Biophysical Society 59th Annual Meeting Program Guide

11:45 am –1:15 pm , R oom 327/328/329 Undergraduate Student Pizza “Breakfast” The Education Committee is hosting this “breakfast” for undergraduate students. This session provides a valuable networking and social opportunity for undergraduate student attendees to meet other students and Committee members, to discuss academic goals and questions, and to develop a biophysics career path. The Emily M. Gray Awardee will also give a talk at this event. Limited to the first 100 attendees. Emily Gray Awardee Speaker Meyer Jackson, University of Wisconsin-Madison 12:30 pm –2:00 pm , H all C, R oom B Exhibitor Presentation Nanion Technologies GmbH HTS-Compatible Giga-Seal Ion Channel Drug Discovery: Beyond the Bottleneck and Ready for CiPA Nanion Technologies is one of the leading providers of automated patch clamp systems, offering a diverse product portfolio covering a broad experimental range from single channel recordings to HTS-compatible ion channel screening from up to 768 cells in parallel. Allowing 20,000 data points per day, the SyncroPatch 384/768PE is unrivalled for high throughput and high quality recordings. Diverse ion channel targets and cell types have successfully been tested on the SyncroPatch 384/768PE including challenging targets such as fast desensitizing ligand ion channels (P2X3 und GluA2), ion channels requiring intracellular activation (Katp, TMEM16a) and heavily regulated channels such as TRPA1. Early cardiac arrhythmic risk assessment is a hot topic these days calling for new safety screening strategies. Patchliner, a medium-throughput APC platform, supports automated current clamp recordings, experiments at physiological temperatures, and a minimal cell usage, making it the ideal partner for safety testing on stem cell derived cardiomyocytes. Additionally, the CardioExcyte 96, a unique hybrid system for parallel impedance-based and MEA-like recordings from intact cardiomyocyte networks, has proven a versatile tool for safety and toxicity screening applications serving as an excellent complement to APC. These three platforms enable you to keep up with the requirements of the CiPA- initiative for early prediction of potential cardiac arrhythmias. During this workshop, we will show how to push the boundaries of ion channel screening projects to achieve HTS-screening standards, and how to get ready for comprehensive safety screening beyond hERG. Spaces are limited so reserve yours by sending an email to info@nanion.de. Presenters Niels Fertig, CEO, Nanion Technologies Andrea Brüggemann, CSO, Nanion Technologies 1:00 pm –3:00 pm , H all C Graduate and Postdoc Institution Fair This fair will introduce students and postdoctoral candidates to colleges and universities with leading programs in biophysics. Registration is not needed to participate.

1:00 pm –3:00 pm , R oom 324/325 Grant Writing Workshop

How (Not) to Write Your NIH Grant Proposal Through mock study sections and discussions, veteran NIH officials will demonstrate what review panels look for when they read and assess proposals. They will also answer questions about peer review, avoiding application pitfalls and responding to review concerns. This session is sponsored by the Public Affairs Committee and is appropriate for both experienced principal investigators and those applying for their first grant. Speakers Jean Chin, NIGMS, NIH Catherine Lewis, NIGMS, NIH James Mack, CSR, NIH Don Schneider, CSR, NIH Mary Ann Wu, NIGMS, NIH 1:30 pm –3:00 pm , H all C, R oom A Exhibitor Presentation World Precision Instruments Side-Stepping the Animal Model: Cardiac Work Loops in Human iPSC-derived Myocytes Cardiac pressure-volume loops on a complete organ provide the framework for understanding cardiac mechanics in experimental animal models, most notably in the context of Frank-Starling mechanisms. With the development of more sensitive transducers, this work has been applied to single cardiac cells, using freshly isolated cells from an animal model. With the advent of iPSC-derived myocytes, a whole new range of cell types is now available to the investigator. We introduce a novel mounting application for overcoming the technical difficulties in instrumenting these cells for force measurements. With this technology, it is now possible to conduct experiments on human stem cell-derived myocytes. We will show preliminary results, the tools required for these types of experiments, mounting methods, and a novel method for direct force measurements on human iPSC-derived myocytes. In addition, two different methods for real-time determination of length changes in isolated iPSC-derived myocytes will be presented. The results are preliminary, however indicate the possibility for not only a reduction in the use of the animal models in cardiac research, but also the direct investigation of human cardiovascular disease. 1:30 pm –3:00 pm , R oom 330 Biophysics 101: Super-Resolution Microscopy Eric Betzig, Stefan W. Hell and William E. Moerner were awarded the Nobel Prize in Chemistry 2014 for their great achievements in developing super-resolution/single-molecule microscopy. This revolutionary progress in optical microscopy enables us to have an unprecedented power peering into the nanoworld in live organisms. This year’s “Biophysics 101” session will include two lectures on this topic, outlining the practice of super- resolution/single-molecule microscopy for not-yet-experts, and describing some of its uses and rewards. The session is part of a continuing series of symposia initiated by the Education Committee to educate the Society membership about fundamentals of various biophysical techniques with which they may not be familiar but might want to use. Speakers Keith Lidke, University of New Mexico Weidong Yang, Temple University

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Biophysical Society 59 th Annual Meeting, Baltimore, Maryland