana-Champaign 1828-P lat 4:00 pm SYMMETRY AND SCALE ORIENT MIN OSCILLATION PATTERNS IN BACTERIAL SHAPE SCULPTURES. Fabai Wu, bas van Schie, Juan Keymer, Cees Dekker 1829-P lat 4:15 pm QUANTITATIVE ANALYSIS OF RNA INTERFERENCE BY MRNA COUTING AT SINGLE-CELL LEVEL. Hye Ran Koh , Sua Myong 1830-P lat 4:30 pm ENVIRONMENTAL STATISTICS AND OPTIMAL REGULATION. David A. Sivak , Matt Thomson 1831-P lat 4:45 pm FUNDAMENTAL CONSTRAINTS ON THE ABUNDANCES OF CHEMOTAXIS PROTEINS. Anne-Florence Bitbol , Ned S. Wingreen 1832-P lat 5:00 pm EARLY LINEAGE BIFURCATION DURING DIFFERENTIATION OF EMBRYONIC STEM CELLS REVEALED BY SINGLE-CELL TRANSCRIPTOMICS. Stefan Semrau , Johanna Goldmann, Magali Soumillon, Tarjei Mikkelsen, Rudolf Jaenisch, Alexander van 5:15 pm EMERGENT BEHAVIOURS OF STEM CELLS IN ORGANOGENESIS DEMONSTRATED BY HYBRID MODELLING. Benjamin A. Hall , Nir Piterman, Alex Hajnal, Jasmin Fisher 1834-P lat 5:30 pm PHAGE DNA DYNAMICS IN CORRELATION WITH CELL FATES. Qiuyan Shao, Alexander Hawkins, Lanying Zeng 1835-P lat 5:45 pm SYSTEMS MECHANO-BIOLOGY: TENSION-INHIBITED PROTEIN TURNOVER IS SUFFICIENT TO PHYSICALLY CONTROL GENE CIRCUITS. P. C. Dave P. Dingal , Dennis E. Discher Oudenaarden 1833-P lat

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4:00 pm –6:00 pm , R oom 314/315 Platform Ion Channel Regulatory Mechanisms

Co-Chairs Takanari Inove, Johns Hopkins University Michelle Yen, Stanford University 1836-P lat 4:00 pm COUPLING OF DISTINCT ION CHANNEL TYPES IN NEURONS MEDIATED BY AKAP79/150. Jie Zhang, Mark S. Shapiro

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland