Biophysical Society 60th Annual Meeting

1470-Pos Board B447 DYNAMIC TRANSIENT RESPONSES OF MUSCLE FIBERS WITH A HETERO- GENEOUS POPULATIONS OF ISOFORMS AND MUTATION. Srboljub M. Mijailovich, Djordje Nedic, Marina Svicevic, Boban Stojanovic, Michael Regnier, Michael A. Geeves 1471-Pos Board B448 DIRECT MEASUREMENTS OF LOCAL COUPLING BETWEEN MYOSIN MOL- ECULES ARE CONSISTENT WITH A MODEL OF MUSCLE ACTIVATION. Sam Walcott , Neil M. Kad 1472-Pos Board B449 ASSUMING THAT MYOSIN-BINDING PROTEIN C INTERACTS WITH BOTH MYOSIN AND ACTIN CAN EXPLAIN ITS ROLE IN SKINNED FIBER MECHAN- ICS.  Jonas Schwan , Clinton Wang, Stuart G. Campbell 1473-Pos Board B450 ESSENTIAL ROLES OF WATER IN ACTIN-MYOSIN BINDING. Hiraku Oshima , Tomohiko Hayashi, Masahiro Kinoshita 1474-Pos Board B451 REGENERATION OF ACTIN FILAMENTS IN ACTIN-EXTRACTED BUMBLEBEE FLIGHT MUSCLE FIBERS AS PROBED BY X-RAY DIFFRACTION. Hiroyuki Board B452 THE STRUCTURE OF THE RELAXED THICK FILAMENTS FROM LETHOCERUS ASYNCHRONOUS FLIGHT MUSCLE. Zhongjun Hu , Dianne W. Taylor, Michael K. Reedy, Robert J. Perz-Edwards, Kenneth A. Taylor 1476-Pos Board B453 THE STRUCTURE OF THE RELAXED THICK FILAMENTS FROM LETHOCERUS ASYNCHRONOUS FLIGHT MUSCLE - IMPLICATIONS FOR STRETCH ACTIVA- TION. Kenneth A. Taylor , Zhongjun Hu, Dianne W. Taylor, Michael K. Reedy, Robert J. Perz-Edwards 1477-Pos Board B454 THE AGE ASSOCIATED ALTERATION IN ECCENTRIC CONTRACTION PROPERTIES DURING A STRETCH SHORTENING CYCLE IN FAST AND SLOW TWITCH MOUSE MUSCLES. Anthony L. Hessel , Kiisa C. Nishikawa 1478-Pos Board B455 EFFECT OF ACTIVE SHORTENING AND STRETCHING ON LATTICE SPAC- ING AND CROSS-BRIDGE BINDING IN SKINNED MUSCLE FIBRES. Venus Joumaa , Ian C. Smith, Tim R. Leonard, Olga Antipova, Thomas C. Irving, Walter Herzog 1479-Pos Board B456 MYOSIN MGADP RELEASE RATE DECREASES WITH GREATER SARCOMERE LENGTH AND REDUCED THICK-TO-THIN FILAMENT SPACING IN SKINNED SOLEUS MUSCLE FIBERS FROM RATS. Axel J. Fenwick , Shelby R. Leighton, Bertrand C.W. Tanner 1480-Pos Board B457 SARCOMERE LENGTH AND PASSIVE SARCOMERE LENGTHENING ARE LOCATION-DEPENDENT IN LIVE MOUSE TIBIALIS ANTERIOR MUSCLE. Eng Kuan Moo , Rafael Fortuna, Ziad Abusara, Walter Herzog 1481-Pos Board B458 DYNAMICS OF TRANSITIONS THROUGH THE MOLTEN-GLOBULE STATE ENHANCE CONTRACTILITY OF TITIN. Zsolt Martonfalvi , Pasquale Bianco, Gyorgy Ferenczy, Katalin Naftz, Miklos Kellermayer 1482-Pos Board B459 THE PEVK REGION OF TITIN: DECIPHERING THE MOLECULAR INTERAC- TIONS OF ELASTICITY. Sudarshi Premawardhana , Matthew J. Gage 1483-Pos Board B460 ASSESSING THE FUNCTIONAL ROLE OF TITIN N2A-PEVK REGION IN AC- TIVE MUSCLE CONTRACTION. Humra Athar , Matthew J. Gage Iwamoto 1475-Pos

1484-Pos Board B461 I-BAND TITIN INTERACTION WITH MYOSIN IN THE MUSCLE SARCOMERE DURING ECCENTRIC CONTRACTION: THE TITIN ENTANGLEMENT HYPOTH- ESIS. Mike DuVall , Azim Jinha, Gudrun Schappacher-Tilp, Tim Leonard, Walter Herzog 1485-Pos Board B462 USING SINGLE MYOSIN AND SMALL MYOSIN ENSEMBLES TO EXAMINE THIN FILAMENT ACTIVATION IN A LASER TRAP ASSAY. Thomas Longyear , Matt Unger, Ling Xin, SamWalcott, Edward P. Debold 1486-Pos Board B463 THE RELATIVE INFLUENCE OF ACTIN-MYOSIN ATTACHMENT AND DETACHMENT KINETICS ON ACTIN SLIDING VELOCITIES IS MODULATED BY MYOSIN DENSITY.  Josh E. Baker , Travis J. Stewart, Samuel P. Dugan, Christine R. Cremo 1487-Pos Board B464 THE ACIDOSIS-INDUCED SLOWING OF REGULATED THIN FILAMENT VE- LOCITY IN A MOTILITY ASSAY DISAPPEARS AT LOW ATP. Edward Debold , Mattew Unger, Thomas Longyear 1488-Pos Board B465 DESR349P MUTATION RESULTS IN ULTRASTRUCTURAL DISRUPTIONS AND COMPROMISE OF SKELETAL MUSCLE BIOMECHANICS ALREADY AT PRE- CLINICAL STAGES IN YOUNG MICE BEFORE THE ONSET OF PROTEIN AG- GREGATION. S Diermeier, M. Haug, B. Reischl, A Buttgereit, S Schürmann, M Spörrer, W H. Goldmann , B Fabry, F Elhimine, R Stehle, G. Pfitzer, L. Winter, C Clemen, R Schröder, O Friedrich 1489-Pos Board B466 NEBULIN DEFICIENCY IN ADULT MUSCLE CAUSES SARCOMERIC DEFECTS AND MUSCLE-TYPE DEPENDENT CHANGES IN TROPHICITY - NOVEL IN- SIGHTS IN NEMALINE MYOPATHY. Frank W. Li 1490-Pos Board B467 EFFECTS OF ACE INHBITORS AND ANTI-MINERALOCORTICOIDS ON KINET- IC PARAMETERS OF STRIATED MUSCLE CONTRACTION AND RELAXATION AS WELL AS MEASUREMENTS OF FATIGABILITY IN MURINE MODELS OF DUCHENNE MUSCULAR DYSTROPHY. Eric Schultz 1491-Pos Board B468 THE SUPER-RELAXED STATE OF MYOSIN IS ALTERED BY ESTRADIOL IN SKELETAL MUSCLE OF AGED FEMALE MICE. Brett A. Colson, Karl J. Petersen, Thomas A. Bunch , Brittany C. Collins, David D. Thomas, Dawn A. Lowe 1492-Pos Board B469 DESTABILIZING THE SUPER RELAXED STATE OF SKELETAL MUSCLE MYOSIN TO TREAT OBESITY AND TYPE 2 DIABETES. Leonardo Nogara, Nariman Naber, Marcella Canton, Carlo Reggiani, Edward Pate, Roger Cooke Cell Mechanics, Mechanosensing, and Motility II (Boards B470 - B494) 1493-Pos Board B470 SPACE AND TIME IN LEUKOCYTE MIGRATION. Donald M. Guu , Thomas Quast, Luis Alvarez, U. Benjamin Kaupp, Waldemar Kolanus 1494-Pos Board B471 BAYESIAN PARAMETER ESTIMATION AND MODEL SELECTION FOR BIO- PHYSICAL MODELS OF LEUKOCYTE ROLLING. Mats L. Moskopp , Andreas Deussen, Triantafyllos Chavakis, Peter Dieterich 1495-Pos Board B472 FORWARD AND INVERSE APPROACHES TO CHARACTERIZING CELLULAR TRACTION FORCES. Ankur H. Kulkarni , Prasenjit Ghosh, Nagaraj Balasubramanian, Namrata Gundiah

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