Biophysical Society 59th Annual Meeting Program Guide

960-P lat 12:30 pm INTERPRETATION OF SOLUTION X-RAY SCATTERING DATA BY MOLECULAR DYNAMICS. Po-chia Chen, Levin Brinkmann, Jochen S. Hub

970-P lat 11:00 am COMBINATIONAL EVIDENCE THAT INTRINSIC DISORDER PROVIDES BROAD ASSOCIATION PROFILES. Travis A. Hoppe , 11:15 am THE INTRINSICALLY DISORDERED C. TRACHOMATIS TARP BINDS ACTIN WITH A PARTIALLY PREFORMED HELIX. James L. Tolchard, Ted Hackstadt, Tharin M. A. Blumenschein 972-P lat 11:30 am POST-TRANSLATIONAL MODIFICATION OF P27 REGULATES SIGNAL TRANSMISSION VIA A DYNAMIC INTERACTION WITH CDK2/CYCLIN. Hugo Sanabria , Maksym Tsytlonok, Yuefeng Wang, Cheon-Gil Park, Suren Felekyan, Katherina Hemmen, Peter Tompa, Claus A. M. Seidel 973-P lat 11:45 am EFFECTS OF CHARGE INTERACTIONS AND TRANSIENT SECONDARY STRUCTURE ELEMENTS ON THE FUNCTION OF THE DISORDERED RAM REGION OF THE NOTCH RECEPTOR. Kathryn Sherry , Rahul Das, Rohit Pappu, Doug Barrick 974-P lat 12:00 pm MOLECULAR SIMULATIONS OF UNFOLDED AND INTRINSICALLY DISORDERED PROTEINS. Gül H. Zerze , Robert B. Best, Jeetain Mittal 975-P lat 12:15 pm CONFORMATIONAL ENTROPIES OF UNFOLDED PEPTIDES: THE SOURCE OF A REALISTIC ESTIMATION OF THE ENTROPY OF UNFOLDED PEPTIDES AND PROTEINS. Reinhard Schweitzer-Stenner , Siobhan E. Toal 976-P lat 12:30 pm EVIDENCE FOR INTERNAL FRICTION IN IDPS OF THE CALCITONIN PEPTIDE FAMILY. Sara M. Sizemore, Stephanie M. Cope, Sara M. Vaiana 10:45 am –12:45 pm , R oom 314/315 Platform Cardiac, Smooth, and Skeletal Muscle Electrophysiology Co-Chairs Cathy Proenza, University of Colorado, Denver Eleonora Grandi, University of California, Davis 977-P lat 10:45 am IONIC MECHANISMS THAT UNDERLIE VENTRICULAR ACTION POTENTIAL PROLONGATION FOLLOWING LOSS OF CAVEOLIN-3 IN ADULT TRANSGENIC MICE. Vignesh Ramchandran , Thomas O’Hara, Yogananda S. Markandeya, Ravi C. Balijepalli, Timothy J. Kamp, Natalia A. Trayanova 978-P lat 11:00 am DIABETES SLOWS HEART RATE VIA ELECTRICAL REMODELING OF K + CURRENTS IN SINOATRIAL NODE MYOCYTES. Joshua R. St. Clair, Emily J. Sharpe, Andrew Hagar, Clayton Garthe, Julie Juchno, Cathy Proenza 979-P lat 11:15 am CARDIAC SPECIFIC LEUCINE-RICH REPEAT CONTAINING 10 (LRRC10) PROTEIN INTERACTS WITH AND REGULATES THE CAV1.2 L-TYPE CA2+ CHANNELS. Marites T. Woon , Adrian C. Grimes, Courtney R. Reynolds, Matthew J. Brody, Youngsook Lee, Ravi C. Balijepalli Robert Best 971-P lat

M O N D A Y

10:45 am –12:45 pm , R oom 307/308 Platform Ligand-gated Channels

Co-Chairs John Baenziger, University of Ottawa, Canada Cynthia Czajkowski, University of Wisconsin-Madison 961-P lat 10:45 am

DIVERGENT ROLES FOR M4 IN THE GATING OF TWO PROKARYOTIC PENTAMERIC LIGAND-GATED ION CHANNELS. Camille M. Henault, Peter F. Juranka, Julian S. Surujballi, John E. Baenziger 962-P lat 11:00 am SINGLE MOLECULE MOTION MAP OF GLIC BY DIFFRACTED X-RAY TRACKING. Hiroshi Sekiguchi , Yufuku Matsushita, Yuri Nishino, Keigo Ikezaki, Atsuo Miyazawa, Naoto Yagi, Christele Huron, Jean-Pierre Changeux, Pierre-Jean Corringer, Yuji C. Sasaki 963-P lat 11:15 am education travel awardee AN ELIC-GLIC CHIMERA REVEALS DISTINCT PATHWAYS OF ACTIVATION IN THE CYS-LOOP FAMILY OF RECEPTORS. Nicolaus Schmandt , David T. Lodowski, Vivien Yee, Sudha Chakrapani 964-P lat 11:30 am education travel awardee DISULFIDE TRAPPING THE GABA-A RECEPTOR EXTRACELLULAR BETA-5/BETA-5’ LOOP. Cassandra M. Theusch , Cynthia Czajkowski 965-P lat 11:45 am CONFORMATIONAL DYNAMICS IN THE GABAA RECEPTOR. Rilei Yu, Philip C. Biggin 966-P lat 12:00 pm MONITORING THE WORK OF A SINGLE SUBUNIT IN HOMOTETRAMERIC CNGA2 CHANNELS. Klaus Benndorf , Nisa Wongsamitkul, Vasilica Nache, Thomas Eick, Sabine Hummert, Eckhard Schulz, Ralf Schmauder, Jana Schirmeyer, Thomas Zimmer 967-P lat 12:15 pm ALLOSTERIC REGULATION OF THE CYCLIC NUCLEOTIDE- BINDING DOMAIN IN HCN CHANNELS. Hannah A. DeBerg , Shahidul M. Islam, Michael C. Puljung, Benoit Roux, William N. Zagotta, Stefan Stoll 968-P lat 12:30 pm RAPID ACTIVATION OF DISTINCT CONDUCTING STATES IN P2X RECEPTOR CHANNELS. Mufeng Li , Gilman Toombes, Shai D. Silberberg, Kenton J. Swartz 10:45 am –12:45 pm , R oom 309/310 Platform Intrinsically Disordered Proteins (IDP) Co-Chairs Tharin Blumenschein, University of East Anglia, United Kingdom Travis Hoppe, Drexel University 969-P lat 10:45 am A NEW AND UN-CONVENTIONAL ULTRAFAST BINDING MECHANISM OF INTRINSICALLY DISORDERED PROTEINS TO STRUCTURED PARTNERS. Davide Mercadante , Sigrid Milles, Edward A. Lemke, Frauke Gräter

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland