Biophysical Society 59th Annual Meeting Program Guide

636-P os B oard B416 PKA REDUCES THE RAT AND HUMAN K CA 3.1 CURRENT, CAM BINDING AND CA 2+ SIGNALING, WHICH REQUIRES SER332/334 IN THE CAM-BINDING C TERMINUS. Raymond Wong , Lyanne C. Schlichter 637-P os B oard B417 CARDIAC SODIUM CHANNEL: ACTIVATION BY CAM INVOLVES A NAV1.5-NAV1.5 INTERACTION. Sandra B. Gabelli, Agedi Boto, Victoria Halpernin, Mario A. Bianchet, Federica Farinelli, Srinivas Aripirala, Jesse B. Yoder , Jean Jakoncic, Gordon F. Tomaselli, Mario Amzel 638-P os B oard B418 CALMODULATION OF VOLTAGE-GATED CALCIUM CHANNELS BY BLUE LIGHT. Jacqueline Niu , Manu Ben-Johny, Paul J. Adams, David T. Yue 639-P os B oard B419 PEGYLATED CHOLESTEROL AND METHYL-BETA- CYCLODEXTRIN ARE MODULATORS OF L-TYPE CALCIUM CHANNEL CURRENT AND DECREASE MEMBRANE CAPACITANCE IN VASCULAR SMOOTH MUSCLE CELLS. Rikuo Ochi , Sachin A. Gupte 640-P os B oard B420 NMDA RECEPTOR INHIBITION OF L-TYPE CALCIUM CHANNELS VIA ER CALCIUM DEPLETION AND ACTIVATION OF STIM1 IN CULTURED HIPPOCAMPAL NEURONS. Philip J. Dittmer , Mark L. Dell’Acqua, William A. Sather 641-P os B oard B421 DEFINING POST AS A MODULATOR OF STIM1 FUNCTION DURING T CELL ACTIVATION. Christina Go , Robert Hooper, Joseph Kedra, Jonathan Soboloff 642-P os B oard B422 education travel awardee THE SIGMA1 RECEPTOR COMPETES WITH STIM1 TO BIND ORAI1 TO REGULATE STORE OPERATED CALCIUM ENTRY (SOCE). Shyam Srivats , Dilshan Balasuriya, Mathias Pasche, Robert Vistal, Colin W. Taylor, Mike J. Edwardson, Ruth D. Murrell-Lagnado 643-P os B oard B423 FUNCTIONAL INTERACTION OF AN ORAI1 PORE RESIDUE WITH THE INACTIVATION DOMAIN OF STIM1. Franklin M. Mullins , Richard S. Lewis 644-P os B oard B424 STIM1 BINDING TO BOTH THE N’ AND C’ TERMINI OF ORAI1 IS CRITICAL FOR GATING OF CRAC CHANNELS. Raz Palty , Cherise Stanley, Ehud Isacoff 645-P os B oard B425 CLUSTERING OF INWARD RECTIFIER POTASSIUM CHANNELS IN A PIP2-CONTAINING MEMBRANE: A MOLECULAR DYNAMICS SIMULATION STUDY. Anna L. Duncan , Heidi Koldsø, Mark S. P. Sansom 646-P os B oard B426 DIRECT CONTACTS OF K + IONS IN THE SELECTIVITY FILTER ENABLE THE HIGH CONDUCTANCE OF K + CHANNELS. Chen Song , David A. Köpfer, Tim Gruene, George M. Sheldrick, Mark S. P. Sansom, Ulrich Zachariae, Bert L. de Groot 647-P os B oard B427 cpow travel awardee EVOLUTIONARY DIVERSITY OF PROTEIN NANODOMAINS WITHIN MAMMALIAN SPERM. Melissa R. Miller , Sam J. Kenny, Steven A. Mansell, Ke Xu, Polina Lishko

Cardiac Muscle Regulation I (Boards B428-B443)

648-P os B oard B428 A FRET-BASED ASSAY FOR MONITORING ACTIONS OF CALCIUM SENSITIZERS ON THE THIN FILAMENT. Maria E. Moutsoglou , Gi-Ho Kim, Christopher Solis-Ocampo, John M. B oard B429 SPFRET REVEALS THE MECHANISM OF MYOSIN-DEPENDENT ACTIVATION OF TROPONIN WITHIN REGULATED ACTION FILAMENTS. Gi-Ho Kim , Maria E. Moutsoglou, Christopher Solis Ocampo, John M. Robinson 650-P os B oard B430 BRIDGING INTEGRATOR 1 (BIN1) INITIATES T-TUBULE GROWTH DURING CARDIAC DEVELOPMENT AND DISEASE. David B. Lipsett , Michael Frisk, Neha Singh, Jan Magnus Aronsen, William Marszalec, Ole M. Sejersted, Ivar Sjaastad, J. Andrew Wasserstrom, Geir Christensen, William E. Louch 651-P os B oard B431 CHARACTERIZING PROTEIN BINDING OF PHOSPHOLAMBAN Robinson 649-P os TOAC SPIN LABEL CONFORMATION RESOLVED BY MD SIMULATION OF MEMBRANE-BOUND PHOSPHOLAMBAN. Andrew Reid , Jesse McCaffrey, Christine Karim, Bengt Svensson 653-P os B oard B433 USING MOLECULAR DYNAMICS SIMULATIONS TO INTERPRET FLUORESCENCE AND EPR DATA ON LABELED SERCA AND PHOSPHOLAMBAN. Bengt Svensson , Xiaoqiong Dong, Karl J. Petersen, Zachary M. James, Jesse E. McCaffrey, Howard S. Young, David D. Thomas 654-P os B oard B434 PHOSPHOLAMBAN PHOSPHORYLATION ALTERS ITS CONFORMATIONAL EQUILIBRIUM TO REGULATE SERCA ACTIVITY. Leanna McDonald , Gianluigi Veglia 655-P os B oard B435 ATOMIC-LEVEL CHARACTERIZATION OF THE INHIBITION MECHANISM OF THE CALCIUM PUMP BY PHOSPHOLAMBAN. L. Michel Espinoza-Fonseca , Joseph M. Autry, G. Lizbeth Ramírez-Salinas, David D. Thomas 656-P os B oard B436 NOVEL ROLES OF GQ-DEPENDENT SIGNAL TRANSDUCTION FOR CARDIAC PACEMAKING AND CARDIAC IMPULSE PROPAGATION STUDIED BY GQ-KO AND A DREADD. Elisabeth Kaiser, Laura Schröder, Kathrina Wiesen, Jürgen Wess, Qinghai Tian, Lars Kaestner, Peter Lipp 657-P os B oard B437 THE LARGE SCALE TRANSCRIPTOME ANALYSIS OF MOUSE SINOATRIAL NODE (SAN). Yosuke Okamoto , Kirill V. Tarasov, Bruce D. Ziman, Joonho Lee, Edward G. Lakatta 658-P os B oard B438 A SIMPLE REGULATION OF CARDIOMYOCYTE EXCITABILITY. Karni S. Moshal TO SERCA USING CHEMICAL CROSS-LINKING. Vidhya Sivakumaran , Nikolai Smolin, Seth Robia 652-P os B oard B432

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland