Biophysical Society 59th Annual Meeting Program Guide

612-P os B oard B392 MUTATIONS IN THE S4/S5 LINKER AND S6 OF SLO1 ABLATE THE RESPONSE TO THE NOVEL BK CHANNEL OPENER GOSLO-SR-5-6. Arvind Kshatri , Tim I. Webb, Roddy J. Large, Adebola Morayo Akande, Subhrangsu Roy, Gerard P. Sergeant, Noel G. McHale, Keith D. Thornbury, Mark A. Hollywood TRP Channels I (Boards B393-B408) 613-P os B oard B393 A MECHANISM FOR DETECTING THE RATE OF TEMPERATURE CHANGE IN DROSOPHILA. Junjie Luo , Wei L. Shen, Craig Montell 614-P os B oard B394 ELECTROPHYSIOLOGICAL CHARACTERIZATION OF INTERNAL AND EXTERNAL LIGANDS ON TRPA1. Andrea Bruggemann , Markus Rapedius, Tom Götze, Claudia Haarmann, Ilka Rinke, Marius Vogel, Timo Stengel, Johannes Stiehler, Michael George, Niels Fertig 615-P os B oard B395 COOLING DOWN TRP CHANNEL: COLD AND CHEMO- SENSITIVITY OF THE HUMAN TRPA1. Mohamed Kreir , Lavanya Moparthi, Edward D. Högestätt, Urban Johanson, Andrea Bruggemann, Peter M. Zygmunt, Niels Fertig 616-P os B oard B396 THE ROLE OF TRPA1 AND TRPV1 CHANNELS IN OROFACIAL PAIN. Roberta Gualdani , Stefania Ceruti, Giulia Magni, Davide Merli, Lorenzo di Cesare Mannelli, Oscar Francesconi, Barbara Richichi, Giancarlo la Marca, Carla Ghelardini, Maria Rosa Moncelli, Cristina Nativi 617-P os B oard B397 PROBING TEMPERATURE SENSING OF THERMAL TRP CHANNELS BY CALORIMETRY. Kiran Andra , Anoop Saxena, Beiying Liu, Feng Qin 618-P os B oard B398 ROLE OF TRPV1 CHANNELS IN GLIOMA CELL VIABILITY AND SURVIVAL. Yelena Nersesyan , Swapna Asuthkar, Kiran K. Velpula, Xiaohui Sun, Lusine Demirkhanyan, Eleonora Zakharian 619-P os B oard B399 DIETARY CAPSAICIN AND EXERCISE: ANALYSIS OF A TWO- PRONGED APPROACH TO COUNTERACT OBESITY. Vivek Krishnan , Kevin Fettel, Baskaran Thyagarajan 620-P os B oard B400 PROTON AS A DUAL REGULATOR FOR TRPV1. Bo Hyun Lee , Jie Zheng 621-P os B oard B401 UNRAVELING ALLOSTERIC COUPLING MECHANISMS IN THE TRPV1 CHANNEL. Andrés Jara-Oseguera , Kenton J. Swartz 622-P os B oard B402 MOLECULAR MECHANISM OF TRPV1 ACTIVATION BY CAPSAICIN. Fan Yang, Xian Xiao , Wei Cheng, Wei Yang, Vladimir Yarov-Yarovoy, Jie Zheng 623-P os B oard B403 INSIGHT INTO THE STRUCTURE OF TETRAMER HTRPV1 FROM HOMOLOGY MODELING, MOLECULAR DOCKING, MOLECULAR DYNAMICS SIMULATION AND VIRTUAL SCREENING. Zhiwei Feng

624-P os B oard B404 THE MOLECULAR DETERMINANTS OF PI(4,5)P2 BINDING TO TRPV1 CHANNELS. Horacio Poblete , Ingrid Oyarzún, Pablo Olivero, Jeffrey Comer, Matías Zuñiga, Romina Sepulveda, David Báez-Nieto, Carlos González, Ferando Gonzalez-Nilo, Ramón Latorre 625-P os B oard B405 PREPARATION AND EVALUATION OF PLGA COATED CAPSAICIN MAGNETIC NANOPARTICLES FOR TARGET SITE- SPECIFIC PAIN THERAPEUTICS. Mrudhula Baskaran , Baskaran Thyagarajan 626-P os B oard B406 DISSOCIATION RATES AS ONE OF THE DIFFERENTIATING FACTORS FOR HYPERTHERMIC AND NON-HYPERTHERMIC TRPV1 ANTAGONISTS. Laykea Tafesse , Gang Wu, Kevin Carlin, Toshiyuki Asaki, Toshiyuki Kanemasa, Victor Ilyin 627-P os B oard B407 A SINGLE-RESIDUE SWITCH FOR HIGH TEMPERATURE DEPENDENCE OF THERMAL TRPV3 CHANNELS. Beiying Liu , B oard B408 THE SPIDER TOXIN GSMTX-4 BLOCKS TRPV4 CATION CHANNELS EXPRESSED IN HEK-293 CELLS. Christian SJ Kesselring, Mirjam Krautwald, Yaxin Zhang, Heinrich Brinkmeier Ion Channel Regulatory Mechanisms I (Boards B409-B427) 629-P os B oard B409 USE-DEPENDENT ACTIVATION OF NEURONAL KV1.2 CHANNEL COMPLEXES. Victoria A. Baronas , Brandon R. McGuinness, Yury Y. Vilin, Robin Y. Kim, Arohumam Kan, Runying Yang, Harley T. Kurata 630-P os B oard B410 THE IMPACT OF CHOLESTEROL ON GIRK CHANNELS DEPENDS ON A TRANSMEMBRANE REGION OF THE CHANNELS. Avia Rosenhouse-Dantsker 631-P os B oard B411 THE SIGNIFICANCE AND MECHANISMS OF CLUSTERING BY SLC4 COTRANSPORTERS IN THE PLASMA MEMBRANE. Harry Gill 632-P os B oard B412 THE ROLE OF ROS IN TETHERING CFTR WITHIN CERAMIDE PLATFORMS AT THE PLASMA MEMBRANE. Asmahan AbuArish , Paul W. Wiseman, John W. Hanrahan 633-P os B oard B413 REFINEMENT AND EVALUATION OF A CFTR HOMOLOGY MODEL AND IDENTIFICATION OF RESIDUES CONTROLLING CHANNEL GATING. Gorman Stock, Guiying Cui, Nael A. McCarty, James C. Gumbart 634-P os B oard B414 SOLUTION NMR TO INVESTIGATE GATING IN THE NAK CHANNEL. Joshua Brettmann , Andrew Meiburg, Katherine Henzler- B oard B415 A NEW CLASS OF POSITIVE GATING MODULATORS OF HKV3.2 CHANNELS: INSIGHTS INTO THE MECHANISM OF ACTION. Qiansheng Liang , Giuseppe Alvaro, Charles Large, Manuel Covarrubias Feng Qin 628-P os Wildman 635-P os

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland