Biophysical Society 60th Annual Meeting

1365-Pos Board B342 A NON-CANONICAL VOLTAGE SENSOR CONTROLS GATING IN K2P K + CHANNELS. Marcus Schewe , Ehsan Nematian-Ardestani, Han Sun, Marianne Musinszki, Sönke Cordeiro, Giovanna Bucci, Bert L. de Groot, Stephen J. Tucker, Markus Rapedius, Thomas Baukrowitz 1366-Pos Board B343 VARIABLE ELECTROSTATIC REPULSION MODEL OF ION-CHANNEL ACTIVA- TION VS. GATED PORE WITH “NEUTRALIZED” S4 SEGMENTS. H. Richard Board B344 IDENTIFICATION OF RESIDUES IMPORTANT FOR THE PUFA SENSITIVITY OF IKS.  Johan E. Larsson , H Peter Larsson, Sara I. Liin 1368-Pos Board B345 RELAXATION OF THE VOLTAGE SENSING MODULES OF EXCITATION- CONTRACTION (EC) COUPLING IN MAMMALIAN SKELETAL MUSCLE.  Juan Ferreira , German Pequera, Carlo Manno, Eduardo Rios, Gustavo Brum 1369-Pos Board B346 EFFECT OF 2-AMINOETHYLMETHANETHIOSULPHONATE (MTSEA) ON THE HKV1.3_L346C AND THE HKV1.3_L346C_L418C MUTANT CHAN- NELS. Ann-Kathrin Diesch , Stephan Grissmer 1370-Pos Board B347 EDUCATION TRAVEL AWARDEE ELUCIDATION OF MOLECULAR MECHANISM UNDERLYING KCSA’S HYS- TERETIC GATING BEHAVIOR. Cholpon Tilegenova , D. Marien Cortes, Luis Board B348 GINSENOSIDE RG3 ACTIVATES HUMAN EAG FAMILY OF K + CHANNELS VIA ALLOSTERIC MODIFICATION OF GATING. Wei Wu , Alison Gardner, Michael Sanguinetti 1372-Pos Board B349 HERG S4-S5 ACTS AS A VOLTAGE-DEPENDENT LIGAND BINDING THE AC- TIVATION GATE AND LOCKING IT IN A CLOSED STATE. Olfat Malak , Gildas Loussouarn, Zeineb Es-Salah-Lamoureux 1373-Pos Board B350 7-DEHYDROCHOLESTEROL MODIFIES THE OPERATION OF KV1.3 CHAN- NELS IN T CELLS ISOLATED FROM SMITH-LEMLI-OPITZ SYNDROME PATIENTS. Andras Balajthy , Zoltan Petho, Sandor Somodi, Zoltan Varga, Maria Peter, Laszlo Vígh, Gabriella P. Szabó, Gyorgy Paragh, Gyorgy Panyi, Peter Hajdu 1374-Pos Board B351 KV 7.4 CHANNEL ACTIVITY IS DEPENDENT UPON PIP2 AND Gβγ SUB- UNITS. Oleksandr Povstyan , Jennifer Stott, Vincenzo Barrese, Iain Greenwood 1375-Pos Board B352 MOUSE CARDIAC MITOBK CA ASSOCIATES WITH β1 SUBUNIT FAVORING CHANNEL EXPRESSION AND ACTIVITY. Enrique Balderas Angeles , Ric- cardo Olcese, Ligia Toro, Enrico Stefani 1376-Pos Board B353 BK CHANNEL SUBPROTEOME INCLUDES NOVEL MITOCHONDRIAL PART- NERS: ADP/ATP CARRIER AND TOM 22 IMPORT RECEPTOR.  Jin Zhang , Zhu Zhang, Ronghui Zhu, Min Li, Rong Lu, Yong Wu, Riccardo Olcese, Enrico Stefani, Ligia Toro 1377-Pos Board B354 DIFFERENTIAL EXPRESSION OF BK CHANNEL ALPHA AND BETA1 SUB- UNITS IN RAT CEREBRAL ARTERIES. Guruprasad Kuntamallappanavar , Shivantika Bisen, Anna N. Bukiya, Alex M. Dopico 1378-Pos Board B355 BK AND CAV1.3 CHANNELS ORGANIZE IN CLUSTERS THAT CONTROL EX- CITABILITY IN NEURONS. Oscar Vivas , Claudia M. Moreno, Luis F. Santana, Bertil Hille Leuchtag 1367-Pos G. Cuello 1371-Pos

1379-Pos Board B356 FUNCTIONAL IMPACT OF P320 IN HSLO1 BK CHANNEL GATING. Guido Gessner , Toshinori Hoshi, Stefan H. Heinemann 1380-Pos Board B357 BK CHANNEL C-LINKER AND AC REGION ARE CRUCIAL FOR AUXILIARY β2 SUBUNIT REGULATIONS. Zhenzhen Yan, Bin Hu, Xiying Guo, Anxi Weng, Ling Zhong, Feng Xiao, Jiuping Ding, Panpan Hou 1381-Pos Board B358 EFFECTS OF SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) ON BK K + CHANNEL PROPERTIES. Amber E. Plante , Michael H. Lai, Andrea L. Board B359 17Β-ESTRADIOL BINDS AND MODULATES BK CHANNEL THROUGH ITS Β1 AUXILIARY SUBUNIT. Sara T. Granados , Felipe Bravo, Romina Sepúlveda, Danilo González-Nilo, Janneth Gonzalez, Ramón Latorre, Yolima Torres 1383-Pos Board B360 REGULATION OF KV11.1 C-TERMINAL ISOFORM EXPRESSION BY HU PRO- TEINS. Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou 1384-Pos Board B361 CALCIUMMODULATES HERG FUNCTION BY ACTING AT TWO DISTINCT BINDING SITES. Davindeep Brar, Seth Ching, Kristoffer Chin, Andrew Nguyen, Alan Miller 1385-Pos Board B362 ENERGETIC CONTRIBUTIONS OF AROMATIC RESIDUES IN HV1 BLOCK BY 2-GUANIDINOIMIDAZOLES AND IN HV1 VOLTAGE-DEPENDENT ACTIVA- TION. Liang Hong , Jason D. Galpin, Christopher A. Ahern, Francesco Tombola 1386-Pos Board B363 EXPLORATION OF THE LAST, CHANNEL OPENING TRANSITION OF THE VOLTAGE SENSOR S4 IN A POTASSIUM CHANNEL.  Jakob Renhorn , Luca Conti, Fredrik Elinder 1387-Pos Board B364 LIPOSOME-BASED IN VITRO BIOSYNTHESIS OF TWO-PORE DOMAIN PO- TASSIUM CHANNELS FOR FUNCTIONAL STUDIES. Marianne A. Musinszki , Thomas Baukrowitz 1388-Pos Board B365 A CHARGED RESIDUE IN THE HCN CHANNEL C-LINKER STABILIZES THE OPEN STATE. Dana A. Page , Edgar C. Young 1389-Pos Board B366 CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF CYCLIC NUCLEO- TIDE BINDING DOMAIN (CNBD) FROM HCN2 CHANNEL. Vadim A. Klenchin , Claudia P. Alvarez-Baron, John Cowgill, Qiang Cui, Baron Chanda 1390-Pos Board B367 HYDRATION OF CRITICAL RESIDUES IN THE SHAKER KV CHANNEL GOV- ERNS THE ENERGY LANDSCAPE AND TEMPERATURE DEPENDENCE OF CHANNEL GATING. Sandipan Chowdhury , Brian W. Jarecki, Baron Chanda 1391-Pos Board B368 THE ROLE OF ION BINDING SITES IN C-TYPE INACTIVATION OF A K CHAN- NEL. KimMatulef, Francis Valiyaveetil 1392-Pos Board B369 MULTI-MICROSECOND MOLECULAR DYNAMICS SIMULATIONS OF THE HV1 PROTON CHANNEL. Andrew Geragotelis , Mona L. Wood, Hendrik Goeddeke, Saleh Riahi, Scott A. Hollingsworth, J. Alfredo Freites, Francesco Tombola, Douglas J. Tobias Meredith 1382-Pos

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