Biophysical Society 59th Annual Meeting Program Guide

2684-P os B oard B114 REGULATION OF THE MOLECULAR BRAKE REGION IN FGFR2 KINASE. Jerome M. Karp , David Cowburn 2685-P os B oard B115 PKA VALUES OF BURIED GROUPS IN PROTEINS ARE SENSITIVE TO THE GLOBAL THERMODYNAMIC STABILITY. Jaime L. Sorenson , Raidizon Mercedes, Jamie L. Schlessman, Bertrand García-Moreno 2686-P os B oard B116 CRITICAL ROLE OF A GLYCINE RESIDUE IN AN ALLOSTERIC SWITCH. Dorothy Beckett, William Cressman Enzymes and Protein Dynamics II (Boards B117-B134) 2687-P os B oard B117 ZINC INHIBITS HEDGEHOG AUTOPROCESSING:LINKING ZINC DEFICIENCY WITH HEDGEHOG ACTIVATION. Jian Xie , Timothy Owen, Ke Xia, Ajay Vikram Singh, Emiley Tou, Lingyun Li, Leo Q. Wan, Brian Callahan, Chunyu Wang 2688-P os B oard B118 PROBING FACTOR XIII SUBSTRATE SPECIFICITY FOR FIBRINOGEN α C (233-425) USING MALDI-TOF MASS SPECTROMETRY AND 2D 15N-1H HSQC NMR SPECTROSCOPY. Kelly Njine Mouapi , Jacob Bell, Kerrie Smith, Helen Philippou, Robert Ariens, Muriel Maurer 2689-P os B oard B119 LIGAND BINDING TO ANION BINDING EXOSITES AS PROTHROMBIN IS CONVERTED TO ACTIVE THROMBIN. Ramya Billur , Marina V. Malovichko, Muriel C. Maurer 2690-P os B oard B120 MOLECULAR DYNAMICS STUDIES OF THE UBIQUITIN CONJUGATION MECHANISM. Serban Zamfir 2691-P os B oard B121 PROTEOLYSIS OF ABNORMAL PRION PROTEIN WITH A THERMOSTABLE PROTEASE FROM A HYPER-THERMOPHILIC ARCHAEON THERMOCOCCUS KODAKARENSIS KOD1. Yuichi Koga , Nami Shimizu, Akikazu Sakudo, Shigenori Kanaya 2692-P os B oard B122 KINETIC CHARACTERIZATION OF HUMAN LIVER PHOSPHOFRUCTOKINASE. Amanda Tindall , Gregory D. Reinhart 2693-P os B oard B123 USE OF 2-PHOTON FLUORESCENCE CORRELATION SPECTROSCOPY AND ELECTRON MICROSCOPY TO ELLUCIDATE THE DEPENDENCE OF RLPFK SELF ASSOCIATION ON LIGAND CONCENTRATION. David Holland , Jeng-Yih Chang, Junjie Zhang, Gregory D. Reinhart 2694-P os B oard B124 THE ISOLATED LARGE SUBUNIT OF E. COLI CARBAMOYLPHOSPHATE SYNTHETASE DEVIATES FROM KINETIC MECHANISM AND ALLOSTERIC BEHAVIOR OF THE HOLOENZYME. Robert Koenig , Gregory D. Reinhart 2695-P os B oard B125 FREE-ENERGY LANDSCAPES OF THE TRANSLOCATION OF A SUBSTRATE IN FOUR PROTEASOME - ACTIVATOR COMPLEXES ANALYZED USING MOLECULAR DYNAMICS SIMULATIONS. Hisashi Ishida

2672-P os B oard B102 GEOMETRIC DESCRIPTION OF DYNAMIN INDUCED MEMBRANE FISSION. Pablo Vázquez-Montejo, Zachary McDargh , Markus Deserno 2673-P os B oard B103 TWO PATHWAYS MEDIATE INTER-DOMAIN ALLOSTERIC REGULATION IN PIN1. Jingjing Guo , Xiaodong Pang, Huan-Xiang Zhou 2674-P os B oard B104 THE IMPACT OF PERTURBING DYNAMIC AMINO ACID NETWORKS IN A ( β / α )8 BARREL ENZYME. Kathleen F. O’Rourke , Jennifer M. Axe, Nicole E. Kerstetter, David D. Boehr 2675-P os B oard B105 CONFORMATIONAL EXCHANGE COUPLED TO IONIZATION OF LYS RESIDUES BURIED IN HYDROPHOBIC ENVIRONMENTS IN PROTEINS. Daniel E. Richman , Ananya Majumdar, Bertrand Garcia-Moreno 2676-P os B oard B106 NMR INVESTIGATION OF ENERGY BARRIERS FOR HYDROGEN-BOND BREAKAGE OF PROTEIN SIDE-CHAIN NH3+ GROUPS. Levani Zandarashvili , Junji Iwahara 2677-P os B oard B107 THUMB II SITE INHIBITOR ALLOSTERICALLY SUPPRESSES THE DYNAMICS OF HCV RNA-DEPENDENT RNA POLYMERASE. Daniel J. Deredge , Kenneth Johnson, Patrick Wintrode 2678-P os B oard B108 DYSFUNCTIONAL CONFORMATIONAL DYNAMICS OF PROTEIN KINASE A FROM R14 DELETION OF PHOSPHOLAMBAN. Jonggul Kim , Larry R. Masterson, Alessandro Cembran, Raffaello Verardi, Lei Shi, Jiali Gao, Gianluigi Veglia 2679-P os B oard B109 DYNAMICAL X-RAY SINGLE MOLECULE OBSERVATIONS OF THE MOLECULAR RECOGNITION PROCESS IN MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE. Toshihiro Miyabe , Yufuku Matsushita, Kosuke Kasadera, Yuko Kozono, Hiroshi Sekiguchi, Keigo Ikezaki, Haruo Kozono, Yuji C. Sasaki 2680-P os B oard B110 UNEXPECTED VASP-EVH1 INTERACTIONS WITH IRAK1 AND ZYXIN: PHOSPHORYLATION AND BIVALENT BINDING. Lucila A. Acevedo , Alex I. Greenwood, Jeahoo Kwon, Kun P. Lu, Linda K. Nicholson 2681-P os B oard B111 INFLUENCE OF RNA BINDING ON THE CONFORMATIONAL DYNAMICS OF THE LASSA VIRUS NUCLEOPROTEIN. Jason Pattis , Eric R. May 2682-P os B oard B112 SITE-SPECIFIC CONFORMATIONAL DIVERSITY IN CALMODULIN USING CYANYLATED CYSTEINE VIBRATIONAL PROBES ALONG ITS BINDING INTERFACES. Kristen L. Kelly , Rebecca Wai, Kanika Ramchandani, Casey Londergan 2683-P os B oard B113 BACKBONE FLEXIBILITY AS A DETERMINANT OF PKA VALUES OF BURIED IONIZABLE GROUPS IN PROTEINS. Bertrand Garcia-Moreno , Gabrieal Ortega, Meredith T. Peck, Aaron Robinson, Jamie L. Schlessman

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland