Biophysical Society 59th Annual Meeting Program Guide

950-S ymp 11:15 am THE MITOCHONDRIAL CALCIUM UNIPORTER: MOLECULAR COMPOSITION AND PHYSIOLOGICAL ROLE. Rosario Rizzuto 951-S ymp 11:45 am MOLECULAR MECHANISMS OF MITOCHONDRIAL CA 2+ UPTAKE: ROLE OF MICU1 AND ITS PARALOGS. György Hajnóczky 952-S ymp 12:15 pm HIGH-AFFINITY INTERACTION WITH VDAC LINKS CYTOSOLIC PROTEINS TO MITOCHONDRIAL REGULATION IN HEALTH, CANCER, AND NEURODEGENERATION. Tatiana K. Rostovtseva , Philip A. Gurnev, David P. Hoogerheide, Eduardo N. Maldonado, John J. Lemasters, Olga Protchenko, Jennifer C. Lee, Sergey M. Bezrukov 10:45 am –12:45 pm , B allroom IV Platform Electron Microscopy and Solution Scattering Co-Chairs Doreen Matthies, NIH Daisbube Kihare, Purdue University 953-P lat 10:45 am GFP FOR EM: SITE-SPECIFIC LABELING OF PROTEINS FOR ELECTRON MICROSCOPY. Corey M. Dambacher , Gabriel C. Lander 954-P lat 11:00 am FAST SHAPE-BASED GLOBAL AND LOCAL ELECTRON DENSITY MAP SEARCH. Juan Esquivel-Rodriguez, Xusi Han, Charles Christoffer, Xuejiao Kang, Lyman Monroe, Daisuke Kihara 955-P lat 11:15 am CYCLOPHILIN A STABILIZES THE MATURE HIV-1 CAPSID THROUGH A NOVEL NON-CANONICAL BINDING SITE. Peijun Zhang , Chuang Liu, Juan R. Perilla, In-Ja Byeon, Jiying Ning, Jinwoo Ahn, Chris Aiken, Angela M. Gronenborn, Tatyana Polenova, Klaus Schulten 956-P lat 11:30 am RESIDUE SPECIFIC RADIATION DAMAGE OF PROTEIN STRUCTURES USING HIGH-RESOLUTION CRYO-ELECTRON MICROSCOPY. Doreen Matthies , Alberto Bartesaghi, Alan Merk, Soojay Banerjee, Sriram Subramaniam 957-P lat 11:45 am 3D ULTRASTRUCTURAL INVESTIGATION OF ENTIRE PANCREATIC ISLETS OF LANGERHANS BY SERIAL BLOCK FACE SCANNING ELECTRON MICROSCOPY. Gina N. Calco, Jake D. Hoyne, Bryan C. Kuo , Maria A. Aronova, Guofeng Zhang, Andre Shomorony, Charlotte R. Pfeifer, Tao Cai, Huanyu Xu, Abner L. Notkins, Richard D. Leapman 958-P lat 12:00 pm SUPERRESOLUTION FLUORESCENCE MICROSCOPY WITHIN A SCANNING ELECTRON MICROSCOPE. Craig L. Hetherington , Connor G. Bischak, Claire E. Stachelrodt, Jake T. Precht, Zhe Wang, Darrell G. Schlom, Naomi S. Ginsberg 959-P lat 12:15 pm CCP-SAS - NOVEL APPROACHES FOR THE ATOMISTIC MODELLING OF SMALL ANGLE SCATTERING DATA IN BIOLOGY. David W. Wright , Ruodan Nan, Gar-Kay Hui, Joseph E. Curtis, Emre H. Brookes, Stephen J. Perkins

10:45 am –12:45 pm , B allroom I Symposium Epigenetics

Chair Lene Oddershede, University of Copenhagen, Denmark 941-S ymp 10:45 am COST AND PRECISION IN SMALL GENE REGULATORY NETWORKS. Aleksandra Walczak 942-S ymp 11:15 am METAPHASE CHROMATIN PLATES EXPLAIN THE STRUCTURE AND PHYSICAL PROPERTIES OF CONDENSED CHROMOSOMES. Joan-Ramon Daban 943-S ymp 11:45 am COOPERATIVITY AND SUPERCOILING MODULATE FUNCTIONS OF HUMAN O6-ALKYLGUANINE DNA ALKYLTRANSFERASE. Michael G. Fried , Manana Melikishvili, Ingrid Tessmer 944-S ymp 12:15 pm DNA SUPERCOILING ENHANCES COOPERATIVITY AND EFFICIENCY OF AN EPIGENETIC SWITCH. Kamilla Nørregaard, Magnus Andersson, Peter E. Nielsen, Stanley Brown, Lene B. Oddershede 10:45 am –12:45 pm , B allroom II Symposium Mechanisms of Actin Filament Nucleation and Mechanotransduction Chair Roberto Dominguez, University of Pennsylvania 945-S ymp 10:45 am MECHANOSENSITIVITY OF FORMIN-ACTIN INTERACTIONS. Guillaume Romet-Lemonne 946-S ymp 11:15 am WISH/DIP/SPIN90 PROTEINS ACTIVATE ARP2/3 COMPLEX TO CREATE LINEAR ACTIN FILAMENTS THAT SEED ASSEMBLY OF BRANCHED ACTIN NETWORKS. Brad Nolen 947-S ymp 11:45 am TWO TYPES OF ACTIN NUCLEATORS, THREE WAYS TO MAKE ACTIN FILAMENTS? Margot Quinlan 948-S ymp 12:15 pm MOLECULAR MECHANISM OF ACTIN FILAMENT NUCLEATION BY LEIOMODIN (LMOD). Malgorzata Boczkowska, Grzegorz Rebowski, Roberto Dominguez 10:45 am –12:45 pm , B allroom III Symposium Molecular Basis for Mitochondrial Signaling Chair Tatiana Rostovtseva, NIH 949-S ymp 10:45 am SYSTEMS APPROACHES TO MITOCHONDRIAL CALCIUM SIGNALING. Jennifer Wettmarshausen, Yiming Cheng, Fabiana Perocchi

66

Biophysical Society 59 th Annual Meeting, Baltimore, Maryland