Biophysical Society 59th Annual Meeting Program Guide

60-P lat 8:15 am ROLE OF DESOLVATION IN THERMODYNAMICS AND KINETICS OF LIGAND BINDING TO A PROTEIN. Jagannath Mondal , Richard Friesner, Bruce J. Berne 61-P lat 8:30 am INSIGHTS INTO THE STABILIZING ROLE OF CHOLESTEROL FOR THE AMYLOID PRECURSOR PROTEIN. Martina Audagnotto , Matteo Dal Peraro 62-P lat 8:45 am PHARMACOPHORE MODELING USING SITE- IDENTIFICATION BY LIGAND COMPETITIVE SATURATION (SILCS) METHOD WITH MULTIPLE PROBE MOLECULES. Wenbo Yu , E. Prabhu Raman, Sirish Kaushik Lakkaraju, Lei Fang, Alexander D. MacKerell Jr. 63-P lat 9:00 am QUANTIFYING MACROMOLECULAR CONFORMATIONAL TRANSITION PATHWAYS. Oliver Beckstein , Sean L. Seyler, Avishek Kumar, Michael F. Thorpe 64-P lat 9:15 am COMPUTATIONAL DESIGN OF REPEAT-PROTEINS WITH A PREDEFINED GEOMETRY. Sebastian Rämisch , Ulrich Weininger, Jonas Martnisson, Mikael Akke, Ingemar André 65-P lat 9:30 am COMPUTATIONAL PREDICTION OF G-QUADRUPLEX FORMATION. Jacob S. Calvert , Alex Kreig, Saurabh Sinha, Sua Myong 66-P lat 9:45 am PROTEIN AND RNA STRUCTURE PREDICTION BY INTEGRATION OF CO-EVOLUTIONARY INFORMATION INTO MOLECULAR SIMULATION. Eleonora De Leonardis, Benjamin Lutz, Simona Cocco, Remi Monasson, Hendrik Szurmant, Martin Weigt, Alexander Schug 67-P lat 10:00 am STRUCTURAL ENSEMBLES OF INTRINSICALLY DISORDERED PROTEINS USING MOLECULAR DYNAMICS SIMULATION. Sarah Rauscher , Vytautas Gapsys, Bert de Groot, Helmut Grubmüller Co-Chairs Svea Grieb, Technical University of Dresden, Germany Beat Fierz, École Polytechnique Fédérale de Lausanne, Switzerland 68-P lat 8:15 am BINDING COMPETITION STUDIED WITH SINGLE MOLECULE FRET: THE INTEGRON RECOMBINASE OUTCOMPETES THE SINGLE-STRANDED DNA BINDING PROTEIN FOR ITS RECOMBINATION SITE. M. Svea Grieb , Varsha Natarajan, Marko Swoboda, Michael Schlierf 69-P lat 8:30 am SINGLE-MOLECULE FRET FOR DYNAMIC STRUCTURAL BIOLOGY: DNA POLYMERASE I STRUCTURE AND MECHANISM WITH ANGSTROM PRECISION. Marko Sustarsic , Timothy Craggs, Johannes Hohlbein, Andrew Cuthbert, Nicholas Taylor, Hendrik Kaju, Majid Mosayebi, Jonathan Doye, Achillefs N. Kapanidis 70-P lat 8:45 am HETEROCHROMATIN ASSEMBLY AND DYNAMICS ON THE SINGLE MOLECULE LEVEL. Sinan Kilic, Bachmann Andreas, Louise Bryan, Beat Fierz 8:15 am –10:15 am , B allroom IV Platform Protein-Nucleic Acid Interactions I

71-P lat 9:00 am RNA UNWINDING BY THE HELICASE MTR4P AND THE TRAMP COMPLEX INVESTIGATED VIA HIGH-RESOLUTION OPTICAL TRAPPING. Eric M. Patrick , Sukanya Srinivasan, Eckhard Jankowsky, Matthew J. Comstock 72-P lat 9:15 am ELECTROSTATIC INTERACTION EFFECTS ON THE BINDING OF SPLICEOSOMAL U1A PROTEIN-SL2 RNA HAIRPIN. Zhaleh Ghaemi , Irisbel Guzman, Martin Gruebele, Zaida Luthey- 9:30 am CHROMOSOME REORGANIZATION BY THE HIGHLY COOPERATIVE DPS PROTEIN. Natalia Vtyurina , David Dulin, Margreet Docter, Nynke Dekker, Anne Meyer, Elio Abbondanzieri 74-P lat 9:45 am ASYMMETRIC NUCLEOSOME DISASSEMBLY WITH DISRUPTED HISTONES REVEALED BY TIME RESOLVED SMALL ANGLE X-RAY SCATTERING WITH CONTRAST VARIATION. Yujie Chen , Joshua M. Tokuda, Traci Topping, Julie L. Sutton, Steve P. Meisburger, Suzette A. Pabit, Lisa M. Gloss, Lois Pollack 75-P lat 10:00 am UNDERSTANDING WITHOUT READING: ANALOGUE ENCODING OF PHYSICOCHEMICAL PROPERTIES OF PROTEINS IN THEIR COGNATE MESSENGER RNA. Anton A. Polyansky , Mario Hlevnjak, Bojan Zagrovic Schulten 73-P lat

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8:15 am –10:15 am , R oom 307/308 Platform Protein Structure and Conformation I

Co-Chairs Silvina Matysiak, University of Maryland Michelle Peckham, University of Leeds, United Kingdom 76-P lat 8:15 am ROLE OF INTERFACES IN PEPTIDE FOLDING AND AGGREGATION. Sai Janani Ganesan , Silvina Matysiak 77-P lat 8:30 am

COMBINING NEUTRON REFLECTIVITY AND HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY TO RESOLVE STRUCTURAL DETAILS OF MEMBRANE ASSOCIATED PROTEINS. Michael S. Kent , Bulent Akgun, Hirsh Nanda, Gregory F. Pirrone, John Engen 78-P lat 8:45 am international travel awardee EFFECT OF MOLECULAR CROWDING ON THE STRUCTURE AND DYNAMICS OF HUMAN APO AND HOLO TRANSFERRIN USING 2D-IR CORRELATION SPECTROSCOPY. Sherif Abbas , Feride Severcan, Parvez I. Haris 79-P lat 9:00 am STRUCTURAL INSIGHT INTO THE PHOSPHOINOSITIDE- REGULATED CELLULAR DYNAMICS OF ALPHA-ACTININ. Andrea Ghisleni , Euripides De Almeida Ribeiro, Nikos Pinotsis, Mark R. Holt, Pauline Bennett, Kristina Djinovic-Carugo, Mathias Gautel 80-P lat 9:15 am DETERMINING HOW MANY IONIC INTERACTIONS ARE NEEDED FOR THE HIGH STABILITY OF SINGLE ALPHA HELICAL (SAH) DOMAINS. Marcin D. Wolny, Matthew R. Batchelor, Peter J. Knight, Emanuele Paci, Michelle Peckham

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland