Biophysical Society 59th Annual Meeting Program Guide

980-P lat 11:30 am THE CA 2+ CLOCK IS NOT GOVERNED BY A SINGLE CAMKII OR PKA PHOSPHORYLATION SITE FOR FIGHT OR FLIGHT RESPONSES. Yuejin Wu , William J. Kutschke, Hector H. Valdivia, Xander H.T. Wehrens, Mark E. Anderson 981-P lat 11:45 am RANOLAZINE PREVENTS PHASE-3 EARLY AFTERDEPOLARIZATIONS IN HUMAN ATRIAL MYOCYTES BY INHIBITING NA CURRENT NON-EQUILIBRIUM REACTIVATION. Stefano Morotti, Andrew D. McCulloch, Donald M. Bers, Andrew G. Edwards, Eleonora Grandi 982-P lat 12:00 pm PROBING THE TRAFFICKING ROUTES OF KCNQ1 AND KCNE1 AFTER THEIR ER EXIT. Min Jiang, Mei Zhang, Scott C. Henderson, Tseng Gea-Ny 983-P lat 12:15 pm TRAFFICKING AND GATING MECHANISMS OF HERG1A C-TERMINUS (LQTS-2) TRUNCATION MUTATIONS ON HERG1A-HERG1B HETERO-MULTIMERIC CHANNEL. Akil Puckerin, Donald D. Chang, Prakash Subramanyam, Henry M. Colecraft, Ademuyiwa S. Aromolaran 984-P lat 12:30 pm DOMINANT NEGATIVE CONSEQUENCES OF A HERG 1B MUTATION ASSOCIATED WITH INTRAUTERINE FETAL DEATH. David K. Jones , Sunita Joshi, Fang Liu, Gail A. Robertson 10:45 am ON THE NA + /H + SELECTIVITY OF MEMBRANE TRANSPORTERS AND ENZYMES: EXPERIMENTAL AND THEORETICAL STUDIES OF AN ATP-SYNTHASE ROTOR RING. Vanessa Leone , Ernst Grell, Denys Pogoryelov, Thomas Meier, José D. Faraldo-Gómez 986-P lat 11:00 am education travel awardee RECENT STRUCTURES AND MOLECULAR DYNAMICS SIMULATIONS OFFER NEW PERSPECTIVE ON NA + /H + ANTIPORTERS. David L. Dotson , Chiara Lee, Shoko Yashiro, Povilas Uzdavinys, Christoph von Ballmoos, David Drew, Alexander D. Cameron, Oliver Beckstein 987-P lat 11:15 am education travel awardee UNDERSTANDING SELECTIVITY OF THE NA + /K + -ATPASE USING A COMPUTATIONAL APPROACH. Asghar M. Razavi , Vincenzo Carnevale, Lucie Delemotte, Vincent A. Voelz 988-P lat 11:30 am X-RAY CRYSTALLOGRAPHIC STUDY OF NA,K-ATPASE IN COMPLEX WITH CARDIOTONIC STEROIDS. Haruo Ogawa , Kanna Motoyama, Flemming Cornelius, Bente Vilsen, Chikashi 10:45 am –12:45 pm , R oom 316/317 Platform Membrane Pumps, Transporters, and Exchangers II Co-Chairs Vanessa Leone, NIH Eduardo Chufan, NIH 985-P lat

P-GLYCOPROTEIN RESPONSIBLE FOR THE DRUG-MEDIATED INHIBITION OF ATP HYDROLYSIS. Eduardo E. Chufan , Khyati Kapoor, Suresh V. Ambudkar 990-P lat 12:00 pm education travel awardee THE HYDROLYSIS CYCLE OF ATP-BINDING CASSETTE NUCLEOTIDE-BINDING DOMAINS. Srinivasan Krishnan , Maria E. Zoghbi, Guillermo A. Altenberg 991-P lat 12:15 pm RECONSTITUTION OF HUMAN ABC TRANSPORTER MRP3 INTO GIANT UNILAMELLAR VESICLES FOR SINGLE MOLECULE TRANSPORT RECORDINGS ON MICRO- STRUCTURED BIOCHIPS. Patrick Seelheim , Adriane Wüllner, Hans- Joachim Galla 992-P lat 12:30 pm MOLECULAR DYNAMICS SIMULATION STUDY OF A MUTANT CONSTRUCT OF THE ARCHAEAL GLUTAMATE TRANSPORTER GLTPH WITH TRANSPORT RATES AS FAST AS ITS HUMAN COUNTERPART. Michel A. Cuendet , Sebastian Stolzenberg, George Khelashvili, Harel Weinstein 11:30 am –12:30 pm , R oom 301/302/303 Career Center Workshop Career Planning and Job Searching for Learn how to create a flexible career plan for yourself, and identify and leverage your skills, expertise and experience to find a career (not just a job) that is right for you. Special emphasis will be placed on tips for finding and launching a career in academia, but we will also incorporate the development of a contingency plan for the unexpected twists and turns in life. 11:30 am –1:00 pm , H all C, R oom A Exhibitor Presentation Asylum Research, an Oxford Instruments Company There’s No Other AFM Like Cypher™ – High Resolution Atomic Force Microscopy Made Easier and Faster Asylum Research has focused on improving AFM instrumentation to make imaging in liquid easier, faster and more quantitative for life science applications. Please join us for this ‘Lunch and Learn’ presentation that will focus on the latest technical advances in AFM that enable high resolution imaging of the structure and dynamics of samples including proteins, lipids and nucleic acids. We’ll show examples of how the Cypher ES Environmental AFM allows users to control the environment around their sample and perform perfusion experiments easily. You’ll learn about Cypher’s numerous ease-of-use features such as GetStarted™, GetReal™, and blueDrive™ for easy and stable imaging in liquid. We will introduce you to Fast Force Mapping, our unique technology that measures mechanical properties of your samples faster and more reliably. This is also a great opportunity to ask our scientists any questions you may have about AFM. Presenter Irène Revenko, Applications Scientist, Asylum Research, an Oxford Instruments Company Science Professionals: Academic Opportunities

Toyoshima 989-P lat

11:45 am IDENTIFICATION OF STRUCTURAL MOTIFS IN

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland